中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [19]
采集方式
OAI收割 [19]
内容类型
期刊论文 [19]
发表日期
2023 [3]
2022 [2]
2021 [1]
2020 [1]
2019 [2]
2017 [1]
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浏览/检索结果:
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专题:上海药物研究所
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Design and synthesis of 1H-pyrazolo[3,4-
d
]pyrimidine derivatives as hematopoietic progenitor kinase 1 (HPK1) inhibitors
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 140, 页码: 18
作者:
Zhang, Junjie
;
Li, Yan
;
Tang, Haotian
;
Zhou, Qianqian
;
Tong, Linjiang
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2023/12/08
Cancer immunotherapy
HPK1
Structure -based design
HPK1 inhibitor
Conformational Dynamics of the D53-D3-D14 Complex in Strigolactone Signaling
期刊论文
OAI收割
PLANT AND CELL PHYSIOLOGY, 2023, 页码: 11
作者:
Liu, Simiao
;
Wang, Jia
;
Song, Bin
;
Gong, Xinqi
;
Liu, Huihui
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2023/10/17
D3
D14
D53
Receptor complex
Signal transduction
Strigolactone
Modular Biomimetic Strategy Enabled Discovery of Simplified Pseudo-Natural Macrocyclic P-Glycoprotein Inhibitors Capable of Overcoming Multidrug Resistance
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 4, 页码: 2550-2565
作者:
Liu, Bo
;
Yu, Xueni
;
Liu, Liping
;
Wang, Lei
;
Wang, Jie
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/03/27
Hiding Payload Inside the IgG Fc Cavity Significantly Enhances the Therapeutic Index of Antibody-Drug Conjugates
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 16
作者:
Shi, Wei
;
Zhang, Jianxin
;
Liu, Liya
;
Li, Wanzhen
;
Liu, Zhi
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2023/04/10
SH2 Domain-Containing Phosphatase 2 Inhibition Attenuates Osteoarthritis by Maintaining Homeostasis of Cartilage Metabolism via the Docking Protein 1/Uridine Phosphorylase 1/Uridine Cascade
期刊论文
OAI收割
ARTHRITIS & RHEUMATOLOGY, 2022, 页码: 12
作者:
Liu, Qianqian
;
Zhai, Linhui
;
Han, Mingrui
;
Shi, Dongquan
;
Sun, Ziying
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/06/15
Systematic investigation on the anti-rheumatoid arthritis material basis and mechanism of Juan Bi Tang. Part 1: Integrating metabolic profiles and network pharmacology
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 202, 页码: 11
作者:
Li, Jiajia
;
Li, Lei
;
Wang, Yangyang
;
Zhao, Yuxuan
;
Hu, Pei
  |  
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2021/08/17
Juanbi-Tang (JBT)
Rheumatoid arthritis (RA)
Metabolites
Mass
Network pharmacology
Molecular docking
Alleviation of Synovial Inflammation of Juanbi-Tang on Collagen-Induced Arthritis and TNF-Tg Mice Model
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2020, 卷号: 11, 页码: 17
作者:
Wang, Tengteng
;
Jia, Qingyun
;
Chen, Tao
;
Yin, Hao
;
Tian, Xiaoting
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/07/01
Juanbi-Tang
rheumatoid arthritis
collagen-induced arthritis
synoviocyte
tumor necrosis factor
Structural insights into a novel Ca2+-independent PL-6 alginate lyase from Vibrio OU02 identify the possible subsites responsible for product distribution
期刊论文
OAI收割
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2019, 卷号: 1863, 期号: 7, 页码: 1167-1176
作者:
Lyu, Qianqian
;
Zhang, Keke
;
Shi, Yanhong
;
Li, Weihua
;
Diao, Xiaotong
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/07/01
Alginate lyase
PL-6
Catalytic mechanism
X-ray crystallography
Product distribution
Synthesis and biological evaluation of paclitaxel and vorinostat co-prodrugs for overcoming drug resistance in cancer therapy in vitro
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 7, 页码: 1405-1413
作者:
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
PTX
SAHA
Co-prodrug
Nanomicelles
Differential function analysis: identifying structure and activation variations in dysregulated pathways
期刊论文
OAI收割
Science China. Information Science, 2017, 卷号: 60, 期号: 1
作者:
Chen Luonan
;
Zeng Tao
;
Shi Qianqian
;
Zhang Chuanchao
;
Liu Juan
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2020/07/01
NONNEGATIVE MATRIX FACTORIZATION
EARLY-WARNING SIGNALS
COMPLEX DISEASES
MICROARRAY DATA
GASTRIC-CANCER
MODULE NETWORK
PREDICTION
DISCOVERY
ONTOLOGY
NOISE
complex disease
biological function
non-negative matrix factorization
network structure
function activation