机构

• 上海药物研究所 [22]
• 近代物理研究所 [8]
• 昆明植物研究所 [6]
• 上海生物化学与细胞生... [2]
• 合肥物质科学研究院 [2]
• 昆明动物研究所 [2]
• 更多

采集方式

• OAI收割 [44]

内容类型

• 期刊论文 [39]
• 会议论文 [4]
• 学位论文 [1]

发表日期

• 2023 [3]
• 2022 [3]
• 2021 [4]
• 2020 [4]
• 2019 [2]
• 2018 [3]
• 更多

学科主题

• Oncology [5]
• Cell Biolo... [2]
• Chemistry [1]
• Medicinal [1]
• Science & ... [1]
• 物理化学与绿色催化 [1]
• 更多

筛选

浏览/检索结果: 共44条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Discovery of 5-trifluoromethyl-2-aminopyrimidine derivatives as potent dual inhibitors of FLT3 and CHK1 期刊论文  OAI收割 RSC MEDICINAL CHEMISTRY, 2023, 页码: 14 作者:  Deng, Minjie;  Gao, Yue;  Wang, Peipei;  Du, Wenjing;  Xu, Gaoya   |  收藏  |  浏览/下载：7/0  |  提交时间：2024/02/19 Discovery of 2-Aminopyrimidine Derivatives as Potent Dual FLT3/CHK1 Inhibitors with Significantly Reduced hERG Inhibitory Activities 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 23 作者:  Li, Xuemei;  Wang, Peipei;  Wang, Chang;  Jin, Tingting;  Xu, Ran   |  收藏  |  浏览/下载：14/0  |  提交时间：2023/10/17 Design, Synthesis, and Biological Evaluation of 2-Aminothiazole Derivatives as Novel Checkpoint Kinase 1 (CHK1) Inhibitors 期刊论文  OAI收割 CHEMMEDCHEM, 2023, 页码: 19 作者:  Deng, Minjie;  Wang, Peipei;  Long, Xiubing;  Xu, Gaoya;  Wang, Chang   |  收藏  |  浏览/下载：13/0  |  提交时间：2023/04/10 2-aminothiazole  CHK1 inhibitors  antiproliferation  hematologic malignancies  biological activity   Dual inhibition of CHK1/FLT3 enhances cytotoxicity and overcomes adaptive and acquired resistance in FLT3-ITD acute myeloid leukemia 期刊论文  OAI收割 LEUKEMIA, 2022, 页码: 11 作者:  Jiang, Kailong;  Li, Xuemei;  Wang, Chang;  Hu, Xiaobei;  Wang, Peipei   |  收藏  |  浏览/下载：19/0  |  提交时间：2023/04/10 SOMCL-19-133, a novel, selective, and orally available inhibitor of NEDD8-activating enzyme (NAE) for cancer therapy 期刊论文  OAI收割 NEOPLASIA, 2022, 卷号: 32, 页码: 12 作者:  Zhou, Li-Na;  Xiong, Chaodong;  Cheng, Yong-Jun;  Song, Shan-Shan;  Bao, Xu-Bin   |  收藏  |  浏览/下载：14/0  |  提交时间：2023/04/10 SOMCL-19-133  NAE inhibitor  MLN4924  NEDD8  Oral administration   Repeated treatments of Capan-1 cells with PARP1 and Chk1 inhibitors promote drug resistance, migration and invasion 期刊论文  OAI收割 CANCER BIOLOGY & THERAPY, 2022, 页码: 14 作者:  Guo, Ne;  Li, Meng-Zhu;  Wang, Li-Min;  Chen, Hua-Dong;  Song, Shan-Shan   |  收藏  |  浏览/下载：27/0  |  提交时间：2022/06/15 Combination therapy  PARP1  resistance  CXCL3-ERK1/2 signaling  migration and invasion   Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 20, 页码: 15069-15090 作者:  Jin, Tingting;  Xu, Lei;  Wang, Peipei;  Hu, Xiaobei;  Zhang, Runyuan   |  收藏  |  浏览/下载：27/0  |  提交时间：2022/01/04 Comparable radiation sensitivity in p53 wild-type and p53 deficient tumor cells associated with different cell death modalities 期刊论文  OAI收割 CELL DEATH DISCOVERY, 2021, 卷号: 7, 期号: 1, 页码: 8 作者:  Li, Ping;  Liu, Xiongxiong;  Zhao, Ting;  Li, Feifei;  Wang, Qiqi   |  收藏  |  浏览/下载：40/0  |  提交时间：2021/12/09 Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9 作者:     |  收藏  |  浏览/下载：48/0  |  提交时间：2021/05/24 CHK1 inhibitors  PY34  drug sensitivity  c-Myc  hematologic malignancies   Design, Synthesis, and Biological Evaluation of Orally Bioavailable CHK1 Inhibitors Active against Acute Myeloid Leukemia 期刊论文  OAI收割 CHEMMEDCHEM, 2021, 页码: 12 作者:  Jin, Tingting;  Wang, Peipei;  Long, Xiubing;  Jiang, Kailong   |  收藏  |  浏览/下载：125/0  |  提交时间：2021/05/24 CHK1 inhibitor  diaminopyrimidine  DNA damage response  oral bioavailability