中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页
机构
成果
学者
登录
注册
登陆
×
验证码:
换一张
忘记密码?
记住我
×
校外用户登录
CAS IR Grid
机构
上海药物研究所 [10]
采集方式
OAI收割 [10]
内容类型
期刊论文 [10]
发表日期
2022 [1]
2019 [1]
2018 [1]
2016 [2]
2013 [4]
2011 [1]
更多
学科主题
筛选
浏览/检索结果:
共10条,第1-10条
帮助
条数/页:
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
排序方式:
请选择
题名升序
题名降序
提交时间升序
提交时间降序
作者升序
作者降序
发表日期升序
发表日期降序
Diversity-oriented synthesis of marine polybrominated diphenyl ethers as potential KCNQ potassium channel activators
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2022, 卷号: 126, 页码: 105909
作者:
Liu, Lai-Xin
;
Gu, Ru-Rong
;
Jin, Yang
;
Chen, Xue-Qin
;
Li, Xu-Wen
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2024/03/21
Marine Natural product
Polybrominated diphenyl ethers
KCNQ potassium channel
Discovery of Novel Retigabine Derivatives as Potent KCNQ4 and KCNQ5 Channel Agonists with Improved Specificity
期刊论文
OAI收割
ACS MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 10, 期号: 1, 页码: 27-33
作者:
Wang, Lei
;
Qiao, Guan-Hua
;
Hu, Hai-Ning
;
Gao, Zhao-Bing
;
Nan, Fa-Jun
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/01
KCNQ channel
retigabine
subtype selectivity
agonist
A Statistical Thermodynamic Model for Ligands Interacting With Ion Channels: Theoretical Model and Experimental Validation of the KCNQ2 Channel
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:
Bai, Fang
;
Pi, Xiaoping
;
Li, Ping
;
Zhou, Pingzheng
;
Yang, Huaiyu
  |  
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2019/01/08
KCNQ2 potassium channel
hill equation
thermodynamic model
patch clamp electrophysiology
activators
Novel KCNQ2 channel activators discovered using fluorescence-based and automated patch-clamp-based high-throughput screening techniques
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 1, 页码: 105-110
作者:
Yue, Jin-feng
;
Qiao, Guan-hua
;
Liu, Ni
;
Chen, Xue-qin
;
Nan, Fa-jun
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
KCNQ2
channel activator
high-throughput screening
thallium flux assay
automated patch-clamp
ZG1732
ZG2083
Novel KCNQ2 channel activators discovered using fluorescence-based and automated patch-clampbased high-throughput screening techniques
期刊论文
OAI收割
Acta Pharmacologica Sinica, 2016, 卷号: 37, 期号: 1, 页码: 105
作者:
Yue Jinfeng
;
Qiao Guanhua
;
Liu Ni
;
Chen Xueqin
;
Nan Fajun
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/07/01
POTASSIUM CHANNEL
KV7 CHANNELS
EPILEPSY
IDENTIFICATION
GENE
KCNQ2
channel activator
high-throughput screening
thallium flux assay
automated patch-clamp
ZG1732
ZG2083
Discovery of a retigabine derivative that inhibits KCNQ2 potassium channels
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2013, 卷号: 34, 期号: 10, 页码: 1359-1366
作者:
Hu, Hai-ning
;
Zhou, Ping-zheng
;
Chen, Fei
;
Li, Min
;
Nan, Fa-jun
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
KCNQ2 channel
retigabine
HN38
XE991
structure modification
CHO cell
whole-cell recording
The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands
期刊论文
OAI收割
CELL RESEARCH, 2013, 卷号: 23, 期号: 9, 页码: 1106-1118
作者:
Li, Ping
;
Chen, Zhuxi
;
Xu, Haiyan
;
Sun, Haifeng
;
Li, Hao
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
voltage-gated potassium channel
gating charge pathway
KCNQ2 activator
binding site
anti-epilepsy drug
The ethylene bis-dithiocarbamate fungicide Mancozeb activates voltage-gated KCNQ2 potassium channel
期刊论文
OAI收割
TOXICOLOGY LETTERS, 2013, 卷号: 219, 期号: 3, 页码: 211-217
作者:
Li, Ping
;
Zhu, Jin
;
Kong, Qingya
;
Jiang, Baifeng
;
Wan, Xia
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
Mancozeb
Fungicide
KCNQ2 channel
Ethylene bis-dithiocarbamates
KCNQ1 potassium channel and its small molecular modulator
期刊论文
OAI收割
Chinese Journal of New Drugs and Clinical Remedies, 2013, 卷号: 32, 期号: 11, 页码: 843-849
作者:
Lan Xi
;
Li Min
;
Gao Zhaobing
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
KCNE
KCNQ1 potassium channel
KCNE
arrhythmia
action potentials
small molecular activator
high throughput screening
Identification of novel KCNQ4 openers by a high-throughput fluorescence-based thallium flux assay
期刊论文
OAI收割
ANALYTICAL BIOCHEMISTRY, 2011, 卷号: 418, 期号: 1, 页码: 66-72
作者:
Li, Qunyi
;
Rottlander, Mario
;
Xu, Mingkai
;
Christoffersen, Claus Tornby
;
Frederiksen, Kristen
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/01/08
KCNQ
Kv7
Patch clamp
Stable cell line
Thallium flux
(86)Rubidium flux
Potassium channel opener
High-throughput screening