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Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
化学研究所 [7]
过程工程研究所 [7]
上海药物研究所 [5]
大连化学物理研究所 [5]
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期刊论文 [52]
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2024 [1]
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2019 [3]
2018 [6]
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Rational Design and Synthesis of Novel Benzimidazole Derivatives as Potential
β
-Glucosidase Inhibitors
期刊论文
OAI收割
LETTERS IN DRUG DESIGN & DISCOVERY, 2024, 卷号: 21, 期号: 13, 页码: 2674-2683
作者:
Liu, Xu
;
Sun, Ge
;
Li, Fengxing
;
Feng, Xia
;
Jia, Tongguan
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/11/05
beta-glucosidase inhibitors
benzimidazole
linker
solvent-exposed region
o-trihydroxyphenol
iminosugar
Comparative Analysis of Chemical Cross-Linking Mass Spectrometry Data Indicates That Protein STY Residues Rarely React with N-Hydroxysuccinimide Ester Cross-Linkers
期刊论文
OAI收割
JOURNAL OF PROTEOME RESEARCH, 2023, 卷号: 22, 期号: 8, 页码: 2593-2607
作者:
Cao, Yong
;
Liu, Xin-Tong
;
Mao, Peng-Zhi
;
Chen, Zhen-Lin
;
Tarn, Ching
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/12/04
CXMS
XL-MS
NHS ester cross-linker
pLink
xiSearch
MeroX
Engineering Enzyme-Cleavable Oligonucleotides by Automated Solid-Phase Incorporation of Cathepsin B Sensitive Dipeptide Linkers
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022
作者:
Jin, Cheng
;
Ei-Sagheer, Afaf H.
;
Li, Siqi
;
Vallis, Katherine A.
;
Tan, Weihong
  |  
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2022/03/21
Cathepsin B
DNA Breakage
Dipeptide Linker
Oligonucleotide-Drug Conjugates
Solid-Phase Synthesis
Divalent tranylcypromine derivative as lysine-specific demethylase 1 inhibitor
期刊论文
OAI收割
MEDICINAL CHEMISTRY RESEARCH, 2021, 页码: 8
作者:
Sun, Yin
;
Li, Na
;
Su, Mingbo
;
Wang, Xiaowen
;
Zhao, Dongmei
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2021/05/24
Divalent tranylcypromine
LSD1 inhibitor
MV4-11 antiproliferative activity
CD86 mRNA expression
Linker
Selectivity
Effects of conserved Arg20, Glu74 and Asp77 on the structure and function of a tau class glutathione S-transferase in rice
期刊论文
OAI收割
PLANT MOLECULAR BIOLOGY, 2021, 卷号: 105, 期号: 4-5, 页码: 451-462
作者:
Yang, Xue
;
Wu, Zhihai
;
Gao, Jie
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2023/02/24
Glutathione S-transferases
Domain interaction
Linker region
Site-directed mutagenesis
Structural changes
Activity changes
Conjugation of staphylokinase with the arabinogalactan-PEG conjugate: Study on the immunogenicity, in vitro bioactivity and pharmacokinetics
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2019, 卷号: 131, 页码: 896-904
作者:
Qi, Fangbing
;
Qi, Jinming
;
Hu, Chunyang
;
Shen, Lijuan
;
Yu, Weili
  |  
收藏
  |  
浏览/下载:85/0
  |  
提交时间:2019/06/14
Staphylokinase
Arabinogalactan
Immunogenicity
Pharmacokinetic
PEG linker
in vitro activity
Palladium-Catalyzed Propargylic [n+2] Cycloaddition: An Efficient Strategy for Construction of Benzo-Fused Medium-Sized Heterocycles
期刊论文
OAI收割
ADVANCED SYNTHESIS & CATALYSIS, 2019, 卷号: 361, 期号: 4, 页码: 836-841
作者:
Liu, Zhen-Ting
;
Hu, Xiang-Ping
  |  
收藏
  |  
浏览/下载:66/0
  |  
提交时间:2019/06/20
A regioselective palladium-catalyzed formal [n+2] cycloaddition of propargylic esters as C-2-synthons with various linker-tethered bisphenols for the construction of medium-sized heterocycles bearing an exocyclic double bond has been developed
The reaction features mild conditions and broad substrate scopes
as well as readily available substrates and catalysts
Under optimal conditions
various medium-sized heterocycles from eight to eleven-membered rings can be afforded in good to excellent yields and regioselectivities with high Z-selectivity for the exocyclic double bond
palladium
medium-sized ring
propargylic ester
bisphenol
cycloaddition
Palladium-catalyzed propargylic [n+2] cycloaddition: an efficient strategy for construction of benzo-fused medium-sized heterocycles
期刊论文
iSwitch采集
Advanced synthesis & catalysis, 2019, 卷号: 361, 期号: 4, 页码: 836-841
作者:
Liu, Zhen-Ting
;
Hu, Xiang-Ping
收藏
  |  
浏览/下载:90/0
  |  
提交时间:2019/05/08
A regioselective palladium-catalyzed formal [n+2] cycloaddition of propargylic esters as c-2-synthons with various linker-tethered bisphenols for the construction of medium-sized heterocycles bearing an exocyclic double bond has been developed
The reaction features mild conditions and broad substrate scopes
As well as readily available substrates and catalysts
Under optimal conditions
Various medium-sized heterocycles from eight to eleven-membered rings can be afforded in good to excellent yields and regioselectivities with high z-selectivity for the exocyclic double bond
Palladium
Medium-sized ring
Propargylic ester
Bisphenol
Cycloaddition
Structure and Physiological Regulation of AMPK
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 卷号: 19, 期号: 11
作者:
Yan, Yan
;
Zhou, X. Edward
;
Xu, H. Eric
;
Melcher, Karsten
  |  
收藏
  |  
浏览/下载:94/0
  |  
提交时间:2019/01/08
energy metabolism
AMPK
activation loop
AID
-linker
-linker
CBS
LKB1
CaMKK2
RIM
Advances in the study of the mechanochemical coupling of kinesin
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF MODERN PHYSICS B, 2018, 卷号: 32, 期号: 18, 页码: 1840001
作者:
Li, M
;
Ou-Yang, ZC
;
Shu, YG
  |  
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2018/12/27
SQUID GIANT-AXON
BOVINE BRAIN KINESIN
HAND-OVER-HAND
CRYSTAL-STRUCTURE
MOTOR DOMAIN
NECK LINKER
8-NM STEP
MOLECULAR MOTORS
OPTICAL-TRAP
FORCE