中国科学院机构知识库网格系统: 检索

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	Structure-based design of a novel inhibitor of the ZIKA virus NS2B/ NS3 protease 期刊论文 OAI收割 BIOORGANIC CHEMISTRY, 2022, 卷号: 128, 页码: 7 作者: Xiong, Yanchao; Cheng, Fei; Zhang, Junyi; Su, Haixia; Hu, Hangchen \| 收藏 \| 浏览/下载：41/0 \| 提交时间：2022/11/11 Zika virus Fragment -based hit screening Protein -inhibitor interactions NS2B NS3 protease Crystal structure
	Recent progress in fragment-based drug discovery facilitated by NMR spectroscopy 期刊论文 OAI收割 Magnetic Resonance Letters, 2022, 卷号: 2, 期号: 2, 页码: 107-118 作者: Wang, Lei; Gao, Jia; Ma, Rongsheng; Liu, Yaqian; Liu, Mingqing \| 收藏 \| 浏览/下载：23/0 \| 提交时间：2024/03/14 Fragment-based lead/drug discovery NMR spectroscopy Protein-ligand interaction Complex structure Hit-to-lead evolution
	Lipoprotein-associated phospholipase A2: The story continues 期刊论文 OAI收割 MEDICINAL RESEARCH REVIEWS, 2020, 卷号: 40, 期号: 1, 页码: 79-134 作者: Huang, Fubao; Wang, Kai; Shen, Jianhua \| 收藏 \| 浏览/下载：19/0 \| 提交时间：2020/07/01 fragment-based lead discovery inflammation inhibitors lipoprotein-associated phospholipase A2 vascular diseases
	Fragment-based drug discovery of triazole inhibitors to block PDE delta-RAS protein-protein interaction 期刊论文 OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 163, 页码: 597-609 作者: Chen, Danqi; Chen, Yuehong; Lian, Fulin; Chen, Liu; Li, Yanlian \| 收藏 \| 浏览/下载：28/0 \| 提交时间：2020/07/01 PDE delta-RAS Fragment-based Inhibitor Protein-protein interaction
	Nmr-based platform for fragment-based lead discovery used in screening brd4-targeted compounds 期刊论文 iSwitch采集 Acta pharmacologica sinica, 2016, 卷号: 37, 期号: 7, 页码: 984-993 作者: Yu, Jun-lan; Chen, Tian-tian; Zhou, Chen; Lian, Fu-lin; Tang, Xu-long 收藏 \| 浏览/下载：32/0 \| 提交时间：2019/05/09 Fragment-based lead discovery Nmr Bromodomain Brd4 inhibitors
	NMR-based platform for fragment-based lead discovery used in screening BRD4-targeted compounds 期刊论文 OAI收割 ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 7, 页码: 984-993 作者: Yu, Jun-lan; Chen, Tian-tian; Zhou, Chen; Lian, Fu-lin; Tang, Xu-long \| 收藏 \| 浏览/下载：29/0 \| 提交时间：2019/01/08 fragment-based lead discovery NMR bromodomain BRD4 inhibitors
	Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors 期刊论文 OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 卷号: 87, 页码: 765-781 作者: Chen, Danqi; Shen, Aijun; Li, Jian; Shi, Feng; Chen, Wuyan \| 收藏 \| 浏览/下载：36/0 \| 提交时间：2019/01/08 HSP90 Fragment-based drug discovery Crystallography
	Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization 期刊论文 OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 卷号: 24, 期号: 11, 页码: 2525-2529 作者: Ren, Jing; Li, Jian; Wang, Yueqin; Chen, Wuyan; Shen, Aijun \| 收藏 \| 浏览/下载：22/0 \| 提交时间：2019/01/08 Heat shock protein HSP90 Fragment-based drug discovery Anticancer
	Novel soluble myeloid cell leukemia sequence 1 (Mcl-1) inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g) developed using a fragment-based approach 期刊论文 OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 59, 期号: 59, 页码: 141-149 作者: Zhang, Zhichao; Song, Ting; Li, Xiangqian; Wu, Zhiyong; Feng, Yingang 收藏 \| 浏览/下载：32/0 \| 提交时间：2014/03/24 Mcl-1 Small molecule inhibitor Fragment-based approach Anticancer