中国科学院机构知识库网格系统: 检索

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	Structural and mechanistic insights provided by single particle cryo-EM analysis of phosphoinositide 3-kinase (PI3Ka) 期刊论文 OAI收割 BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2023, 卷号: 1878, 期号: 5, 页码: 6 作者: Vogt, Peter K.; Hart, Jonathan R.; Yang, Su; Zhou, Qingtong; Yang, Dehua \| 收藏 \| 浏览/下载：23/0 \| 提交时间：2023/10/17 Phosphoinositide 3-kinase BYL-719 Nanobody CXMS Mutants
	Structural insights into the interaction of three Y- shaped ligands with PI3Kα 期刊论文 OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 34, 页码: 9 作者: Zhou, Qingtong; Liu, Xiao; Neri, Dario; Li, Wenxin; Favalli, Nicholas \| 收藏 \| 浏览/下载：26/0 \| 提交时间：2023/12/08 phosphoinositide 3-kinase drug target ligand binding pocket chemical scaffold
	Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3K alpha 期刊论文 OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 卷号: 119, 期号: 46, 页码: 11 作者: Liu, Xiao; Zhou, Qingtong; Hart, Jonathan R.; Xu, Yingna; Yang, Su \| 收藏 \| 浏览/下载：28/0 \| 提交时间：2023/10/17 phosphoinositide 3-kinase (PI3K) mass spectrometry mutants
	Nanobodies and chemical cross-links advance the structural and functional analysis of PI3K alpha 期刊论文 OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 卷号: 119, 期号: 38, 页码: 9 作者: Hart, Jonathan R.; Liu, Xiao; Pan, Chen; Liang, Anyi; Ueno, Lynn \| 收藏 \| 浏览/下载：24/0 \| 提交时间：2023/10/17 phosphoinositide 3-kinase (PI3K) nanobody conformational changes chemical cross-linking mass spectrometry
	Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation 期刊论文 OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 45, 页码: 9 作者: Liu, Xiao; Yang, Su; Hart, Jonathan R.; Xu, Yingna; Zou, Xinyu \| 收藏 \| 浏览/下载：67/0 \| 提交时间：2022/01/04 phosphoinositide 3-kinase (PI3K) activation inhibition activity-dependent conformational changes
	Emerging roles of class I PI3K inhibitors in modulating tumor microenvironment and immunity 期刊论文 OAI收割 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 8 作者: Sun, Pu; Meng, Ling-hua \| 收藏 \| 浏览/下载：33/0 \| 提交时间：2020/12/21 phosphoinositide 3-kinase (PI3K) PI3K inhibitors tumor microenvironment immune cells immunotherapy
	BOS-93, a novel bromophenol derivative, induces apoptosis and autophagy in human A549 lung cancer cells via PI3K/Akt/mTOR and MAPK signaling pathway 期刊论文 OAI收割 EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2019, 卷号: 17, 期号: 5, 页码: 3848-3858 作者: Guo, Chuanlong; Wang, Lijun; Zhao, Yue; Jiang, Bo; Luo, Jiao \| 收藏 \| 浏览/下载：134/0 \| 提交时间：2019/08/28 bromophenol apoptosis autophagy phosphoinositide 3-kinase protein kinase B mechanistic target of rapamycin signaling reactive oxygen species
	The crossregulation between ERK and PI3K signaling pathways determines the tumoricidal efficacy of MEK inhibitor 期刊论文 OAI收割 JOURNAL OF MOLECULAR CELL BIOLOGY, 2012, 卷号: 4 - \| 收藏 \| 浏览/下载：25/0 \| 提交时间：2020/10/26 KINASE KINASE-1/2 INHIBITOR PHOSPHOINOSITIDE 3-KINASE-GAMMA ADVANCED CANCERS LUNG-CANCER CELL LUNG PHASE-II RESISTANCE ROBUSTNESS ACTIVATION MUTATIONS systems biology mathematical model ERK pathway PI3K pathway MEK inhibitor resistance robustness biochemical control analysis
	Measurement of binding kinetics between PI3-K and phosphorylated IGF-1R using a surface plasmon resonance biosensor 期刊论文 OAI收割 MICROCHIMICA ACTA, 2008, 卷号: 162, 期号: 1-2, 页码: 253-260 Li, XL; Fong, CC; Huang, MH; Cao, HM; Zhao, JL; Yang, MS 收藏 \| 浏览/下载：16/0 \| 提交时间：2011/12/17 GROWTH-FACTOR-I PHOSPHATIDYLINOSITOL 3-KINASE SIGNAL-TRANSDUCTION INSULIN-RECEPTOR 2-HYBRID SYSTEM PHOSPHOINOSITIDE 3-KINASES TYROSINE KINASE PROTEIN-KINASES SH2 DOMAINS SUBUNIT