中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页
机构
成果
学者
登录
注册
登陆
×
验证码:
换一张
忘记密码?
记住我
×
校外用户登录
CAS IR Grid
机构
上海药物研究所 [84]
昆明植物研究所 [17]
昆明动物研究所 [6]
金属研究所 [5]
化学研究所 [2]
烟台海岸带研究所 [2]
更多
采集方式
OAI收割 [127]
内容类型
期刊论文 [126]
学位论文 [1]
发表日期
2013 [127]
学科主题
Pharmacolo... [6]
Chemistry,... [4]
Multidisci... [4]
Biochemist... [3]
Chemistry [2]
Biotechnol... [1]
更多
筛选
浏览/检索结果:
共127条,第1-10条
帮助
限定条件
发表日期:2013
条数/页:
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
排序方式:
请选择
题名升序
题名降序
提交时间升序
提交时间降序
作者升序
作者降序
发表日期升序
发表日期降序
Inhibition of Human Neutrophil Elastase by Pentacyclic Triterpenes
期刊论文
OAI收割
PLOS ONE, 2013, 卷号: 8, 期号: 12
作者:
Feng, Li
;
Liu, Xiaoyu
;
Zhu, Weiliang
;
Guo, Fujiang
;
Wu, Yingchun
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Design, synthesis and biological evaluation of novel 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of the epidermal growth factor receptor
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 卷号: 21, 期号: 24, 页码: 7988-7998
作者:
Zhang, Xu
;
Peng, Ting
;
Ji, Xun
;
Li, Jian
;
Tong, Linjiang
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/01/08
EGFR inhibitor
EGFR T790M/L858R
Binding mode
Irreversible EGFR inhibitor
Combinatorial Pharmacophore Modeling of Organic Cation Transporter 2 (OCT2) Inhibitors: Insights into Multiple Inhibitory Mechanisms
期刊论文
OAI收割
MOLECULAR PHARMACEUTICS, 2013, 卷号: 10, 期号: 12, 页码: 4611-4619
作者:
Xu, Yuan
;
Liu, Xian
;
Li, Shanshan
;
Zhou, Nannan
;
Gong, Likun
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
organic cation transporter 2 (OCT2)
drug clearance
drug-drug interaction (DDI)
pharmacophore
multiple inhibition mechanism
Synthesis and characterization of 5,7-dihydroxyflavanone derivatives as novel protein tyrosine phosphatase 1B inhibitors
期刊论文
OAI收割
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2013, 卷号: 28, 期号: 6, 页码: 1199-1204
作者:
Sun, Liang-Peng
;
Ma, Wei-Ping
;
Gao, Li-Xin
;
Yang, Ling-Ling
;
Quan, Ying-Chun
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
Protein tyrosine phosphatase 1B
inhibitors
5,7-dihydroxyflavanone
structure-activity relationship
diabetes
De Novo Design, Synthesis and Evaluation of Benzylpiperazine Derivatives as Highly Selective Binders of Mcl-1
期刊论文
OAI收割
CHEMMEDCHEM, 2013, 卷号: 8, 期号: 12, 页码: 1986-2014
作者:
Ding, Xiao
;
Li, Yan
;
Lv, Li
;
Zhou, Mi
;
Han, Li
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
apoptosis
bcl-2 family proteins
protein-protein interactions
selective inhibitors
Synthesis and biological evaluation of pyrrolidine-2-carbonitrile and 4-fluoropyrrolidine-2-carbonitrile derivatives as dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 卷号: 21, 期号: 23, 页码: 7418-7429
作者:
Wang, Jiang
;
Feng, Ying
;
Ji, Xun
;
Deng, Guanghui
;
Leng, Ying
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
Pyrrolidine-2-carbonitrile
4-Fluoropyrrolidine-2-carbonitrile
Dipeptidyl peptidase-4 inhibitor
Oral glucose tolerance test
Type 2 diabetes
The discovery and optimization of novel dual inhibitors of topoisomerase ii and histone deacetylase
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 卷号: 21, 期号: 22, 页码: 6981-6995
作者:
Zhang, Xuan
;
Bao, Bin
;
Yu, Xiuhua
;
Tong, Linjiang
;
Luo, Yu
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Podophyllotoxin
HDAC
Topoisomerase II
Cancer
Hybrid
Synergistic effect
化合物DB-02和SJP-L-5体外抗HIV-1活性及耐药性机制研究
学位论文
OAI收割
博士, 北京: 中国科学院研究生院, 2013
作者:
张兴杰
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2014/02/11
DB-02
S-DABO
S-DACO
耐药性
HIV-1
SJP-L-5
木脂素
非核苷类
逆转录酶抑制剂
五味子科
Design, synthesis, and biological evaluation of novel 2-ethyl-5-phenylthiazole-4-carboxamide derivatives as protein tyrosine phosphatase 1B inhibitors with improved cellular efficacy
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 69, 页码: 399-412
作者:
Chen, Yue-Ting
;
Tang, Chun-Lan
;
Ma, Wei-Ping
;
Gao, Li-Xin
;
Wei, Yi
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/01/08
Protein tyrosine phosphatase 1B
Type 2 diabetes
2-Ethyl-5-phenylthiazole-4-carboxamide (PTA)
SAR
Identification of Novel Small Molecules as Inhibitors of Hepatitis C Virus by Structure-Based Virtual Screening
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2013, 卷号: 14, 期号: 11, 页码: 22845-22856
作者:
Li, Jing
;
Liu, Xian
;
Li, Shanshan
;
Wang, Yulan
;
Zhou, Nannan
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
hepatitis C virus (HCV)
NS3
NS4A serine protease
structure-based drug design (SBDD)
virtual screening