中国科学院机构知识库网格系统: 检索

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	Discovery of hematopoietic progenitor kinase 1 inhibitors using machine learning-based screening and free energy perturbation 期刊论文 OAI收割 JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2024, 页码: 13 作者: Feng, Dazhi; Liu, Bo; Chen, Zhiwei; Xu, Jinyi; Geng, Meiyu \| 收藏 \| 浏览/下载：48/0 \| 提交时间：2024/02/27 HPK1 inhibitor machine learning virtual screening free energy perturbation structural modification
	Design and synthesis of 1H-pyrazolo[3,4-d]pyrimidine derivatives as hematopoietic progenitor kinase 1 (HPK1) inhibitors 期刊论文 OAI收割 BIOORGANIC CHEMISTRY, 2023, 卷号: 140, 页码: 18 作者: Zhang, Junjie; Li, Yan; Tang, Haotian; Zhou, Qianqian; Tong, Linjiang \| 收藏 \| 浏览/下载：22/0 \| 提交时间：2023/12/08 Cancer immunotherapy HPK1 Structure -based design HPK1 inhibitor
	Discovery of 7H-Pyrrolo[2,3-d]pyrimidine Derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors 期刊论文 OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 254, 页码: 15 作者: Wu, Feifei; Li, Huiyu; An, Qi; Sun, Yaoliang; Yu, Jinghua \| 收藏 \| 浏览/下载：22/0 \| 提交时间：2023/10/17 Hematopoietic progenitor kinase 1 (HPK1) Cancer immunotherapy Inhibitor T cell
	Development of a series of quinazoline-2,5-diamine derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors 期刊论文 OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 248, 页码: 20 作者: Shi, Huanyu; Tang, Haotian; Li, Yan; Chen, Danqi; Liu, Tongchao \| 收藏 \| 浏览/下载：31/0 \| 提交时间：2023/04/10 Cancer immunotherapy SAR study HPK1 inhibitors Quinazoline-2 5-diamine IL-2 production
	Tyrosine phosphorylation of HPK1 by activated Src promotes ischemic brain injury in rat hippocampal CA1 region 期刊论文 OAI收割 FEBS LETTERS, 2008, 卷号: 582, 期号: 13, 页码: 1894-1900 作者: Li, Ting; Yu, Xiu-Ju; Zhang, Guang-Yi \| 收藏 \| 浏览/下载：31/0 \| 提交时间：2019/01/08 HPK1 cerebral ischemia Src N-methyl-D-aspartate receptor (NMDAR) neuroprotection c-jun NH2-terminal kinase (JNK)