中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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长春应用化学研究所 [14]
上海应用物理研究所 [6]
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期刊论文 [59]
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Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson's disease treatment
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 卷号: 44, 期号: 6, 页码: 1122-1134
作者:
Wang, Qing
;
Yao, Sheng
;
Yang, Ze-xian
;
Zhou, Chen
;
Zhang, Yu
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2024/03/27
Parkinson's disease
alpha-synuclein aggregation
protein-protein interaction
03A10
MPTP/p model
enema inoculation model
Pyropia haitanensis polysaccharide extends lifespan by inhibiting protein aggregation in Caenorhabditis elegans
CNKI期刊论文
OAI收割
2021
作者:
Zhongshan ZHANG
;
Xiaomei WANG
;
Yongliang PAN
;
Zhanqi WANG
;
Zhengshun WEN
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/12/18
Pyropia haitanensis
polysaccharide
protein aggregation
Caenorhabditis elegans
Multiscale computational prediction of beta-sheet peptide self-assembly morphology
期刊论文
OAI收割
MOLECULAR SIMULATION, 2020
作者:
Deng, Li
;
Wang, Yanting
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/06/16
MOLECULAR-DYNAMICS METHOD
INTERMOLECULAR FORCES
PROTEIN AGGREGATION
NANOMECHANICS
POLYMORPHISM
SIMULATIONS
TRANSITIONS
NANOTUBES
FIBRILS
SOLVENT
Peptides Co-Assembling into Hydrangea-Like Microstructures
期刊论文
OAI收割
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2020, 卷号: 20, 期号: 5, 页码: 3239-3245
作者:
Guo, Z
;
Shen, ZW
;
Wang, YJ
;
Tan, TY
;
Zhang, Y
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2021/09/06
PROTEIN SECONDARY STRUCTURE
NEURODEGENERATIVE DISEASES
AMYLOID HYPOTHESIS
ALZHEIMERS-DISEASE
DESIGN
FIBERS
SPECTROSCOPY
AGGREGATION
FIBRILS
INSULIN
Prion dimer is heterogenous and is modulated by multiple negative and positive motifs
期刊论文
iSwitch采集
Biochemical and biophysical research communications, 2019, 卷号: 509, 期号: 2, 页码: 570-576
作者:
Gao, Zhenxing
;
Shi, Jing
;
Cai, Lili
;
Luo, Minhua
;
Wong, Boon-Seng
收藏
  |  
浏览/下载:86/0
  |  
提交时间:2019/05/08
Prion protein
Disulfide bond
Fatal familial insomnia
Prp dimer
Prp aggregation
The Hydration Shell of Monomeric and Dimeric Insulin Studied by Terahertz Time-Domain Spectroscopy
期刊论文
OAI收割
BIOPHYSICAL JOURNAL, 2019, 卷号: 117, 期号: 3, 页码: 533-541
作者:
Wang, PF
;
Wang, XC
;
Liu, LY
;
Zhao, HW
;
Qi, W
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/10/16
WATER DYNAMICS
PROTEIN AGGREGATION
DISSOCIATION
FIBRILS
MOLECULES
DIFFUSION
RESONANCE
BINDING
NMR
Protein Aggregation and Performance Optimization Based on Microconformational Changes of Aromatic Hydrophobic Regions
期刊论文
OAI收割
MOLECULAR PHARMACEUTICS, 2018, 卷号: 15, 期号: 6, 页码: 2257-2267
作者:
Wen, Lili
;
Lyu, Man
;
Xiao, Huashuai
;
Lan, Hairong
;
Zuo, Zhili
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2018/07/16
Protein Aggregation
Aromatic Hydrophobic Regions
Amine Compounds
Guanidine Compounds
Microconformational Change
Engineering of Fc Fragments with Optimized Physicochemical Properties Implying Improvement of Clinical Potentials for Fc-Based Therapeutics
期刊论文
OAI收割
FRONTIERS IN IMMUNOLOGY, 2018, 卷号: 8, 页码: 14
作者:
Yang, Chunpeng
;
Gao, Xinyu
;
Gong, Rui
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2018/12/29
monoclonal antibody
Fc-fusion protein
Fc-based therapeutics
optimization
physicochemical property
stability
aggregation
Effects of nanobubbles on peptide self-assembly
期刊论文
OAI收割
NANOSCALE, 2018, 卷号: 10, 期号: 42, 页码: 20007-20012
作者:
Wang, YJ
;
Shen, ZW
;
Guo, Z
;
Hu, J
;
Zhang, Y
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/12/17
AIR-WATER-INTERFACE
NEURODEGENERATIVE DISEASES
PROTEIN AGGREGATION
AMYLOID FIBRILS
BETA(2)-MICROGLOBULIN
MECHANISM
SURFACES
BIOLOGY
FIBERS
GROWTH