中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [3]
新疆理化技术研究所 [1]
大连化学物理研究所 [1]
采集方式
OAI收割 [5]
内容类型
期刊论文 [5]
发表日期
2018 [1]
2015 [1]
2013 [2]
2012 [1]
学科主题
Chemistry [1]
Pharmacolo... [1]
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Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetyicholinesterase (AChE) and Phosphodiesterase 5 (PDE5)
期刊论文
OAI收割
ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 7, 页码: 1625-1636
作者:
Ni, Wei
;
Wang, Huan
  |  
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2019/01/08
Multifunctional agents
AChE inhibitors
PDE5 inhibitors
Alzheimer's disease
preclinicalpharmacokineticsoftpn729maanovelpde5inhibitorandpredictionofitshumanpharmacokineticsusingapbpkmodel
期刊论文
OAI收割
actapharmacologicasinica, 2015, 卷号: 36, 期号: 12, 页码: 1528
作者:
Gao Zhiwei
;
Zhu Yunting
;
Yu Mingming
;
Zan Bin
;
Liu Jia
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
HUMAN DRUG CLEARANCE
PHOSPHODIESTERASE-5 INHIBITORS
CLINICAL PHARMACOKINETICS
ERECTILE DYSFUNCTION
TISSUE DISTRIBUTION
ORAL PHARMACOKINETICS
RECEPTOR ANTAGONIST
DIVERSE COMPOUNDS
IN-VIVO
ABSORPTION
TPN729MA
PDE5 inhibitor
erectile dysfunction
pharmacokinetics
human PK prediction
physiologically based pharmacokinetic model
Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 卷号: 23, 期号: 17, 页码: 4944-4947
作者:
Gong, Xudong
;
Wang, Guan
;
Ren, Jing
;
Liu, Zheng
;
Wang, Zhen
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
PDE5 inhibitors
5-Bromopyrimidin-4(3H)-ones
Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 卷号: 23, 期号: 17, 页码: 4944-4947
作者:
Gong Xudong
;
Wang Guan
;
Ren Jing
;
Liu Zheng
;
Wang Zhen
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2013/11/07
PDE5 inhibitors
5-Bromopyrimidin-4(3H)-ones
Exploring the structure determinants of pyrazinone derivatives as PDE5 3HC8 inhibitors: An in silico analysis
期刊论文
OAI收割
journal of molecular graphics & modelling, 2012, 卷号: 38, 页码: 112-122
作者:
Li, Yan
;
Wu, Wenzhao
;
Ren, Hong
;
Wang, Jinghui
;
Zhang, Shuwei
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2015/11/13
PDE5
Pyrazinone-based inhibitors
3D-QSAR
Molecular docking
Molecular dynamics