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浏览/检索结果: 共95条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Discovery of pyridazinone derivatives bearing tetrahydroimidazo[1,2- a ] pyrazine scaffold as potent inhibitors of transient receptor potential canonical 5 to ameliorate hypertension-induced renal injury in rats 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 275, 页码: 18 作者:  Xu, Yuanyuan;  Ren, Younan;  Zhang, Jie;  Niu, Bo;  Liu, Mengru   |  收藏  |  浏览/下载：6/0  |  提交时间：2024/08/22 Pyridazinone  Tetrahydroimidazo[1,2-a]pyrazine  Transient receptor potential canonical 5  Chronic kidney disease  Focal segmental glomerulosclerosis   The antidepressant-like effect and proposed mechanism of action of TPN672MA, a novel serotonin-dopamine receptor modulator for the treatment of schizophrenia 期刊论文  OAI收割 PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2024, 卷号: 242, 页码: 13 作者:  Cheng, Jiaxin;  Wu, Chunhui;  Wang, Yu;  Wang, Zhen;  He, Yang   |  收藏  |  浏览/下载：10/0  |  提交时间：2024/09/24 TPN672MA  5-HT 1A receptor agonist  D 2 /D 3 receptor partial agonist  5-HT 2A receptor antagonist  Antidepressant-like  Mechanism   Structural basis for activation of somatostatin receptor 5 by cyclic neuropeptide agonists 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2024, 卷号: 121, 期号: 26, 页码: 10 作者:  Li, Jingru;  You, Chongzhao;  Li, Yang;  Li, Changyao;  Fan, Wenjia   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/08/22 SSTR5  peptide agonists  agonist selectivity  receptor activation   Cannabidiol exhibits anxiolytic-like effects and antipsychotic-like effects in mice models 期刊论文  OAI收割 NEUROSCIENCE LETTERS, 2024, 卷号: 826, 页码: 8 作者:  Shu, Guangzhao;  He, Yang;  Suo, Jin;  Wu, Chunhui;  Gong, Xudong   |  收藏  |  浏览/下载：28/0  |  提交时间：2024/06/27 Cannabidiol  Stress-induced hyperthermia  Phencyclidine-induced negative symptoms of  schizophrenia model  5-HT 1A receptor   Vertical changes of PM2.5 driven by meteorology in the atmospheric boundary layer during a heavy air pollution event in central China 期刊论文  OAI收割 SCIENCE OF THE TOTAL ENVIRONMENT, 2023, 卷号: 858, 页码: 10 作者:  Sun, Xiaoyun;  Zhao, Tianliang;  Tang, Guiqian;  Bai, Yongqing;  Kong, Shaofei   |  收藏  |  浏览/下载：19/0  |  提交时间：2024/08/21 ABL  RegionalPM2  5 transport  Receptor region  Heavy air pollution   New monoamine antidepressant, hypidone hydrochloride (YL-0919), enhances the excitability of medial prefrontal cortex in mice via a neural disinhibition mechanism 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11 作者:  Zhang, Yong-Mei;  Ye, Lu-Yu;  Li, Tian-Yu;  Guo, Fan;  Guo, Fei   |  收藏  |  浏览/下载：37/0  |  提交时间：2022/01/04 YL-0919  medial prefrontal cortex  GABAergic neurons  5-HT1A receptor  GAD67-GFP transgenic mice  disinhibition  fluoxetine  electrophysiological recording   PARP14 inhibits microglial activation via LPAR5 to promote post-stroke functional recovery 期刊论文  OAI收割 AUTOPHAGY, 2021, 卷号: 17, 期号: 10, 页码: 2905-2922 作者:  Tang, Ying;  Liu, Jinchang;  Wang, Yu;  Yang, Li;  Han, Bing   |  收藏  |  浏览/下载：52/0  |  提交时间：2022/01/04 Autophagy  functional recovery  ischemic stroke  lysophosphatidic acid receptor 5  microglial activation  poly (ADP-ribose) polymerase 14   Inositol polyphosphate multikinase IPMK-1 regulates development through IP3/calcium signaling in Caenorhabditis elegans 期刊论文  OAI收割 CELL CALCIUM, 2021, 卷号: 93, 页码: 102327 作者:  Yang,Zhong-Lin;  Chen,Jian-Ning;  Lu,Yu-Yang;  Lu,Min;  Wan,Qin-Li   |  收藏  |  浏览/下载：44/0  |  提交时间：2022/04/02 Inositol polyphosphates  Inositol polyphosphate multikinase  Type I inositol 5-phosphatase  Development  Calcium signaling  Defecation rhythm  C. elegans  C-ELEGANS  PHOSPHOLIPASE-C  CALCIUM  1,4,5-TRISPHOSPHATE  CALCINEURIN  KINASE  IDENTIFICATION  TRISPHOSPHATE  METABOLISM  RECEPTOR   Synthesis and biological investigation of triazolopyridinone derivatives as potential multireceptor atypical antipsychotics 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 8, 页码: 6 作者:  Shi, Wenqiang;  Wang, Yu;  Wu, Chunhui;  Yang, Feipu;  Zheng, Wei   |  收藏  |  浏览/下载：31/0  |  提交时间：2020/07/01 Triazolopyridinone  Antipsychotic  Multireceptor  5-HT1A receptor   Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure-activity relationship, crystal structural characterization and and in vivo study 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 2, 页码: 351-368 作者:  Wei, Peng;  Liu, Bo;  Wang, Ruifeng   |  收藏  |  浏览/下载：50/0  |  提交时间：2020/07/01 Fibroblast growth factor  Tyrosine kinase receptor  Structure-based  Crystallography  Selectivity  Hybrid  5-Hydrosulfonyl-5H- pyrrolo[2.3-b]pyrazine  Inhibitor