中国科学院机构知识库网格系统: 检索

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	Combining mutagenesis on Glu281 of prenyltransferase NovQ and metabolic engineering strategies for the increased prenylated activity towards menadione 期刊论文 OAI收割 APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2020 作者: Ni, Wenfeng; Zheng, Zhiming; Liu, Hui; Wang, Peng; Wang, Han \| 收藏 \| 浏览/下载：44/0 \| 提交时间：2020/11/26 Prenyltransferase NovQ Menadione hydroquinol Site-directed mutagenesis Mevalonate pathway Metabolic engineering
	Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states 期刊论文 OAI收割 JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 卷号: 294, 期号: 3, 页码: 953-967 作者: Yan, Yan; Zhou, X. Edward; Novick, Scott J.; Shaw, Simon J.; Li, Yingwu \| 收藏 \| 浏览/下载：23/0 \| 提交时间：2020/07/01 AMP-activated kinase (AMPK) AMP hydrogen exchange mass spectrometry X-ray crystallography phosphorylation activation loop phosphorylation ADaM site CBS3 R734 R739 metabolic disorder energy sensor
	Conformational heterogeneity of the allosteric drug and metabolite (ADaM) site in AMP-activated protein kinase (AMPK) 期刊论文 OAI收割 JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 44, 页码: 16994-17007 作者: Gu, Xin; Bridges, Michael D.; Yan, Yan; de Waal, Parker W.; Zhou, X. Edward \| 收藏 \| 浏览/下载：75/0 \| 提交时间：2019/01/08 AMP-activated kinase (AMPK) biophysics diabetes metabolic regulation cancer ADaM site DEER
	Systematic engineering of pentose phosphate pathway improves Escherichia coli succinate production 期刊论文 OAI收割 BIOTECHNOLOGY FOR BIOFUELS, 2016, 卷号: 9, 期号: 11 作者: Tan, Zaigao; Chen, Jing; Zhang, Xueli 收藏 \| 浏览/下载：37/0 \| 提交时间：2017/03/13 Escherichia coli Pentose phosphate pathway (PPP) Succinate Reducing equivalent Ribosome binding site library (RBSL) Multivariate modular metabolic engineering (MMME)
	Evaluation of the sludge reduction effectiveness of a metabolic uncoupler-tetrakis (hydroxymethyl) phosphonium sulfate in anaerobic/anoxic/oxic process 期刊论文 OAI收割 DESALINATION AND WATER TREATMENT, 2016, 卷号: 57, 期号: 13, 页码: 5772-5780 作者: Xiao, Benyi; Li, Hechao; Yan, Hong; Guo, Xuesong \| 收藏 \| 浏览/下载：24/0 \| 提交时间：2017/03/29 Adding Site Anaerobic-anoxic-oxic Process Metabolic Uncoupler Sludge Reduction Thps
	A Mechanism-Based Model for the Prediction of the Metabolic Sites of Steroids Mediated by Cytochrome P450 3A4 期刊论文 OAI收割 international journal of molecular sciences, 2015, 卷号: 16, 期号: 7, 页码: 14677-14694 作者: Dai, Zi-Ru; Ai, Chun-Zhi; Ge, Guang-Bo; He, Yu-Qi; Wu, Jing-Jing 收藏 \| 浏览/下载：30/0 \| 提交时间：2015/11/17 CYP3A4 steroids metabolic site mechanism-based prediction activation energy
	Lead compound optimization strategy (1)changing metabolic pathways and optimizing metabolism stability 期刊论文 OAI收割 Acta Pharmaceutica Sinica, 2013, 卷号: 48, 期号: 10, 页码: 1521-1531 作者: Wang Jiang; Liu Hong \| 收藏 \| 浏览/下载：14/0 \| 提交时间：2019/01/08 metabolism stability lead compound block metabolic site lipophilicity half life