中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [115]
昆明植物研究所 [8]
过程工程研究所 [6]
武汉植物园 [6]
合肥物质科学研究院 [5]
海洋研究所 [4]
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OAI收割 [168]
内容类型
期刊论文 [168]
发表日期
2018 [168]
学科主题
Chemistry [1]
Electroche... [1]
Pharmacolo... [1]
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分析化学与药物化学 [1]
植物化学生态研究 [1]
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发表日期:2018
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Design and Synthesis of Marine Phidianidine Derivatives as Potential Immunosuppressive Agents
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 24, 页码: 11298-11308
作者:
Liu, Jin
;
Li, Heng
;
Chen, Kai-Xian
;
Zuo, Jian-Ping
;
Guo, Yue-Wei
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/07/01
Sulfuretin protects hepatic cells through regulation of ROS levels and autophagic flux
期刊论文
OAI收割
Acta pharmacologica Sinica, 2018
作者:
Lu, Yu-Ting
;
Xiao, Yu-Feng
;
Li, Yu-Feng
;
Li, Jia
;
Nan, Fa-Jun
  |  
收藏
  |  
浏览/下载:82/0
  |  
提交时间:2019/01/08
Discovery and structure-activity-relationship study of novel imidazole cyclopropyl amine analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3808-3812
作者:
Zheng, Qiangang
;
Chen, Ziqi
;
Wan, Huixin
;
Tang, Shuai
;
Ye, Yan
  |  
收藏
  |  
浏览/下载:234/0
  |  
提交时间:2019/01/08
IDH1 inhibitor
Imidazole cyclopropyl amine
Structure-based rational design
Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3693-3699
作者:
Zhu, Kongkai
;
Song, Jia-Li
;
Tao, Hong-Rui
;
Cheng, Zhi-Qiang
;
Jiang, Cheng-Shi
  |  
收藏
  |  
浏览/下载:100/0
  |  
提交时间:2019/01/08
Pharmacophore combination
Isoquinoline
PRMT5 inhibitor
Molecular docking
Molecular dynamics simulation
The secretome engages STAT3 to favor a cytokine-rich microenvironment in mediating acquired resistance to FGFR inhibitors
期刊论文
OAI收割
Molecular cancer therapeutics, 2018, 卷号: 145, 页码: 817-842
作者:
Wang, Xinyi
;
Ai, Jing
;
Liu, Hongyan
;
Peng, Xia
;
Chen, Hui
  |  
收藏
  |  
浏览/下载:135/0
  |  
提交时间:2019/01/08
1,4-Diaryl-2-azetidinone
Combretastatin A-4
Tubulin polymerization
Antitumor
Eucalypglobulusals A-J, Formyl-Phloroglucinol-Terpene Meroterpenoids from Eucalyptus globulus Fruits
期刊论文
OAI收割
JOURNAL OF NATURAL PRODUCTS, 2018, 卷号: 81, 期号: 12, 页码: 2638-2646
作者:
Qin, Xu-Jie
;
Jin, Ling-Yu
;
Yu, Qian
;
Liu, Hui
;
Khan, Afsar
  |  
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2019/03/18
Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2018, 卷号: 81, 页码: 289-298
作者:
Zhu, Kongkai
;
Tao, Hongrui
;
Song, Jia-Li
;
Jin, Lu
;
Zhang, Yuanyuan
  |  
收藏
  |  
浏览/下载:129/0
  |  
提交时间:2019/01/08
PRMT5 inhibitor
Arginine methylation
Virtual screening
Molecular docking
Molecular dynamics simulation
Exploring molecular mechanism of allosteric inhibitor to relieve drug resistance of multiple mutations in HIV-1 protease by enhanced conformational sampling
期刊论文
OAI收割
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2018, 卷号: 86, 期号: 12, 页码: 1294-1305
作者:
Chen, Jianzhong
;
Peng, Cheng
;
Wang, Jinan
;
Zhu, Weiliang
  |  
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2019/01/08
allosteric inhibitor
HIV-1 protease
MM-GBSA
normal mode analysis
REMD
Reduced graphene oxide-based bortezomib delivery system for photothermal chemotherapy with enhanced therapeutic efficacy
期刊论文
OAI收割
POLYMER INTERNATIONAL, 2018, 卷号: 67, 期号: 12, 页码: 1648-1654
作者:
Chen, Li
;
Ma, Weiqian
;
He, Liang
;
Hu, Yanfang
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/08/21
reduced graphene oxide (rGO)
non-covalent methods
bortezomib (BTZ) delivery
photothermal chemotherapy
Discovery of beta(2)-adrenoceptor agonists in Curcuma zedoaria Rosc using label-free cell phenotypic assay combined with two-dimensional liquid chromatography
期刊论文
OAI收割
JOURNAL OF CHROMATOGRAPHY A, 2018, 卷号: 1577, 页码: 59-65
作者:
Liu, Yanfang
;
Liang, Xinmiao
;
Zhou, Weijia
;
Wang, Jixia
;
Zhao, Yaopeng
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2019/06/20
Curcuma zedoaria Rosc
beta(2)-adrenoceptor agonists
Diarylheptanoids
Label-free cell phenotypic assay
Two-dimensional liquid chromatography