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• Chemistry [8]
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浏览/检索结果: 共275条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Discovery of novel covalent stabilizers for p53 Y220C using structure-based drug discovery methods 期刊论文  OAI收割 MOLECULAR DIVERSITY, 2025, 页码: 14 作者:  Wen, Yiming;  Xu, Peijia;  Chen, Yijie;  Meng, Jingyi;  Zheng, Mingyue   |  收藏  |  浏览/下载：7/0  |  提交时间：2025/04/01 p53 Y220C  Covalent stabilizer  Virtual screening  Molecular dynamics  DNA binding  Structure-activity relationship  Cancer therapy   Design, synthesis and biological evaluation of Alisol B derivatives for potential treatment of non-alcoholic steatohepatitis 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2025, 卷号: 155, 页码: 15 作者:  Yu, Nai-Rong;  Huang, Suling;  Deng, Zhen-Tao;  Wang, Jiayue;  Shen, Yu   |  收藏  |  浏览/下载：8/0  |  提交时间：2025/04/01 Non-alcoholic steatohepatitis (NASH)  Alisol B  Structural modification  Structure-activity relationship  HFD+CCl4-induced NASH mice model   Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c] pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 438-466 作者:  Li, Yang;  Fang, Yan;  Chen, Xiaoyu;  Tong, Linjiang;  Feng, Fang   |  收藏  |  浏览/下载：10/0  |  提交时间：2025/04/01 P21-activated kinase 4  Tetrahydrobenzofuro[2  3-c]pyridine  Structure-activity relationship  Allosteric inhibitor  Pharmacokinetics properties  Kinase selectivity  Pancreatic cancer  Immune infiltration   Cytotoxic diterpenoids from Croton kongensis inhibiting tumor proliferation and migration 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 152, 页码: 15 作者:  Zhu, Qiong;  Li, Ying;  Wang, Chenglei;  Yu, Jinhai;  Yue, Jianmin   |  收藏  |  浏览/下载：14/0  |  提交时间：2024/10/21 Croton kongensis  ent-Kauranes  Structural elucidation  Structure-activity relationship  Anticancer mechanism   Intriguing steroid glycosides for cancer therapy by suppressing the DNA damage response and mTOR/S6K signaling pathways 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 151, 页码: 14 作者:  An, Pei-Pei;  Huang, Hui;  Ru, Su-Jie;  Gao, Yuan;  Ren, Yu-Hao   |  收藏  |  浏览/下载：90/0  |  提交时间：2024/09/26 Strophanthus divaricatus  Steroid glycosides  Structural elucidation  Structure-activity relationship  Anticancer mechanism   Anti-HBV Activities of Cembranoids from the South China Sea Soft Coral Sinularia pedunculata and Their Structure Activity Relationship 期刊论文  OAI收割 CHEMISTRY & BIODIVERSITY, 2024, 页码: 8 作者:  Huang, Chao;  Jin, Yang;  Sun, Ruo-Nan;  Hu, Kong-Ying;  Yao, Li-Gong   |  收藏  |  浏览/下载：70/0  |  提交时间：2024/08/22 Hepatitis B Virus  cembranoid  anti-HBV activity  structure-activity relationship  ENI/Xp enhancer/promoter   Structural and functional characteristics of pectins from three cultivars of apple ( Malus pumila Mill.) pomaces 期刊论文  OAI收割 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 卷号: 269, 页码: 14 作者:  Guo, Huan;  Li, Hang;  Ran, Wenyi;  Yu, Wenyue;  Xiao, Yue   |  收藏  |  浏览/下载：3/0  |  提交时间：2024/08/29 Apple pectin  Immunostimulatory activity  Structure -function relationship   A novel approach to exploit Small-Molecule glucagon-like Peptide-1 receptor agonists with high potency 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 卷号: 107, 页码: 19 作者:  Wang, Xiaoyan;  Yun, Ying;  Chen, Lili;  Guo, Shimeng;  Niu, Buying   |  收藏  |  浏览/下载：31/0  |  提交时间：2024/07/12 Diabetes  GLP-1 receptor  Agonist  Structural optimization  Water molecule replacement  Structure activity relationship  Docking simulation   Fatty acid esters of hydroxy fatty acids: A potential treatment for obesity-related diseases 期刊论文  OAI收割 OBESITY REVIEWS, 2024, 页码: 11 作者:  Li, Lili;  Wang, Ping;  Jiao, Xudong;  Qin, Song;  Liu, Zhengyi   |  收藏  |  浏览/下载：7/0  |  提交时间：2024/10/28 adipose tissue  diabetes  fatty acid esters of hydroxy fatty acids  inflammation  structure-activity relationship   Fatty acid esters of hydroxy fatty acids: A potential treatment for obesity-related diseases 期刊论文  OAI收割 OBESITY REVIEWS, 2024, 页码: 11 作者:  Li, Lili;  Wang, Ping;  Jiao, Xudong;  Qin, Song;  Liu, Zhengyi   |  收藏  |  浏览/下载：12/0  |  提交时间：2024/05/07 adipose tissue  diabetes  fatty acid esters of hydroxy fatty acids  inflammation  structure-activity relationship