中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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UuPGRP, a peptidoglycan recognition protein of Urechis unicinctus, promotes immune defense against bacterial infection
期刊论文
OAI收割
FISH & SHELLFISH IMMUNOLOGY, 2026, 卷号: 172, 页码: 12
作者:
Qiu, Yulie
;
Shi, Chenxi
;
Li, Xupeng
;
Jiao, Xudong
;
Zhang, Jian
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2026/04/14
Urechis unicinctus
Peptidoglycan recognition protein
Reactive oxygen species
Innate immunity
Structural Remodeling and Enzymatic Replacement Shape the Evolution of Organellar Group II Introns in
Ulva
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2026, 卷号: 27, 期号: 6, 页码: 24
作者:
Liu, Feng
;
Jin, Shuangle
;
Song, Huiyin
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2026/06/02
group II introns
Ulva
organellar genomes
reverse transcriptase/maturase
LAGLIDADG homing endonuclease
RNA structure evolution
intron-protein coevolution
Discovery of novel and potent harringtonine derivative P2 via systematic structure-activity Optimization: Semi-Synthesis, anti-leukemia activity, and mechanism study
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2026, 卷号: 305, 页码: 23
作者:
Xu, Zhongli
;
Shen, Shuting
;
Ding, Xinyu
;
Wang, Xiaoyu
;
Zhang, Dejin
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2026/04/01
Harringtonine derivative
Homoharringtonine (HHT)
Structure-activity relationship
Anti-leukemic activity
Molecular docking
Protein synthesis inhibitor
Ultra-bright near-infrared reporters-embedded SERS nanotags library for single-animal multiplex monitoring protein-specific nanomaterial fate in vivo
期刊论文
OAI收割
SENSORS AND ACTUATORS B-CHEMICAL, 2026, 卷号: 448, 页码: 9
作者:
Mei, Rongchao
;
Wang, Yunqing
;
Zhao, Xizhen
;
Wang, Qishuo
;
Wang, Xiaoyan
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/12/10
SERS tags
NIR reporters
Au shell
Multiple detection
Protein crowns
Optimizing computational prediction of shrimp-WSSV protein interactions through integration of homology- and topology-based predictions
期刊论文
OAI收割
MOLECULAR GENETICS AND GENOMICS, 2026, 卷号: 301, 期号: 1, 页码: 10
作者:
Yang, Zhanyuan
;
Yuan, Jianbo
;
Li, Shihao
;
Zhang, Xiaojun
;
Li, Fuhua
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2026/06/02
Protein-protein interactions
Penaeid shrimp
STRING interaction
AlphaFold3 modeling
Molecular dynamics simulations
The viscoelastic living matter from biomolecular condensates to tissues: Comment on "viscoelastic mechanics of living cells" by Zhou et al
期刊论文
OAI收割
PHYSICS OF LIFE REVIEWS, 2025, 卷号: 55, 页码: 52-54
作者:
Guan DS(关东石)
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2025/09/29
Viscoelasticity
Protein condensates
Cell mechanics
Tissues
Power-law rheology
Cavity engineering-driven switching of cofactor specificity in a carbonyl reductase for the synthesis of chiral aryl β-Hydroxy α-amino acid
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 167, 页码: 9
作者:
Tang, Jiawei
;
Zhong, Jirui
;
Chen, Hao
;
Zhang, Luwen
;
Shao, Junxi
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2026/01/29
Carbonyl reductases
Protein engineering
Cofactor specificity reversal
Chiral aryl beta-hydroxy alpha-amino acids
Biocatalysis
Rational engineering of degradation tail-driven CELMoD-antibody conjugates for precision malignancy therapy
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 12, 页码: 6510-6528
作者:
Guo, Yu
;
Song, Yi
;
Wang, Hanlin
;
Lu, Yang
;
Zhang, Jingyu
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2026/01/29
Degrader-antibody conjugate
Antibody-drug conjugate
Cereblon E3 ligase modulator
Immunomodulatory drug
Molecular glue
Targeted protein degradation
Multiple myeloma
Hematologic malignancy
Bioactivity-based molecular networking-guided identification of methyl rosmarinate from
Orthosiphon
aristatus
as a PTP1B inhibitor that improves insulin sensitivity in diabetic mice
期刊论文
OAI收割
PHYTOMEDICINE, 2025, 卷号: 148, 页码: 14
作者:
Xie, Bojun
;
Zhu, Dafu
;
Li, Linxuan
;
Lou, Ruohan
;
Wang, Rui
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2025/12/04
Type 2 diabetes
Bioactivity-based molecular networking
Protein tyrosine phosphatase 1B
Orthosiphon aristatus
Methyl rosmarinate
Insulin sensitivity
Targeting p53 activation: Recent therapeutic advances in cancer and diabetic macular edema
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 297, 页码: 20
作者:
Wang, Zhiyi
;
Zhang, Shijie
;
Irakoze, Loica Melita
;
Zhao, Yujun
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/12/04
p53
MDM2
Protein-protein interaction
Mutant p53
Gene therapy
PROTAC
Degrader