中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [76]
大连化学物理研究所 [7]
中国科学院大学 [6]
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期刊论文 [116]
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DNA-Encoded Noncanonical Substrate Library for Protease Profiling
期刊论文
OAI收割
CHEMBIOCHEM, 2024, 页码: 12
作者:
  |  
收藏
  |  
浏览/下载:73/0
  |  
提交时间:2024/12/16
Protease substrate
DNA-encoded library
Combinatorial peptide library
High-throughput screening
Covalent inhibitor
Noncanonical peptide
Exploring the mechanism of contact-dependent cell-cell communication on chemosensitivity based on single-cell high-throughput drug screening platform
期刊论文
OAI收割
TALANTA, 2024, 卷号: 273, 页码: 8
作者:
Jiang, Yue
;
Ren, Xuelian
;
Liu, Guobin
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2024/05/31
Microfluidic chip
High-throughput drug screening
Quantitative proteomics
Contact-dependent cell-cell communication
Tumour single cells
Discovery of a novel OGT inhibitor through high-throughput screening based on Homogeneous Time-Resolved Fluorescence (HTRF)
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 139, 页码: 12
作者:
Wu, Xinyu
;
Wang, Mingchen
;
Cao, Yu
;
Xu, Ying
;
Yang, Ziqun
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/02/27
O-GlcNAcylation
O-GlcNAc transferase
High-throughput screening
Inhibitor
Thimerosal, a competitive thioredoxin reductase 1 (TrxR1) inhibitor discovered via high-throughput screening
期刊论文
OAI收割
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2023, 卷号: 650, 页码: 117-122
作者:
Ni, Yicheng
;
Luo, Zhongyuan
;
Lv, Yixin
;
Ma, Shuyuan
;
Luo, Cheng
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2023/10/17
Thioredoxin reductase 1 inhibitor
Chemical probe
High -throughput screening
Thimerosal
High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors
期刊论文
OAI收割
PROTEIN & CELL, 2023, 卷号: 14, 期号: 1, 页码: 17-27
作者:
Zang, Yi
;
Su, Mingbo
;
Wang, Qingxing
;
Cheng, Xi
;
Zhang, Wenru
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2024/03/27
high-throughput screening
SARS
CoV-2
main
papain-like
proteases
Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 10
作者:
Song, Jia
;
Yang, Rui-rui
;
Chang, Jie
;
Liu, Ya-dan
;
Lu, Cheng-hao
  |  
收藏
  |  
浏览/下载:66/0
  |  
提交时间:2022/11/11
cyclic GMP-AMP synthase
covalent inhibitor
inflammatory bowel disease
high-throughput screening
The discovery of a non-competitive GOT1 inhibitor, hydralazine hydrochloride, via a coupling reaction-based high-throughput screening assay
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2022, 卷号: 73, 页码: 6
作者:
Wu, Qiqi
;
Sun, Zhongya
;
Chen, Zhifeng
;
Liu, Jingqiu
;
Ding, Hong
  |  
收藏
  |  
浏览/下载:72/0
  |  
提交时间:2022/08/30
Glutamate oxaloacetate transaminase 1
Inhibitor
Hydralazine hydrochloride
High -throughput screening
Recent progress in assays for GPCR drug discovery
期刊论文
OAI收割
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2022, 卷号: 323, 期号: 2, 页码: C583-C594
作者:
Guo, Shimeng
;
Zhao, Tingting
;
Yun, Ying
;
Xie, Xin
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收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/04/10
biased signaling
GPCR
high -throughput screening assays
humanized mouse model
protein
protein interaction
Genome-wide high-throughput signal peptide screening via plasmid pUC256E improves protease secretion in Lactiplantibacillus plantarum and Pediococcus acidilactici
期刊论文
OAI收割
BMC GENOMICS, 2022, 卷号: 23, 期号: _, 页码: -
作者:
Chen, Binbin
;
Loo, Bryan Zong Lin
;
Cheng, Ying Ying
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2022/04/25
Signal peptide
Protease secretion
High-throughput screening
Genetic engineering
Lactiplantibacillus plantarum
Pediococcus acidilactici
Machine Learning-Based Models with High Accuracy and Broad Applicability Domains for Screening PMT/vPvM Substances
期刊论文
OAI收割
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2022, 卷号: 56, 期号: 24, 页码: 1-10
作者:
Zhao, Qiming
;
Yu, Yang
;
Gao, Yuchen
;
Shen, Lilai
;
Cui, Shixuan
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2023/02/06
PMT/vPvM substances
high-throughput screening
machine learning
hazard classification
risk management