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浏览/检索结果: 共113条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers 期刊论文  OAI收割 CANCER LETTERS, 2024, 卷号: 582, 页码: 15 作者:  Lu, Xuxiu;  Yu, Rilei;  Li, Zhen;  Yang, Mengke;  Dai, Jiajia   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/04/07 Acquired resistance  Cancer  NSCLC  JC-010a  SHP2   Structure-based development of potent and selective type-II kinase inhibitors of RIPK1 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 1, 页码: 319-334 作者:  Qin, Ying;  Li, Dekang;  Qi, Chunting;  Xiang, Huaijiang;  Meng, Huyan   |  收藏  |  浏览/下载：6/0  |  提交时间：2024/03/06 RIPK1  Necroptosis  Type-II kinase inhibitors  Rational design  Lead optimization  Structure-activity relationship  Anti-inflammation  Preclinical drug discovery   Design, synthesis and biological evaluation of salicylanilides as novel allosteric inhibitors of human pancreatic lipase 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 91, 页码: 11 作者:  Zhao, Yitian;  Zhang, Min;  Hou, Xudong;  Han, Jiaxin;  Qin, Xiaoya   |  收藏  |  浏览/下载：12/0  |  提交时间：2023/10/17 Salicylanilide  hPL inhibitor  Structure -activity relationship  Anti -obesity   Elastic network models and molecular dynamic simulations reveal the molecular basis of allosteric regulation in ubiquitin-specific protease 7 (USP7) 期刊论文  OAI收割 COMPUTERS IN BIOLOGY AND MEDICINE, 2023, 卷号: 162, 页码: 10 作者:  Xu, Jing;  Wang, Yiran;  Zhang, Jiali;  Abdelmoneim, Amr Abbas;  Liang, Zhongjie   |  收藏  |  浏览/下载：16/0  |  提交时间：2023/10/17 USP7  Allosteric regulation  Elastic network models  Molecular dynamics simulations   Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers 期刊论文  OAI收割 CELL RESEARCH, 2023, 页码: 13 作者:  Wang, Xinwei;  Wang, Mu;  Xu, Tuo;  Feng, Ye;  Shao, Qiang   |  收藏  |  浏览/下载：12/0  |  提交时间：2023/10/17 Unraveling the catalytic mechanism of SARS-CoV-2 papain-like protease with allosteric modulation of C270 mutation using multiscale computational approaches 期刊论文  OAI收割 CHEMICAL SCIENCE, 2023, 卷号: 14, 期号: 18, 页码: 4681-4696 作者:  Shao, Qiang;  Xiong, Muya;  Li, Jiameng;  Hu, Hangchen;  Su, Haixia   |  收藏  |  浏览/下载：0/0  |  提交时间：2024/03/27 Identification of Cysteine 270 as a Novel Site for Allosteric Modulators of SARS-CoV-2 Papain-Like Protease 期刊论文  OAI收割 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 页码: 10 作者:  Hu, Hangchen;  Wang, Qian;  Su, