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浏览/检索结果: 共16条，第1-10条 帮助

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Downregulation of TET1 Promotes Bladder Cancer Cell Proliferation and Invasion by Reducing DNA Hydroxymethylation of AJAP1 期刊论文  OAI收割
FRONTIERS IN ONCOLOGY, 2020, 卷号: 10, 页码: 16
作者:  Yan, Yi-lin;  Huang, Zheng-nan;  Zhu, Zhen;  Cui, Yang-yan;  Li, Mei-qian
  |  收藏  |  浏览/下载：54/0  |  提交时间：2020/12/24
DNA去甲基化在树鼩脑发育和衰老过程中的动态变化 学位论文  OAI收割
北京: 中国科学院大学, 2017
作者:  魏姝
  |  收藏  |  浏览/下载：70/0  |  提交时间：2019/09/24
Elucidation of the Mechanism for the Substrate Preference of TET Proteins 期刊论文  OAI收割
Chinese Journal of Cell Biology, 2016, 卷号: 38, 期号: 1, 页码: 1-6
作者:  Lu Junyan;  Hu Lulu;  Cheng Jingdong;  Wang Chen;  Xu Yanhui
  |  收藏  |  浏览/下载：27/0  |  提交时间：2019/01/08
Facile One-Step Photochemical Fabrication and Characterization of an Ultrathin Gold-Decorated Single Glass Nanopipette 期刊论文  OAI收割
analytical chemistry, 2015, 卷号: 87, 期号: 6, 页码: 3216-3221
作者:  Xu,Xiaolong;  He,Haili;  Jin,Yongdong
收藏  |  浏览/下载：37/0  |  提交时间：2016/05/06
Spatial blockage of ionic current for electrophoretic translocation of DNA through a graphene nanopore 期刊论文  OAI收割
electrophoresis, 2014, 卷号: 35, 期号: 8, 页码: 1144-1151
作者:  Lv, Wenping;  Liu, Shengju;  Li, Xin;  Wu, Ren'an
收藏  |  浏览/下载：22/0  |  提交时间：2015/11/17
G-Quadruplex binding enantiomers show chiral selective interactions with human telomere 期刊论文  OAI收割
nucleic acids research, 2014, 卷号: 42, 期号: 6, 页码: 3792-3802
Wang, Jiasi; Chen, Yong; Ren, Jinsong; Zhao,Chuanqi; Qu,Xiaogang
收藏  |  浏览/下载：53/0  |  提交时间：2015/03/25
超高效液相色谱-串联质谱检测DNA修饰的方法发展及其应用研究 学位论文  OAI收割
博士, 北京: 中国科学院研究生院, 2013
尹瑞川
收藏  |  浏览/下载：110/0  |  提交时间：2014/07/14
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文  OAI收割
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
收藏  |  浏览/下载：42/0  |  提交时间：2015/05/14
2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)  one of the major components isolated from the traditional  Chinese medicine Rubia yunnanensis  exhibited inhibitory activity on the proliferation of several  human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay  and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle  arrest in human cervical carcinoma HeLa cells. Further  MTA was found to induce apoptosis of HeLa cells  through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and  release of cytochrome c into the cytosol  which caused the cleavage of caspase and poly(ADP-ribose)  polymerase and finally triggered the apoptosis. Furthermore  the p53/p21/Cdc2-cyclin B1 signaling was  found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of  cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused  the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of  R. yunnanensis  a folk anti-cancer herb used in Yunnan  China.  
Surface modification of graphene nanopores for protein translocation 期刊论文  OAI收割
nanotechnology, 2013, 卷号: 24, 期号: 49, 页码: 文献号：495102
Shan YP; Tiwari PB; Krishnakumar P; Vlassiouk I; Li WZ; Wang XW; Darici Y; Lindsay SM; Wang HD; Smirnov S; He J
收藏  |  浏览/下载：25/0  |  提交时间：2014/04/14
Cooperative translocation dynamics of biopolymer chains through nanopores in a membrane: Slow dynamics limit 期刊论文  OAI收割
European Physical Journal E, 2010, 卷号: 33, 期号: 3, 页码: 251-258
H. J. Wang; F. Gu; X. Z. Hong; X. W. Ba
收藏  |  浏览/下载：17/0  |  提交时间：2012/04/13