中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
机构
采集方式
内容类型
发表日期
学科主题
筛选

浏览/检索结果: 共27条,第1-10条 帮助

条数/页: 排序方式:
Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels 期刊论文  OAI收割
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 31, 页码: 10842-10856
作者:  
Liu, Wen;  Yin, Ye;  Wang, Meijing;  Fan, Ting;  Zhu, Yuyu
  |  收藏  |  浏览/下载:98/0  |  提交时间:2020/12/24
microRNA-149 targets caspase-2 in glioma progression 期刊论文  OAI收割
ONCOTARGET, 2016, 卷号: 7, 期号: 18, 页码: 26388-26399
作者:  
Shen, Xiaokun;  Li, Jie;  Liao, Wenfeng;  Wang, Jiwen;  Chen, Huanjun
  |  收藏  |  浏览/下载:29/0  |  提交时间:2019/01/08
FS-108,an Hsp90 inhibitor,impairs survival and motility of oncogene addicted cancer cells 期刊论文  OAI收割
Chinese Pharmacological Bulletin, 2016, 卷号: 32, 期号: 10, 页码: 1357-1363
作者:  
Ping Fangfang;  Wang Yueqin;  Zhang Minmin;  Shi Feng;  Chen Danqi
  |  收藏  |  浏览/下载:32/0  |  提交时间:2019/01/08
Ca2+ and caspases are involved in hydroxyl radical-induced apoptosis in erythrocytes of Jian carp (Cyprinus carpio var. Jian) 期刊论文  OAI收割
FISH PHYSIOLOGY AND BIOCHEMISTRY, 2015, 卷号: 41, 期号: 5, 页码: 1305-1319
作者:  
Li, HuaTao;  Feng, Lin;  Jiang, WeiDan;  Liu, Yang;  Jiang, Jun
收藏  |  浏览/下载:36/0  |  提交时间:2015/11/05
High-dose thalidomide increases the risk of peripheral neuropathy in the treatment of ankylosing spondylitis 期刊论文  OAI收割
Neural Regeneration Research, 2015, 卷号: 10, 期号: 5, 页码: 814-818
作者:  
Xue Hongxia;  Fu Wenyi;  Cui Huadong;  Yang Lili;  Zhang Ning
  |  收藏  |  浏览/下载:29/0  |  提交时间:2021/02/02
active zone stability  Drosophila  neuromuscular junction  dephosphorylation  Liprin-α  Syd-1  PP2A  GSK-3?  living scaffolds  neural tissue engineering  cell transplant  biomaterials  regeneration  neurotrauma  neurodegeneration  axon pathfinding  cell migration  injury  plasticity  neurodegenerative disease  brain  therapy  neuron  microglia  neural progenitor  tissue engineering  neuroregeneration  repair  central nervous system  biomaterial  regenerative medicine  nanotechnology  spinal cord injury  axonal regeneration  exosome  extracellular vesicle  microRNA  microvesicle  nerve gap  neurite outgrowth  peripheral nerve injury  Schwann cell  stem cell  hemodynamic phases  cerebral subarachnoid hemorrhage  metabolic crises  nerve regeneration  hypoxic-ischemic brain damage  ginsenoside Rg1  neural stem cells  cell transplantation  cell differentiation  cognition  nerve reconstruction  neural regeneration  nerve regeneration  brain injury  neuroimaging  functional magnetic resonance imaging  regional homogeneity  apoplexy  subacute  ischemia  participants  healthy  volunteers  brain activity  NSFC grants  neural regeneration  nerve regeneration  brain injury  neuroprotection  cerebral ischemia/reperfusion injury  lateral intracerebroventricular injection  Apelin-13  nerve apoptosis  Bcl-2  caspase-3  NSFC grants  neural regeneration  nerve regeneration  fractalkine  CX3 chemokine receptor 1  neuronal maturation  dendrites  doublecortin  synaptic maturation  newborn neurons  neural regeneration  nerve regeneration  neurodegenerative diseases  Alzheimer′s disease  transgenic animal models  mice  epimedium herb  milkvetch root  kudzuvine root  divalent metal transporter 1  ferroportin 1  neural regeneration  nerve regeneration  microRNA-124  neurogenesis  neuronal survival  Huntington′s disease  SRY-related HMG box transcription factor 9  brain-derived neurotrophic factor  peroxisome proliferator-activated receptor gamma coactivator 1-alpha  mutant huntingtin  nerve regeneration  Ras/Raf/Erk1/2 signaling pathway  spinal cord injury  apoptosis  repair  regulation  inhibition  neural regeneration  nerve regeneration  neurogenic bladder  bibliometric analysis  Web of Science database  visualization analysis  CiteSpace III  citation analysis  neural regeneration  nerve regeneration  sciatic nerve injury  autologous nerve grafting  epineurial suturing  three-dimensional finite element models  load  stress  displacement  neural regeneration  nerve regeneration  brain injury  facial palsy  Bell′s palsy  comparison  methodological quality  therapy  fixed effect model  acupuncture  incomplete recovery  randomized controlled trials  electroacupuncture  NSFC grants  neural regeneration  nerve regeneration  peripheral nerve injury  thalidomide  ankylosing spondylitis  adverse reactions  peripheral neuropathy  treatment  dose  treatment time  age  sex  neural regeneration  Neurology. Diseases of the nervous system  RC346-429  prospective study  
High-dose thalidomide increases the risk of peripheral neuropathy in the treatment of ankylosing spondylitis 期刊论文  OAI收割
Neural Regeneration Research, 2015, 卷号: 10, 期号: 5, 页码: 814-818
作者:  
Xue Hongxia;  Fu Wenyi;  Cui Huadong;  Yang Lili;  Zhang Ning
  |  收藏  |  浏览/下载:37/0  |  提交时间:2021/02/02
