中国科学院机构知识库网格
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Strategic Amino Acid Mutations in CPD Cleavage Motif: Impacts on Hydrolysis and C-Terminal Modification Efficiency
期刊论文
OAI收割
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2025, 卷号: 41, 期号: 3, 页码: 592-600
作者:
Yashinov, Ansor
;
Zou, Xiangman
;
Hang, Jiayin
;
Liu, Zhi
;
Song, Fengnan
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2025/06/23
Protein engineering
C-Terminal modification
Cysteine protease domain
Self-cleavage tag
AlphaFold2
Insights into the mechanism of ameliorative antioxidant activity and hydration characteristics in cold plasma-induced glycosylated peanut protein products
期刊论文
OAI收割
FOOD CHEMISTRY, 2025, 卷号: 473, 页码: 9
作者:
Yu, Jiao-jiao
;
Zhang, Ran-ran
;
Yang, Da-Qiao
;
Lin, Xiang-na
;
Fu, Wen-jie
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2025/05/09
Cold plasma
Peanut protein
Sesbania gum
Visual analysis
First ATG101-recruiting small molecule degrader for selective CDK9 degradation
via
autophagy-lysosome pathway
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 5, 页码: 2612-2624
作者:
Zhong, Ye
;
Xu, Jing
;
Cao, Huiying
;
Gao, Jie
;
Ding, Shaoyue
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2025/07/25
Protein degradation
Hydrophobic tags
ATG101
Autophagy-lysosome pathway
CDK9
Cyclin T1
Degrader
Antitumor
Unveiling p65 as the target of diphyllin in ameliorating metabolic dysfunction-associated steatotic liver disease via targeted protein degradation technology
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2025, 卷号: 16, 页码: 12
作者:
Zhu, Xuejing
;
Zhang, Lei
;
Cui, Wenqian
;
Wang, Liangjie
;
Xu, Fengjing
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2025/07/25
metabolic dysfunction-associated steatotic liver disease
diphyllin
p65
targeted protein degradation technology
NRF2
Proteome-Wide Data Guides the Discovery of Lysine-Targeting Covalent Inhibitors Using DNA-Encoded Chemical Libraries
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 14
作者:
Wu, Xinyuan
;
Li, Shunyao
;
Liang, Ting
;
Yu, Qing
;
Zhang, Yiwei
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2025/06/23
Activity-based protein profiling data
Covalent DNA-encoded chemical library
Covalent ligand selection
Lysine-targeting covalent inhibitors
Structural basis of the cysteinyl leukotriene receptor type 2 activation by LTD4
期刊论文
OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2025, 卷号: 122, 期号: 15, 页码: 9
作者:
Jiang, Mengting
;
Xu, Youwei
;
Luan, Xiaodong
;
Wu, Kai
;
Li, Zhen
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2025/06/23
G protein-coupled receptor
cryo-electron microscopy
cysteinyl leukotriene receptor2
activation mechanism
G alpha q protein coupling
Cross-Linking Profiling of Molecular Glue Degrader-Induced E3 Ligase Interactome to Expand Target Space
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 13
作者:
Xu, Yali
;
Zhao, Wensi
;
Nie, Hui-Jun
;
Wang, Jiamin
;
Fu, Jingjing
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/05/27
Chemoproteomics
Genetic code expansion
Molecular glue degrader
Photo-crosslinking
Targeted protein degradation
Dynamic Cap-Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease
期刊论文
OAI收割
ADVANCED SCIENCE, 2025, 页码: 13
作者:
Su, Haixia
;
Wu, Guoqing
;
Xiong, Muya
;
Wang, Yuhang
;
Cao, Junyuan
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2025/05/27
covalent inhibitors
I7L protease
monkeypox virus
protein structures
substrate proteolysis
Discovery of 2,4-quinazolinedione derivatives as LC3B recruiters in the facilitation of protein complex degradations
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 287, 页码: 10
作者:
Zeng, Yanping
;
Xiao, Jian
;
Shi, Li
;
Li, Yangsha
;
Xu, Yuanxin
  |  
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2025/04/01
LC3B
CDK9
Degradation
Protein complex
Bicyclic polyprenylated acylphloroglucinol-related meroterpenoids as potent DRAK2 inhibitors from
Hypericum patulum
期刊论文
OAI收割
PHYTOCHEMISTRY, 2025, 卷号: 232, 页码: 10
作者:
Huang, Jin-Chang
;
Jia, Xin-Yu
;
Lv, Yi-Fan
;
Xu, Hong-Hong
;
Han, Ming
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2025/04/01
Hypericum patulum
Hypericaceae
Meroterpenoids
Hyperpatins A-H
Death-associated protein kinase-related
apoptosis-inducing kinase 2
Glucose-stimulated insulin secretion