中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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长春应用化学研究所 [67]
上海药物研究所 [12]
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Discovery of novel covalent stabilizers for p53 Y220C using structure-based drug discovery methods
期刊论文
OAI收割
MOLECULAR DIVERSITY, 2025, 页码: 14
作者:
Wen, Yiming
;
Xu, Peijia
;
Chen, Yijie
;
Meng, Jingyi
;
Zheng, Mingyue
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2025/04/01
p53 Y220C
Covalent stabilizer
Virtual screening
Molecular dynamics
DNA binding
Structure-activity relationship
Cancer therapy
Intramolecular Folding of PolyT Oligonucleotides Induced by Cooperative Binding of Silver(I) Ions
期刊论文
OAI收割
MOLECULES, 2022, 卷号: 27, 期号: 22, 页码: 7842-1-14
作者:
Hao, Jinghua
;
Cao, Dong
;
Zhao, Qiang
;
Zhang, Dapeng
;
Wang, Hailin
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2023/02/06
cooperative binding
DNA
intramolecular folding
metal-mediated base pairs
silver ions
DNA demethylation affects imprinted gene expression in maize endosperm
期刊论文
OAI收割
GENOME BIOLOGY, 2022, 卷号: 23, 期号: 1
作者:
Xu, Qiang
;
Wu, Leiming
;
Luo, Zhixiang
;
Zhang, Mei
;
Lai, Jinsheng
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2024/03/07
DNA demethylation
Imprinting
Tissue-specific expression
Transcription factor binding
Maize
钌多吡啶络合物可逆调控活细胞DNA B-Z 构象转化机理研究
学位论文
OAI收割
北京: 中国科学院大学;中国科学院生态环境研究中心, 2021
作者:
唐 苗
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2022/06/22
Dna构象转变,钌多吡啶络合物,手性对映异构体,z-Dna抗体,z-Dna结合蛋白
Dna Conformational Conversion, Ru(Ii) Polypyridyl Cationic Complexes, Chiral Enantiomers, z-Dna Antibody, z-Dna Binding Proteins
An Integrative Framework for Combining Sequence and Epigenomic Data to Predict Transcription Factor Binding Sites Using Deep Learning
期刊论文
OAI收割
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 2021, 卷号: 18, 期号: 1, 页码: 355-364
作者:
Jing, Fang
;
Zhang, Shao-Wu
;
Cao, Zhen
;
Zhang, Shihua
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/04/26
Bioinformatics
machine learning
transcription factors binding sites
convolutional neural networks
DNA accessibility
histone modification
Adaptive innovation of green plants by horizontal gene transfer
期刊论文
OAI收割
BIOTECHNOLOGY ADVANCES, 2021, 卷号: 46, 页码: 107671
作者:
Chen,Rujia
;
Huangfu,Liexiang
;
Lu,Yue
;
Fang,Huimin
;
Xu,Yang
  |  
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2022/04/02
Plant evolution
adaptation
exaptation
plant-to-plant HGT
crop breeding and improvement
ICE-BINDING PROTEINS
LAND PLANTS
TRANSPOSABLE ELEMENTS
EVOLUTION
GENOME
ORIGIN
DNA
BIOSYNTHESIS
ALGA
RETROTRANSPOSONS
Mechanism of synergistic DNA damage induced by caffeic acid phenethyl ester (CAPE) and Cu(II): Competitive binding between CAPE and DNA with Cu(II)/Cu(I)
期刊论文
OAI收割
FREE RADICAL BIOLOGY AND MEDICINE, 2020, 卷号: 159, 页码: 107-118
作者:
Shao, Bo
;
Mao, Li
;
Shao, Jie
;
Huang, Chun-Hua
;
Qin, Li
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2021/09/14
Caffeic acid phenethyl ester
Cu(II)
DNA strand breakage
Hydroxyl radical
Competitive binding mechanism
Probe Efficient Feature Representation of Gapped K-mer Frequency Vectors from Sequences Using Deep Neural Networks
期刊论文
OAI收割
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 2020, 卷号: 17, 期号: 2, 页码: 657-667
作者:
Cao, Zhen
;
Zhang, Shihua
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/05/24
DNA
Bioinformatics
Kernel
Feature extraction
Support vector machines
Genomics
Task analysis
Bioinformatics
machine learning
gapped k-mer
deep neural network
transcription factor binding site prediction
Length feature of ssDNA adsorption onto graphene oxide with both large unoxidized and oxidized regions
期刊论文
OAI收割
NANOSCALE, 2020, 卷号: 12, 期号: 12, 页码: 6699-6707
作者:
Lei, XL
;
Ma, HS
;
Fang, HP
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2021/09/06
SINGLE-STRANDED-DNA
MOLECULAR-DYNAMICS
CARBON NANOTUBE
ATOMIC-STRUCTURE
MEMBRANES
BINDING
SURFACE
FUNCTIONALIZATION
NANOCOMPOSITES
SIMULATIONS
Unexpected sequence adsorption features of polynucleotide ssDNA on graphene oxide
期刊论文
OAI收割
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2020, 卷号: 22, 期号: 20, 页码: 11740-11746
作者:
Ma, HS
;
Xu, Z
;
Fang, HP
;
Lei, XL
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2021/09/06
MOLECULAR-DYNAMICS
CARBON NANOTUBE
NUCLEIC-ACIDS
STRANDED-DNA
CYTOSINE
BINDING
SURFACE
NANOCOMPOSITES
NANOMATERIALS
SIMULATIONS