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浏览/检索结果: 共1417条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序作者升序作者降序 Discovery of novel Ebola entry inhibitors with 1,2,3,4-tetrahydroisoquinoline-3-carboxamide based on (3S,4aS,8aS)-2-(3-amino-2-hydroxypropyl) decahydroisoquinoline-3-carboxamide scaffold 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 123, 页码: 4 作者:  Lin, Junzhen;  Xiao, Fuling;  Han, Sheng;  Hu, Youhong;  Zuo, Jianping   |  收藏  |  浏览/下载：0/0  |  提交时间：2025/06/23 Ebola virus entry inhibitor  Tetrahydroisoquinoline   Covalent sortase A inhibitor, α, β-unsaturated aldehydes, prevents Staphylococcus aureus infection 期刊论文  OAI收割 MICROBIAL PATHOGENESIS, 2025, 卷号: 204, 页码: 12 作者:  Wang, Jianchao;  He, Yuan;  Chu, Chenliang;  Wu, Ziqi;  Zhang, Ting   |  收藏  |  浏览/下载：0/0  |  提交时间：2025/06/23 Sortase A  Covalent inhibitor  alpha  beta-unsaturated aldehydes  Anti-virulence therapy  Staphylococcus aureus   Research progress on critical viral protease inhibitors for coronaviruses and enteroviruses 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 122, 页码: 19 作者:  Hu, Shulei;  Zhong, Qiuyu;  Xie, Xiong;  Zhang, Shurui;  Wang, Jinlin   |  收藏  |  浏览/下载：0/0  |  提交时间：2025/05/27 Innate immunity response  SARS-CoV-2 3CLpro  PLpro  EV71 3Cpro  2Apro  Viral protease inhibitor   Design, synthesis and bio-evaluation of 2,5-disubstituted thiazole derivatives for potential treatment of acute myeloid leukemia through targeting CDK9 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2025, 卷号: 160, 页码: 16 作者:  Chen, Sumeng;  Huang, Jindi;  Zhang, Shipeng;  Zheng, Xinni;  Chen, Hongming   |  收藏  |  浏览/下载：0/0  |  提交时间：2025/06/23 CDK9  Inhibitor  Acute myeloid leukemia  Binding mode  Cellular mechanism   Discovery of multi-chitinase inhibitors cinnamyl thiazolidinone compounds as candidates for insect growth regulators via ligand-based optimization strategies 期刊论文  OAI收割 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2025, 卷号: 306, 页码: 14 作者:  Jiang, Zhiyang;  Shi, Dongmei;  Fu, Haoyu;  Li, Yan;  Zou, Renxuan   |  收藏  |  浏览/下载：1/0  |  提交时间：2025/05/27 Multi-chitinase inhibitor  Cinnamaldehyde compounds  Thiazolidinone compounds  Ligand-based optimization  Insect growth regulators (IGRs)   The combination of BET and METTL3 inhibitors elicits synergistic antitumor effects in ovarian cancer cells via reducing SP1 and BCL-2 expression 期刊论文  OAI收割 LIFE SCIENCES, 2025, 卷号: 368, 页码: 14 作者:  Ou, Ying-Jie;  Liu, Ben-Jin;  Xuan, Yi-Fei;  Bao, Xu-Bin;  Huan, Xia-Juan   |  收藏  |  浏览/下载：1/0  |  提交时间：2025/04/24 BET inhibitor  METTL3 inhibitor  Combination therapy  SP1  BCL-2   Pharmacokinetics and Safety of TPN171 (a PDE5 Inhibitor) in Patients With Mild or Moderate Hepatic Impairment Versus Participants With Normal Hepatic Function: A Phase I Study 期刊论文  OAI收割 CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2025, 页码: 7 作者:  Zhou, Jing;  Zhang, Hong;  Ding, Yanhua;  Wang, Zhen;  Wang, Yu   |  收藏  |  浏览/下载：0/0  |  提交时间：2025/06/23 hepatic impairment  pharmacokinetics  phosphodiesterase-5 inhibitor  TPN171   A Phase I Study to Evaluate the Pharmacokinetics and Safety of TPN171 (a PDE5 Inhibitor) in Adults with Renal Impairment 期刊论文  OAI收割 CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2025, 页码: 8 作者:  Fu, Ping;  Song, Yi;  Hu, Chao;  Yong, Xiaolan;  Yu, Yang   |  收藏  |  浏览/下载：1/0  |  提交时间：2025/06/23 pharmacokinetics  phosphodiesterase 5 inhibitor  renal impairment  safety  TPN171   Apigenin alleviates inflammation as a natural IRAK4 inhibitor 期刊论文  OAI收割 PHYTOMEDICINE, 2025, 卷号: 139, 页码: 12 作者:  Gongpan, Pianchou;  Xu, Tingting;  Zhang, Yufei;  Ji, Kailong;  Kong, Lingmei   |  收藏  |  浏览/下载：2/0  |  提交时间：2025/04/24 Apigenin  IRAK4 inhibitor  Anti-inflammation  NF-kappa B  MAPK pathways  Ulcerative colitis   Structure-Based Discovery of a Series of Novel MAT2a Inhibitors 期刊论文  OAI收割 ACS MEDICINAL CHEMISTRY LETTERS, 2025, 页码: 5 作者:  Zhou, Yushan;  Wang, Li;  Ren, Ruyue;  Zhang, Junjie;  Huan, Xiajuan   |  收藏  |  浏览/下载：0/0  |  提交时间：2025/05/27 MAT2a  MTAP  Synthetic lethality  Allosteric inhibitor  Structure-activity relationship