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	Heterozygous variants in USP25 cause genetic generalized epilepsy 期刊论文 OAI收割 BRAIN, 2024, 页码: 16 作者: Fan, Cui-Xia; Liu, Xiao-Rong; Mei, Dao-Qi; Li, Bing-Mei; Li, Wen-Bin \| 收藏 \| 浏览/下载：10/0 \| 提交时间：2024/10/09 genetic generalized epilepsy USP25 gain of function loss of function
	SCN8A epileptic encephalopathy mutations display a gain-of-function phenotype and divergent sensitivity to antiepileptic drugs 期刊论文 OAI收割 ACTA PHARMACOLOGICA SINICA, 2022, 页码: 10 作者: Guo, Qian-bei; Zhan, Li; Xu, Hai-yan; Gao, Zhao-bing; Zheng, Yue-ming \| 收藏 \| 浏览/下载：52/0 \| 提交时间：2022/08/30 early infantile epileptic encephalopathy type 13 SCN8A gain-of-function mutation antiepileptic drugs phenytoin carbamazepine
	Do Mutations Turn p53 into an Oncogene? 期刊论文 OAI收割 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 卷号: 20, 期号: 24, 页码: 6241 作者: Pitolli, Consuelo; Mancini, Mara; Melino, Gerry; Amelio, Ivano; Wang, Ying \| 收藏 \| 浏览/下载：11/0 \| 提交时间：2020/12/09 TP53 mutant TP53 gain of function oncogenic
	Application research of intelligent algorithm in electric-driven flight simulation turntable (EI CONFERENCE) 会议论文 OAI收割 ISECS International Colloquium on Computing, Communication, Control, and Management, CCCM 2008, August 3, 2008 - August 4, 2008, Guangzhou, China Xie M.-J.; Wang Z.-Q.; Wang L.-M. 收藏 \| 浏览/下载：38/0 \| 提交时间：2013/03/25 Application Research of Intelligent Algorithm in Electric-driven Flight Simulation Turntable is discussed in this paper. Fuzzy control is used to solve the problem of fast tracking and overshoot since its essence belongs to PD control In order to improve the performance of system in low speed a method named variance-gain adaptive algorithm is introduced in this paper. It defines the amplifier gain as a function whose independent variable is speed so the amplifier gain can automatically be adjusted with the change of speed. When the turntable runs at low speed it has a big amplifier gain a good rigidity and high tracking accuracy. When the turntable runs at high speed the method can control the amplifier gain and ensure the system dynamic performance. Design and implementation of these algorithms is introduced in detail. Experiment results show that the Flight Simulation Turntable has achieved the required performance through using fuzzy control algorithm and variance-gain adaptive algorithm. 2008 IEEE.
	The spectral feature analysis of semiconductor thin disk laser (EI CONFERENCE) 会议论文 OAI收割 Optoelectronic Materials and Devices II, November 2, 2007 - November 5, 2007, Wuhan, China 作者: Li J.; Wang L.-J.; Wang L.-J.; Ning Y.-Q.; Li J. 收藏 \| 浏览/下载：23/0 \| 提交时间：2013/03/25 The semiconductor thin disk laser is a new type of semiconductor laser. This work gives the basic operation function of semiconductor disk laser and analyses the heat effect by the experimentally measured photoluminescence spectrum of the laser chip at different pump power and different temperature. We can see that: with increasing pump power the thermal effects of the gain material becomes seriously and causes the saturation of carrier lifetime so the electron-hole pair created in the absorbtion layer have no enough time to rate to one of the wells and the non-radiative recombination happens in the barrier. When the thermal effects becomes stronger the chip will not lasing. This phenomenon is from the smaller energy offset between barrier and quantum well. We optimize the original structure design and experimental technology. A non-absorbing AlGaAs layer who is transparent to the pumping and laser wavelength is added to confine the carriers in the quantum wells. At the same time a DBR with double reflecting band is induced to improve the absorbing efficiency of the pumping light. The single QW is replaced by the three narrow QWs This three QWs structure can add the quantum state of QW increase the recombination probability of carriers in the QWs and reduce the heat effect. The chemical etch equipment is also improved to control the surface unevenness to be within 50 nm.
	Chip design of linear CCD drive pulse generator and control interface (EI CONFERENCE) 会议论文 OAI收割 2nd International Symposium on Advanced Optical Manufacturing and Testing Technologies - Advanced Optical Manufacturing and Testing Technologies, November 2, 2005 - November 5, 2005, Xian, China 作者: Sun H.; Wang Y.; Wang Y.; Wang Y.; Wang Y. 收藏 \| 浏览/下载：30/0 \| 提交时间：2013/03/25 CCD noises and their causes are analyzed. Methods to control these noises such as Correlated Double Sampling (CDS) filtering cooling clamping and calibration are proposed. To improve CCD sensor's performances the IC called Analog Front End (AFE) integration of CDS clamping Programmable Gain Amplifier (PGA) offset and ADC which can fulfill the CDS and analog-to-digital conversion is employed to process the output signal of CCD. Based on the noise control approaches the idea of chip design of linear CCD drive pulse generator and control interface is introduced. The chip designed is playing the role of (1) drive pulse generator for both CCD and AFE and (2) interface helping to analysis and transfer control command and status information between MCU controller and drive pulse generator or between global control unit in the chip and CCD/AFE. There are 6 function blocks in the chip designed such as clock generator for CCD and AFE MCU interface AFE serial interface output interface CCD antiblooming parameter register and global control logic unit. These functions are implemented in a CPLD chip Xilinx XC2C256-6-VQ100 with 20MHz pixel frequency and 16-bit high resolution. This chip with the AFE can eliminate CCD noise largely and improve the SNR of CCD camera. At last the design result is presented.
	A new method of image reconstruction with high resolution in X-ray coded aperture imaging (EI CONFERENCE) 会议论文 OAI收割 Laser-Generated, Synchrotron, and Other Laboratory X-Ray and EUV Sources, Optics, and Applications II, August 2, 2005 - August 4, 2005, San Diego, CA, United states 作者: Sun Y.; Sun Y. 收藏 \| 浏览/下载：22/0 \| 提交时间：2013/03/25 In the processing diagnosis of the inertia confinement fusion (ICF) the ring coded aperture imaging technique is applied in order to gain high space and time resolutions simultaneously. The key of acquiring high spatial resolution is how to obtain a point spread function of an imaging system. The common method is the firsthand projection method which is an approximate one. The x-ray diffraction effect is neglected in the method so the resolution of reconstructed image is decreased. We have derived the point spread function (PSF) of the ring coded aperture from scalar diffraction theory. And the Wiener filter is fabricated on the basis of the PSF. In National Key Laboratory of Laser Fusion at China Academy of Engineering Physics the imaging experiment on the diagnosis of ICF is completed using the ring coded aperture plate with inner diameter d1 = 250m and outer diameter d2 = 260m . The obtained coded image is processed by the Wiener filter which diffractive effect is considered. The processed results have shown that resolution and modulation contrast of acquired image are evidently better than the results obtained by the firsthand projection method.