中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [3]
西双版纳热带植物园 [1]
大连化学物理研究所 [1]
昆明植物研究所 [1]
上海生物化学与细胞生... [1]
采集方式
OAI收割 [7]
内容类型
期刊论文 [7]
发表日期
2017 [1]
2011 [4]
2009 [1]
2001 [1]
学科主题
Biochemist... [1]
Plant Scie... [1]
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Discovery of alkyl bis(oxy)dibenzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors
期刊论文
OAI收割
CHEMICAL BIOLOGY & DRUG DESIGN, 2017, 卷号: 90, 期号: 6, 页码: 1260-1270
作者:
Zhang, Wei-yao
;
Lu, Wen-chao
;
Jiang, Hao
;
Lv, Zheng-bing
;
Xie, Yi-qian
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/01/08
epigenetics
molecular docking
PRMT1
scaffold hopping
small-molecule inhibitor
Insight into the Structural Requirements of Benzothiadiazine Scaffold-Based Derivatives as Hepatitis C Virus NS5B Polymerase Inhibitors Using 3D-QSAR, Molecular Docking and Molecular Dynamics
期刊论文
OAI收割
current medicinal chemistry, 2011, 卷号: 18, 期号: 26, 页码: 4019-4028
作者:
Zhang, H-X.
;
Li, Y.
;
Wang, X.
;
Xiao, Z-T.
;
Wang, Y-H.
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2015/11/12
HCV NS5B
benzothiadiazine scaffold-based inhibitors
3D-QSAR
CoMFA
CoMSIA
molecular docking
molecular dynamics
Click to a focused library of benzyl 6-triazolo(hydroxy)benzoic glucosides: Novel construction of PTP1B inhibitors on a sugar scaffold
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 卷号: 46, 期号: 9, 页码: 4212-4218
作者:
Li, Cui
;
He, Xiao-Peng
;
Zhang, Yin-Jie
;
Li, Zhen
;
Gao, Li-Xin
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
Click chemistry
PTP1B inhibitor
Sugar scaffold
(Hydroxy)benzoate
Molecular docking
Integrating fossils in a molecular-based phylogeny and testing them as calibration points for divergence time estimates in Menispermaceae
期刊论文
OAI收割
JOURNAL OF SYSTEMATICS AND EVOLUTION, 2011, 卷号: 49, 期号: 1, 页码: 25-49
作者:
Zhou, ZK
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2012/05/24
age calibration
cross-validation
fossil
Menispermaceae
molecular scaffold
phylogeny
Integrating fossils in a molecular-based phylogeny and testing them as calibration points for divergence time estimates in Menispermaceae
期刊论文
OAI收割
JOURNAL OF SYSTEMATICS AND EVOLUTION, 2011, 卷号: 49, 期号: 1, 页码: 25-49
作者:
Jacques, Frederic M. B.
;
Wang, Wei
;
Ortiz, Rosa Del C.
;
Li, Hong-Lei
;
Zhou, Zhe-Kun
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2012/03/16
Age Calibration
Cross-validation
Fossil
Menispermaceae
Molecular Scaffold
Phylogeny
ScafBank: a public comprehensive Scaffold database to support molecular hopping
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2009, 卷号: 30, 期号: 2, 页码: 251-258
作者:
Yan, Bi-bo
;
Xue, Meng-zhu
;
Xiong, Bing
;
Liu, Ke
;
Hu, Ding-yu
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
chemoinformatics
privileged structure
scaffold database
molecular hopping
Toward understanding the role of insulin alpha-helix II in the growth-promoting activity of insulin
期刊论文
OAI收割
BIOLOGICAL CHEMISTRY, 2001, 卷号: 382, 期号: 7, 页码: 1057-1062
作者:
Chen, H
;
Feng, YM
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2015/07/22
growth-promoting activity
insulin
insulin-like growth factor 1 (IGF-1)
molecular scaffold
structural motif