中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [185]
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OAI收割 [185]
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期刊论文 [177]
会议论文 [7]
专利 [1]
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2023 [9]
2022 [16]
2021 [14]
2020 [13]
2019 [18]
2018 [13]
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专题:上海药物研究所
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Discovery of a PROTAC degrader for METTL3-METTL14 complex
期刊论文
OAI收割
CELL CHEMICAL BIOLOGY, 2024, 卷号: 31, 期号: 1, 页码: 25
作者:
Du, Wenhao
;
Huang, Yuting
;
Chen, Xiaoai
;
Deng, Yue
;
Sun, Yaoliang
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/05/07
Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4748-4764
作者:
Liu, Yingqiang
;
Zhan, Zhengsheng
;
Kang, Zhuang
;
Li, Mengyuan
;
Lv, Yongcong
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/01/26
Small molecule inhibitor
Tumor microenvironment
Immune-checkpoint
immune-deficient mouse models
including temozolomide (TMZ) insensitive tumors. Notably
Identification of [1,2,4]Triazolo[4,3-a]pyrazine PARP1 inhibitors with overcome acquired resistance activities
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 259, 页码: 19
作者:
Wang, Pingyuan
;
Zhu, Wen-Ting
;
Wang, Yajing
;
Song, Shan-Shan
;
Xi, Yong
  |  
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2023/10/17
PARP1 inhibitor
Synthetic lethality
Drug resistance
Anticancer
Structure -activity relationship
Pharmaco-proteogenomic characterization of liver cancer organoids for precision oncology
期刊论文
OAI收割
SCIENCE TRANSLATIONAL MEDICINE, 2023, 卷号: 15, 期号: 706, 页码: 15
作者:
Ji, Shuyi
;
Feng, Li
;
Fu, Zile
;
Wu, Gaohua
;
Wu, Yingcheng
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/10/17
Effect of an Herbal-Based Injection on 28-Day Mortality in Patients With Sepsis The EXIT-SEP Randomized Clinical Trial
期刊论文
OAI收割
JAMA INTERNAL MEDICINE, 2023, 卷号: 183, 期号: 7, 页码: 647-655
作者:
Liu, Songqiao
;
Yao, Chen
;
Xie, Jianfeng
;
Liu, Hong
;
Wang, Hongliang
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/03/27
Scalarane sesterterpenes from the South China Sea sponge Hyrtios erecta and their PTP1B inhibitory activity
期刊论文
OAI收割
TETRAHEDRON, 2023, 卷号: 137, 页码: 5
作者:
Sun, Li-Li
;
Shen, Yi-Ran
;
Li, Jia
;
Wang, Jian-Rong
;
Li, Xu-Wen
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2023/10/17
Sponge
Hyrtios erecta
Scalarane-type sesterterpene
Configuration
PTP1B
Rh-Catalyzed C-H Activation/Annulation of Enaminones and Cyclic 1,3-Dicarbonyl Compounds: An Access to Isocoumarins
期刊论文
OAI收割
JOURNAL OF ORGANIC CHEMISTRY, 2023, 卷号: 88, 期号: 9, 页码: 5348-5358
作者:
Wang, Qian
;
Li, Ying
;
Sun, Jina
;
Chen, Shiyu
;
Li, Hui
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/03/27
Improved 2α-Hydroxylation Efficiency of Steroids by CYP154C2 Using Structure-Guided Rational Design
期刊论文
OAI收割
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2023, 卷号: 89, 期号: 3
作者:
Gao, Qilin
;
Ma, Bingbing
;
Wang, Qianwen
;
Zhang, Hao
;
Fushinobu, Shinya
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/03/27
P450
testosterone
androstenedione
crystal structure
rational design
Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance
期刊论文
OAI收割
EMBO MOLECULAR MEDICINE, 2023, 页码: 24
作者:
Wang, Li-Min
;
Wang, Pingyuan
;
Chen, Xiao-Min
;
Yang, Hui
;
Song, Shan-Shan
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/04/10
homologous recombination repair
olaparib-resistant
PARP inhibitor
PARP7
type I interferons
Design, synthesis and biological evaluation of KRASG12C-PROTACs
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 78, 页码: 14
作者:
Zhang, Xiaoyi
;
Zhao, Tong
;
Sun, Minghao
;
Li, Pei
;
Lai, Mengzhen
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2023/04/10
KRASG12C
PROTAC
Covalent inhibitors
Structure-activity relationships (SARs)
Anticancer