机构

• 上海药物研究所 [8]

采集方式

• OAI收割 [8]

内容类型

• 期刊论文 [8]

发表日期

• 2024 [1]
• 2023 [4]
• 2008 [3]

学科主题

• Biochemist... [1]
• Biophysics [1]
• Cell Biolo... [1]

筛选

浏览/检索结果: 共8条，第1-8条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Discovery of hematopoietic progenitor kinase 1 inhibitors using machine learning-based screening and free energy perturbation 期刊论文  OAI收割 JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2024, 页码: 13 作者:  Feng, Dazhi;  Liu, Bo;  Chen, Zhiwei;  Xu, Jinyi;  Geng, Meiyu   |  收藏  |  浏览/下载：24/0  |  提交时间：2024/02/27 HPK1 inhibitor  machine learning  virtual screening  free energy perturbation  structural modification   Design, Synthesis, and Pharmacological Evaluation of Isoindoline Analogues as New HPK1 Inhibitors 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 23, 页码: 16201-16221 作者:  Xie, Chenghu;  Liu, Bo;  Song, Zilan;  Yang, Ye;  Dai, Mengdi   |  收藏  |  浏览/下载：16/0  |  提交时间：2024/02/27 Design and synthesis of 1H-pyrazolo[3,4-d]pyrimidine derivatives as hematopoietic progenitor kinase 1 (HPK1) inhibitors 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2023, 卷号: 140, 页码: 18 作者:  Zhang, Junjie;  Li, Yan;  Tang, Haotian;  Zhou, Qianqian;  Tong, Linjiang   |  收藏  |  浏览/下载：8/0  |  提交时间：2023/12/08 Cancer immunotherapy  HPK1  Structure -based design  HPK1 inhibitor   Discovery of 7H-Pyrrolo[2,3-d]pyrimidine Derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 254, 页码: 15 作者:  Wu, Feifei;  Li, Huiyu;  An, Qi;  Sun, Yaoliang;  Yu, Jinghua   |  收藏  |  浏览/下载：9/0  |  提交时间：2023/10/17 Hematopoietic progenitor kinase 1 (HPK1)  Cancer immunotherapy  Inhibitor  T cell   Development of a series of quinazoline-2,5-diamine derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 248, 页码: 20 作者:  Shi, Huanyu;  Tang, Haotian;  Li, Yan;  Chen, Danqi;  Liu, Tongchao   |  收藏  |  浏览/下载：19/0  |  提交时间：2023/04/10 Cancer immunotherapy  SAR study  HPK1 inhibitors  Quinazoline-2  5-diamine  IL-2 production   Tyrosine phosphorylation of HPK1 by activated Src promotes ischemic brain injury in rat hippocampal CA1 region 期刊论文  OAI收割 FEBS LETTERS, 2008, 卷号: 582, 期号: 13, 页码: 1894-1900 作者:  Li, Ting;  Yu, Xiu-Ju;  Zhang, Guang-Yi   |  收藏  |  浏览/下载：21/0  |  提交时间：2019/01/08 HPK1  cerebral ischemia  Src  N-methyl-D-aspartate receptor (NMDAR)  neuroprotection  c-jun NH2-terminal kinase (JNK)   Neuroprotection against ischemic brain injury by knockdown of hematopietic progenitor kinase 1 expression 期刊论文  OAI收割 NEUROREPORT, 2008, 卷号: 19, 期号: 6, 页码: 647-651 作者:  Li, Ting;  Han, Dong;  Chen, Juan;  Yu, Xiuju;  Zhang, Guang-Yi   |  收藏  |  浏览/下载：16/0  |  提交时间：2019/01/08 antisense oligodeoxynucleotides  cerebral ischemia  c-Jun NH2-terminal kinase  hematopietic progenitor kinase 1