中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [16]
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Cross-Linking Profiling of Molecular Glue Degrader-Induced E3 Ligase Interactome to Expand Target Space
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 13
作者:
Xu, Yali
;
Zhao, Wensi
;
Nie, Hui-Jun
;
Wang, Jiamin
;
Fu, Jingjing
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/05/27
Chemoproteomics
Genetic code expansion
Molecular glue degrader
Photo-crosslinking
Targeted protein degradation
Discovery of 2,4-quinazolinedione derivatives as LC3B recruiters in the facilitation of protein complex degradations
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 287, 页码: 10
作者:
Zeng, Yanping
;
Xiao, Jian
;
Shi, Li
;
Li, Yangsha
;
Xu, Yuanxin
  |  
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2025/04/01
LC3B
CDK9
Degradation
Protein complex
Self-Oxygenating PROTAC Microneedle for Spatiotemporally-Confined Protein Degradation and Enhanced Glioblastoma Therapy
期刊论文
OAI收割
ADVANCED MATERIALS, 2025, 页码: 13
作者:
Jiang, Xingyu
;
Lai, Yi
;
Xia, Wenzheng
;
Yang, Wenfang
;
Wang, Junjue
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/04/24
acid-activatable photodynamic therapy
double-layered microneedle
glioblastoma therapy
light-activatable PROTAC prodrug
protein degradation
Discovery of SET domain-binding primary alkylamine-tethered degraders for the simultaneous degradation of NSD2-long and RE-IIBP isoforms
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 283, 页码: 17
作者:
Hu, Linghao
;
Xu, Hesong
;
Xu, Ye
;
Chen, Haowen
;
Jiang, Hanrui
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2025/04/01
NSD2
RE-IIBP
Targeted protein degradation
Multiple myeloma
Efficient biodegradation of poly(butylene adipate-co-terephthalate) in mild temperature by cutinases derived from a marine fungus
期刊论文
OAI收割
JOURNAL OF HAZARDOUS MATERIALS, 2024, 卷号: 480, 页码: 12
作者:
Fei, Fan
;
Su, Zhenjie
;
Liu, Rui
;
Gao, Rongrong
;
Sun, Chaomin
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/12/20
PBAT degradation
Marine fungus
Cutinase
Mild temperature
Protein engineering
An overview of PROTACs targeting MDM2 as a novel approach for cancer therapy
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 272, 页码: 8
作者:
Li, Huiwen
;
Cai, Xinhui
;
Yang, Xiaoyu
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2024/09/26
MDM2
PROTAC
p53
MDMX
Targeted protein degradation
Accelerating PROTACs Discovery Through a Direct-to-Biology Platform Enabled by Modular Photoclick Chemistry
期刊论文
OAI收割
ADVANCED SCIENCE, 2024, 页码: 12
作者:
Yan, Ke-Nian
;
Nie, Yong-Qiang
;
Wang, Jia-Yu
;
Yin, Guang-Liang
;
Liu, Qia
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/05/31
High-throughput chemical synthesis
modular synthesis
photoclick chemistry
PROTACs library
targeted protein degradation
Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 12
作者:
Zou, Zhi-feng
;
Yang, Lei
;
Nie, Hui-jun
;
Gao, Jing
;
Lei, Shu-min
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2024/05/22
proteolysis-targeting chimeras
tumor-targeted delivery
precise protein degradation
combination therapy
triple-negative breast cancer
Enzymatic Degradation of Deoxynivalenol with the Engineered Detoxification Enzyme Fhb7
期刊论文
OAI收割
JACS AU, 2024, 卷号: 4, 期号: 2, 页码: 619-634
作者:
Yang, Jun
;
Liang, Kai
;
Ke, Han
;
Zhang, Yuebin
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/06/04
deoxynivalenol degradation
Fhb7
thermal stability
consensus sequence
protein engineering
syntheticbiology
Fusarium head blight
Discovery of HyT-Based Degraders of CDK9-Cyclin T1 Complex
期刊论文
OAI收割
CHEMISTRY & BIODIVERSITY, 2023, 页码: 10
作者:
Lin, Rongkun
;
Yang, Jie
;
Liu, Ting
;
Wang, Mingyu
;
Ke, Chongrong
  |  
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2023/10/17
CDK9
cyclin T1
degrader
hydrophobic tag
protein degradation