active zone stability  Drosophila  neuromuscular junction  dephosphorylation  Liprin-α  Syd-1  PP2A  GSK-3?  living scaffolds  neural tissue engineering  cell transplant  biomaterials  regeneration  neurotrauma  neurodegeneration  axon pathfinding  cell migration  injury  plasticity  neurodegenerative disease  brain  therapy  neuron  microglia  neural progenitor  tissue engineering  neuroregeneration  repair  central nervous system  biomaterial  regenerative medicine  nanotechnology  spinal cord injury  axonal regeneration  exosome  extracellular vesicle  microRNA  microvesicle  nerve gap  neurite outgrowth  peripheral nerve injury  Schwann cell  stem cell  hemodynamic phases  cerebral subarachnoid hemorrhage  metabolic crises  nerve regeneration  hypoxic-ischemic brain damage  ginsenoside Rg1  neural stem cells  cell transplantation  cell differentiation  cognition  nerve reconstruction  neural regeneration  nerve regeneration  brain injury  neuroimaging  functional magnetic resonance imaging  regional homogeneity  apoplexy  subacute  ischemia  participants  healthy  volunteers  brain activity  NSFC grants  neural regeneration  nerve regeneration  brain injury  neuroprotection  cerebral ischemia/reperfusion injury  lateral intracerebroventricular injection  Apelin-13  nerve apoptosis  Bcl-2  caspase-3  NSFC grants  neural regeneration  nerve regeneration  fractalkine  CX3 chemokine receptor 1  neuronal maturation  dendrites  doublecortin  synaptic maturation  newborn neurons  neural regeneration  nerve regeneration  neurodegenerative diseases  Alzheimer′s disease  transgenic animal models  mice  epimedium herb  milkvetch root  kudzuvine root  divalent metal transporter 1  ferroportin 1  neural regeneration  nerve regeneration  microRNA-124  neurogenesis  neuronal survival  Huntington′s disease  SRY-related HMG box transcription factor 9  brain-derived neurotrophic factor  peroxisome proliferator-activated receptor gamma coactivator 1-alpha  mutant huntingtin  nerve regeneration  Ras/Raf/Erk1/2 signaling pathway  spinal cord injury  apoptosis  repair  regulation  inhibition  neural regeneration  nerve regeneration  neurogenic bladder  bibliometric analysis  Web of Science database  visualization analysis  CiteSpace III  citation analysis  neural regeneration  nerve regeneration  sciatic nerve injury  autologous nerve grafting  epineurial suturing  three-dimensional finite element models  load  stress  displacement  neural regeneration  nerve regeneration  brain injury  facial palsy  Bell′s palsy  comparison  methodological quality  therapy  fixed effect model  acupuncture  incomplete recovery  randomized controlled trials  electroacupuncture  NSFC grants  neural regeneration  nerve regeneration  peripheral nerve injury  thalidomide  ankylosing spondylitis  adverse reactions  peripheral neuropathy  treatment  dose  treatment time  age  sex  neural regeneration  Neurology. Diseases of the nervous system  RC346-429  prospective study  
A Study of Three Linker Peptides' Cleavage Efficiency at The Post-translational Level 期刊论文  OAI收割
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2014, 卷号: 41, 期号: 6, 页码: 558-566
作者:  
Li, HY;  Zhou, ZM;  Pan, Q;  Yang, DM;  Gu, JF
收藏  |  浏览/下载:402/0  |  提交时间:2015/07/22
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文  OAI收割
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  
Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
收藏  |  浏览/下载:40/0  |  提交时间:2015/05/14
2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)  one of the major components isolated from the traditional  Chinese medicine Rubia yunnanensis  exhibited inhibitory activity on the proliferation of several  human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay  and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle  arrest in human cervical carcinoma HeLa cells. Further  MTA was found to induce apoptosis of HeLa cells  through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and  release of cytochrome c into the cytosol  which caused the cleavage of caspase and poly(ADP-ribose)  polymerase and finally triggered the apoptosis. Furthermore  the p53/p21/Cdc2-cyclin B1 signaling was  found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of  cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused  the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of  R. yunnanensis  a folk anti-cancer herb used in Yunnan  China.  
beta-D-Glucosyl-(1-4)-alpha-L-thevetosides of 17 beta-digitoxigenin from seeds of Cerbera manghas L. induces apoptosis in human hepatocellular carcinoma HepG2 cells 期刊论文  OAI收割
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 2012, 卷号: 64, 期号: 5, 页码: 403-410
作者:  
Feng, Bo;  Guo, Yue-Wei;  Huang, Cai-Guo;  Li, Liang;  Jiao, Bing-Hua
  |  收藏  |  浏览/下载:14/0  |  提交时间:2019/01/08