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Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [2]
南海海洋研究所 [1]
金属研究所 [1]
化学研究所 [1]
西北高原生物研究所 [1]
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期刊论文 [8]
学位论文 [1]
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2011 [5]
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人参皂苷 CK 衍生物和黄酮糖苷的合成及活性研究
学位论文
OAI收割
北京: 中国科学院大学;中国科学院生态环境研究中心, 2021
作者:
尚呈翔
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2022/06/20
人参皂苷 Ck,抗肿瘤,夏佛塔苷,降血糖,计算机辅助药物设计
ginsenoside Ck, Anti-tumor, Shaftaside, Anti-diabetic, Computer Aided Drug Design (Cadd)
Facile and ultrasensitive fluorescence sensor platform for tumor invasive biomaker beta-glucuronidase detection and inhibitor evaluation with carbon quantum dots based on inner-filter effect
期刊论文
OAI收割
biosensors & bioelectronics, 2016, 卷号: 85, 页码: 358-362
作者:
Lu, Shuaimin
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2016/12/19
beta-glucuronidase
Nitrogen-doped carbon quantum dots
Inner-filter effect
Anti-tumor drug screening
The use of hollow mesoporous silica nanospheres to encapsulate bortezomib and improve efficacy for non-small cell lung cancer therapy
期刊论文
OAI收割
BIOMATERIALS, 2014, 卷号: 35, 期号: 1, 页码: 316-326
作者:
Shen, J
;
Song, GS
;
An, M
;
Li, XQ
;
Wu, N
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2015/07/22
Anti-tumor activity
Apoptotic cell death
Bortezomib
Drug delivery
Mesoporous silica
NSCLC
Construction of amphiphilic copolymer nanoparticles based on hyperbranched poly (amine-ester) and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine as drug carriers for cancer therapy
期刊论文
iSwitch采集
Nanomedicine-nanotechnology biology and medicine, 2011, 卷号: 7, 期号: 6, 页码: 945-954
作者:
Wu, Yan
;
Jiao, Fang
;
Han, Siyuan
;
Fan, Tengfei
;
Liu, Ying
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/04/23
Drug delivery
Controlled drug release
Hyperbranched copolymer
Anti-tumor activity
Biocompatibility
Ligand-Based Structural Optimization of Grb2-SH2 Inhibitors: High Affinity, Low Charge and Reduced Peptidic Nature
期刊论文
OAI收割
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2011, 卷号: 31, 期号: 12, 页码: 2019-2033
作者:
Peng Dian
;
Zhi Ying
;
Xue Ting
;
Gao Huiyuan
;
Long Yaqiu
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
phosphotyrosine
Grb2-SH2 inhibitor
structure-activity relationship
mitogenic ras pathway
anti-tumor drug
Biodegradable polymer - cisplatin(IV) conjugate as a pro-drug of cisplatin(II)
期刊论文
OAI收割
BIOMATERIALS, 2011, 卷号: 32, 期号: 30, 页码: 7732-7739
作者:
Xiao, Haihua
;
Qi, Ruogu
;
Liu, Shi
;
Hu, Xiuli
;
Duan, Taicheng
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/04/09
Cisplatin
Platinum Anti-tumor Drugs
Polymer-drug Conjugate
Cancer Therapy
Drug Delivery
基于配体结构的grb2sh2抑制剂的结构优化更高的活性更少的电荷更低的肽性
期刊论文
OAI收割
有机化学, 2011, 卷号: 31, 期号: 12, 页码: 2019
作者:
彭电
;
智英
;
薛婷
;
高慧媛
;
龙亚秋
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/07/01
STRUCTURE-BASED DESIGN
RING-CLOSING METATHESIS
CONSTRAINED PHOSPHOTYROSYL MIMETICS
DOMAIN-BINDING MACROCYCLES
ALPHA-AMINO-ACIDS
SH2 DOMAIN
NONPHOSPHORYLATED INHIBITOR
PHOSPHOPEPTIDE LIGANDS
TYROSINE DERIVATIVES
SIGNAL-TRANSDUCTION
phosphotyrosine
Grb2-SH2 inhibitor
structure-activity relationship
mitogenic ras pathway
anti-tumor drug
Ligand-Based Structural Optimization of Grb2-SH2 Inhibitors: High Affinity, Low Charge and Reduced Peptidic Nature
期刊论文
OAI收割
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2011, 卷号: 31, 期号: 12, 页码: 2019-2033
作者:
Peng Dian
;
Zhi Ying
;
Xue Ting
;
Gao Huiyuan
;
Long Yaqiu
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2021/07/23
STRUCTURE-BASED DESIGN
RING-CLOSING METATHESIS
SH2 DOMAIN
NONPHOSPHORYLATED INHIBITOR
PHOSPHOTYROSYL MIMETICS
ACID-RESIDUES
BINDING
ANTAGONISTS
POSITION
REQUIREMENTS
phosphotyrosine
Grb2-SH2 inhibitor
structure-activity relationship
mitogenic ras pathway
anti-tumor drug
Microbial biotransformation of water-insoluble herbimycin A to 11-hydroxy-(11-demethoxy)-herbimycin C by Eupenicillium sp SD017
期刊论文
OAI收割
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2010, 卷号: 62, 期号: 1, 页码: 76-80
作者:
Xie, LW
;
Wang, GH
;
Zhang, H
;
Ouyang, YC
;
Sun, W
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收藏
  |  
浏览/下载:31/0
  |  
提交时间:2011/07/02
Herbimycin a
Biotransformation
Water-insoluble Anti-tumor Drug
O-demethylase