中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [8]
昆明动物研究所 [4]
大连化学物理研究所 [1]
采集方式
OAI收割 [13]
内容类型
期刊论文 [13]
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2017 [2]
2014 [1]
2013 [1]
2009 [2]
2008 [5]
2004 [2]
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Discovery of novel 3-hydroxypicolinamides as selective inhibitors of HIV-1 integrase-LEDGF/p75 interaction
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 125, 页码: 1051-1063
作者:
Zhang, Feng-Hua
;
Debnath, Bikash
;
Xu, Zhong-Liang
;
Yang, Liu-Meng
;
Song, Li-Rui
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
HIV-1 integrase
Allosteric inhibitor
LEDGF/p75
Dimerization
3-Hydroxypicolinamide
Discovery of novel 3-hydroxypicolinamides as selective inhibitors of HIV-1 integrase-LEDGF/p75 interaction
期刊论文
OAI收割
European Journal of Medicinal Chemistry, 2017, 卷号: 125, 期号: X, 页码: 1051-1063
作者:
Zhang FH
;
Debnath B
;
Zheng YT
;
Neamati N[*]
;
Long YQ[*]
收藏
  |  
浏览/下载:83/0
  |  
提交时间:2016/11/07
3-Hydroxypicolinamide
Allosteric inhibitor
Dimerization
HIV-1 integrase
LEDGF/p75
2芳基3羰基喹诺酮新型hcvns5b多聚酶抑制剂的设计合成和活性评估
期刊论文
OAI收割
化学学报, 2014, 卷号: 72, 期号: 8, 页码: 906
作者:
王沈丰
;
林建平
;
何佩岚
;
左建平
;
龙亚秋
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/07/01
HEPATITIS-C VIRUS
HIV-1 INTEGRASE INHIBITORS
INFECTION
NUCLEOTIDE
SCAFFOLD
SOFOSBUVIR
DISCOVERY
LEDGF/P75
ACIDS
HCV NS5B polymerase
2-substituted quinolone-3-carboxylic acid
non-nucleoside inhibitor
direct acting antiviral
allosteric site
Synthesis and biological evaluation of 5-fluoroquinolone-3-carboxylic acids as potential HIV-1 integrase inhibitors
期刊论文
OAI收割
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2013, 卷号: 28, 期号: 4, 页码: 671-676
作者:
He QQ
;
Zhang X
;
Yang LM
;
Zheng YT
;
Chen F[*]
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2013/08/27
HIV-1 integrase inhibitor
5-fluoroquinolone-3-carboxylic acids
anti-HIV activity
metal chelating
structure-activity relationship
Advances in HIV-1 Integrase Inhibitors Directed toward Different Steps of Integration
期刊论文
OAI收割
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2009, 卷号: 29, 期号: 4, 页码: 536-547
作者:
Zeng Lifan
;
Long Yaqiu
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2019/01/08
HIV-1 integrase
inhibitor
anti-HIV drug
raltegravir (MK-0518)
GS-9137
advancesinhiv1integraseinhibitorsdirectedtowarddifferentstepsofintegration
期刊论文
OAI收割
chinesejournaloforganicchemistry, 2009, 卷号: 29, 期号: 4, 页码: 536
作者:
Ceng LF(曾立凡)
;
Long YQ(龙亚秋)
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/07/01
IMMUNODEFICIENCY-VIRUS TYPE-1
ACTIVE ANTIRETROVIRAL THERAPY
HIGHLY EFFICIENT PREPARATION
STYRYLQUINOLINE DERIVATIVES
REVERSE-TRANSCRIPTASE
PEPTIDE INHIBITORS
VIRAL REPLICATION
DESIGN
MECHANISM
BINDING
HIV-1 integrase
inhibitor
anti-HIV drug
raltegravir (MK-0518)
GS-9137
Symmetrical 1-pyrrolidineacetamide showing anti-HIV activity through a new binding site on HIV-1 integrase
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2008, 卷号: 29, 期号: 10, 页码: 1261-1267
作者:
Du, Li
;
Zhao, Ya-xue
;
Yang, Liu-meng
;
Zheng, Yong-tang
;
Tang, Yun
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
HIV-1 integrase inhibitor
surface plasma resonance
molecular docking
site-directed mutagenesis
Investigation of formation of dimeric G-quadruplex of HIV-1 integrase inhibitor by nuclear magnetic resonance
期刊论文
OAI收割
chinese chemical letters, 2008, 卷号: 19, 期号: 9, 页码: 1108-1110
作者:
Li, Hui Hui
;
Yuan, Gu
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2015/11/12
G-quadruplex
HIV-1 integrase inhibitor
Nuclear magnetic resonance
Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 卷号: 18, 期号: 16, 页码: 4521-4524
作者:
Zeng, Li-Fan
;
Zhang, Hu-Shan
;
Wang, Yun-Hua
;
Sanchez, Tino
;
Zheng, Yong-Tang
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
HIV-1 integrase inhibitor
bioisostere
heteroaromatic carboxylic acid
isoxazole
isothiazole
1H-pyrazole
bioavailability
antiviral effect
Symmetrical 1-pyrrolidineacetamide showing anti-HIV activity through a new binding site on HIV-1 integrase
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2008, 卷号: 29, 期号: 10, 页码: 1261-1267
作者:
Du L
;
Zhao YX
;
Yang LM
;
Zheng YT
;
Tang Y[*]
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2010/08/24
HIV-1 integrase inhibitor
surface plasma resonance
molecular docking
site-directed mutagenesis