机构

• 上海药物研究所 [17]
• 化学研究所 [2]
• 昆明植物研究所 [2]
• 合肥物质科学研究院 [1]
• 兰州化学物理研究所 [1]

采集方式

• OAI收割 [23]

内容类型

• 期刊论文 [23]

发表日期

• 2025 [1]
• 2023 [1]
• 2021 [1]
• 2019 [1]
• 2018 [2]
• 2017 [3]
• 更多

学科主题

• Biochemica... [1]
• Chemistry,... [1]

筛选

浏览/检索结果: 共23条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Novel conjugated 5-alkenyl rhodanine tethered 1,4-benzodioxane derivatives as dual-chitinases inhibitors to hinder the growth of Asian corn borer 期刊论文  OAI收割 MEDICINAL CHEMISTRY RESEARCH, 2025, 页码: 13 作者:  Chen, Jinxiu;  Shi, Dongmei;  Jiang, Zhiyang;  Zou, Renxuan;  Zhang, Jingyu   |  收藏  |  浏览/下载：4/0  |  提交时间：2025/04/01 O. furnacalis  Chitinase  5-alkenylthiazolidinone  1,4-benzodioxane  Dual-chitinases inhibitor   Discovery and biological evaluation of a new type of dual inhibitors of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase from ethnomedicinal plant Dactylicapnos scandens 期刊论文  OAI收割 PHYTOCHEMISTRY, 2023, 卷号: 214, 页码: 113794 作者:  Bao,Mei-Fen;  Yang,Xin-Ni;  Wu,Jing;  Liu,Jiang-Xin;  Cai,Xiang-Hai   |  收藏  |  浏览/下载：25/0  |  提交时间：2024/07/25 Dactylicapnos scandens (D. don) hutch.  Isoquinoline alkaloids  Aporphine-type alkaloids  Dactycapnine a  IDO1/TDO dual inhibitor  APORPHINE ALKALOIDS  N-OXIDE  INFLAMMATION  PATHWAY  THALIPORPHINE  COMPLEXES  CANCER  ROOTS   Dual self-healing composite coating on magnesium alloys for corrosion protection 期刊论文  OAI收割 Chemical Engineering Journal, 2021, 期号: 424, 页码: 1-12 作者:  Liu, Siqin;  Li, Zhaoxia;  Yu, Qiangliang;  Qi, Yuming;  Peng, Zhenjun   |  收藏  |  浏览/下载：74/0  |  提交时间：2021/11/23 Dual self-healing  Micro-arc oxidation  Corrosion inhibitor  Polyurethane  Disulfide bond   Identification of new dual FABP4/5 inhibitors based on a naphthalene-1-sulfonamide FABP4 inhibitor 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 19, 页码: 16 作者:  He, Yulong;  Dou, Huixia;  Gao, Dingding;  Wang, Ting;  Zhang, Mingming   |  收藏  |  浏览/下载：41/0  |  提交时间：2020/07/01 Dual FABP4/5 inhibitor  Structure-based design  Lipolysis inhibition  Anti-inflammatory effects   Design, synthesis and pharmacological evaluation of ALK and Hsp90 dual inhibitors bearing resorcinol and 2,4-diaminopyrimidine motifs 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 152, 页码: 76-86 作者:  Geng, Kaijun;  Liu, Hongchun;  Song, Zilan;  Zhang, Chi;  Zhang, Minmin   |  收藏  |  浏览/下载：190/0  |  提交时间：2019/01/08 Heat shock protein 90 (Hsp90)  Tyrosine kinase ALK  Dual inhibitor  Drug resistance  Antiproliferative activity   Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease 期刊论文  OAI收割 ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 2, 页码: 328-345 作者:  Mao, Fei;  Wang, Huan;  Ni, Wei;  Zheng, Xinyu;  Wang, Manjiong   |  收藏  |  浏览/下载：62/0  |  提交时间：2019/01/08 Alzheimer's disease  drug repositioning  dual-target inhibitor  AChE inhibition  PDE5 inhibition   Discovery and development of pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer 期刊论文  OAI收割 EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 卷号: 110, 页码: 51-61 作者:  Li, Xin;  Yang, Changyong;  Wan, Hong;  Zhang, Ge;  Feng, Jun   |  收藏  |  浏览/下载：148/0  |  提交时间：2019/01/08 Pyrotinib  HER2-postive breast cancer  Irreversible EGFR/HER2 dual tyrosine kinase  inhibitor  Preclinical  Clinical  Safety  Drug metabolism   Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 期号: 无, 页码: 674-697 作者:  Chen, Yongfei;  Wu, Jiaxin;  Wang, Aoli;  Qi, Ziping;  Jiang, Taoshan   |  收藏  |  浏览/下载：878/0  |  提交时间：2018/08/17 Egfr  Alk  Dual Kinase Inhibitor  Non-small Cell Lung Cancer   Design, Synthesis, and Biological Evaluation of the First c-Met/HDAC Inhibitors Based on Pyridazinone Derivatives 期刊论文  OAI收割 ACS MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 8, 期号: 8, 页码: 830-834 作者:  Lu, Dong;  Yan, Juan;  Wang, Lang;  Liu, Hongchun;  Zeng, Limin   |  收藏  |  浏览/下载：58/0  |  提交时间：2019/01/08 Dual c-Met/HDAC inhibitor  hybrid  designed multiple ligand (DML)   2,4-Diarylamino-pyrimidines as kinase inhibitors co-targeting IGF1R and EGFR(L858R/T790M) 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 卷号: 25, 期号: 19, 页码: 4277-4281 作者:  Chan, Shingpan;  Han, Kun;  Qu, Rong;  Tong, Linjiang;  Li, Yingjun   |  收藏  |  浏览/下载：54/0  |  提交时间：2019/01/08 EGFR  IGF1R  NSCLC  Dual inhibitor