机构

• 长春应用化学研究所 [7]
• 福建物质结构研究所 [2]
• 上海药物研究所 [2]
• 昆明植物研究所 [2]
• 金属研究所 [1]
• 水生生物研究所 [1]
• 更多

采集方式

• OAI收割 [16]

内容类型

• 期刊论文 [16]

发表日期

• 2025 [1]
• 2019 [1]
• 2017 [1]
• 2015 [1]
• 2011 [1]
• 2010 [2]
• 更多

学科主题

• Biochemist... [2]
• Chemistry,... [1]
• Chemistry,... [1]
• Environmen... [1]
• Pharmacolo... [1]
• Toxicology [1]
• 更多

筛选

浏览/检索结果: 共16条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Discovery of novel covalent stabilizers for p53 Y220C using structure-based drug discovery methods 期刊论文  OAI收割 MOLECULAR DIVERSITY, 2025, 页码: 14 作者:  Wen, Yiming;  Xu, Peijia;  Chen, Yijie;  Meng, Jingyi;  Zheng, Mingyue   |  收藏  |  浏览/下载：9/0  |  提交时间：2025/04/01 p53 Y220C  Covalent stabilizer  Virtual screening  Molecular dynamics  DNA binding  Structure-activity relationship  Cancer therapy   Increased PARP1-DNA binding due to autoPARylation inhibition of PARP1 on DNA rather than PARP1-DNA trapping is correlated with PARP1 inhibitor's cytotoxicity 期刊论文  OAI收割 INTERNATIONAL JOURNAL OF CANCER, 2019, 卷号: 145, 期号: 3, 页码: 714-727 作者:  Chen, Hua-Dong;  Chen, Chuan-Huizi;  Wang, Yu-Ting;  Guo, Ne;  Tian, Yu-Nan   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/03/21 PARP1 inhibitor  PARP1-DNA binding  PARP1-DNA trapping  poly(ADP-ribose) polymerase activity  cytotoxicity   Diterpenoids from Isodon species: an update 期刊论文  OAI收割 NATURAL PRODUCT REPORTS, 2017, 卷号: 34, 期号: 9, 页码: 1090-1140 作者:  Liu, Miao;  Wang, Wei-Guang;  Sun, Han-Dong;  Pu, Jian-Xin   |  收藏  |  浏览/下载：35/0  |  提交时间：2017/10/23 Ent-kaurane Diterpenoids  Japonica Var. Glaucocalyx  Nf-kappa-b  Hepatocellular-carcinoma Cells  C-h Functionalization  Dna-binding Activity  Serra Maxim. Hara  Maoecrystal-v  Abietane Diterpenoids  Chemical-constituents   Synthesis, crystal structures and catalytic activity of tetrakis(acetato)dirhodium(II) complexes with axial picoline ligands 期刊论文  OAI收割 INORGANICA CHIMICA ACTA, 2015, 卷号: 434, 页码: 113-120 作者:  Ye,Qing-Song;  Li,Xiao-Nian;  Jin,Yi;  Yu,Juan;  Chang,Qiao-Wen 收藏  |  浏览/下载：20/0  |  提交时间：2017/07/11 Rhodium  Acetate  Picoline  Catalytic activity  C-H center dot center dot center dot O hydrogen bond  Axial ligand  ACETATE  CARBOXYLATES  BINDING  ADDUCT  BONDS  UNITS  DNA   Noncovalent interactions between hydroxylated polycyclic aromatic hydrocarbon and DNA: Molecular docking and QSAR study 期刊论文  OAI收割 ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2011, 卷号: 32, 期号: 3, 页码: 373-381 作者:  Li, Fei;  Li, Xuehua;  Liu, Xiaoli;  Zhang, Linbao;  You, Liping   |  收藏  |  浏览/下载：39/0  |  提交时间：2012/03/06 Hydroxylated Polycyclic Aromatic Hydrocarbon (Ho-pah)  Dna  Quantitative Structure-activity Relationship (Qsar)  Binding Interaction  Docking   Sulforaphane Activates Heat Shock Response and Enhances Proteasome Activity through Up-regulation of Hsp27 期刊论文  OAI收割 JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 卷号: 285, 期号: 46, 页码: 35528-35536 作者:  Gan, Nanqin;  Wu, Yu-Chieh;  Brunet, Mathilde;  Garrido, Carmen;  Chung, Fung-Lung 收藏  |  浏览/下载：100/34  |  提交时间：2010/12/23 DNA-BINDING ACTIVITY  ALPHA-B-CRYSTALLIN  TRANSCRIPTION FACTOR  INCREASED EXPRESSION  26S PROTEASOME  CANCER CELLS  REDOX STATE  PROTEIN  DEGRADATION  INDUCTION   Applications of Ultrafiltration Mass Spectrometry in the Studies on Interaction Between Small Drug Molecule and Biological Target 期刊论文  OAI收割 progress in chemistry, 2010, 卷号: 22, 期号: 11, 页码: 2207-2214 Zhou H; Song FR; Liu ZQ; Liu SY 收藏  |  浏览/下载：21/0  |  提交时间：2012/04/25 SCREENING COMBINATORIAL LIBRARIES  PULSED ULTRAFILTRATION  NONCOVALENT COMPLEXES  ESTROGENIC ACTIVITY  ESI-MS  BINDING  AFFINITY  DNA  INHIBITORS  LIGAND   Synthesis, characterization, cytotoxic activity and DNA binding Ni(II) complex with the 6-hydroxy chromone-3-carbaldehyde thiosemicarbazone 期刊论文  OAI收割 Journal of Organometallic Chemistry, 2009, 卷号: 694, 期号: 25, 页码: 4069-4075 B. D. Wang, Z. Y. Yang, M. H. Lu, J. Hai, Q. Wang and Z. N. Chen 收藏  |  浏览/下载：61/0  |  提交时间：2012/11/06 6-hydroxy chromone-3-carbaldehyde thiosemicarbazone  Ni(II) complex  Crystal structure  DNA binding  Cytotoxic activity  benzoyl hydrazone  functionalized flavones  ln(iii) complexes  crystal-structure   Synthesis, characterization, cytotoxic activity and DNA binding Ni(II) complex with the 6-hydroxy chromone-3-carbaldehyde thiosemicarbazone 期刊论文  OAI收割 Journal of Organometallic Chemistry, 2009, 卷号: 694, 期号: 25, 页码: 4069-4075 B. D. Wang, Z. Y. Yang, M. H. Lu, J. Hai, Q. Wang and Z. N. Chen 收藏  |  浏览/下载：59/0  |  提交时间：2012/11/06 6-hydroxy chromone-3-carbaldehyde thiosemicarbazone  Ni(II) complex  Crystal structure  DNA binding  Cytotoxic activity  benzoyl hydrazone  functionalized flavones  ln(iii) complexes  crystal-structure   Influence of Polyelectrolyte on DNA-RecA Nucleoprotein Filaments: Poly-L-Lysine Used as a Model 期刊论文  OAI收割 chemphyschem, 2009, 卷号: 10, 期号: 9-10, 页码: 1624-1629 Guo CL; Li GP; Liu ZL; Sun LL; Sun YJ; Xu FG; Zhang Y; Yang T; Li ZA 收藏  |  浏览/下载：19/0  |  提交时间：2010/05/04 SINGLE-STRANDED-DNA  DEPENDENT ATPASE ACTIVITY  ESCHERICHIA-COLI  DUPLEX DNA  BINDING-PROTEIN  RECOMBINATION  INTERCALATORS  COMPLEXES  MECHANISM  EXCHANGE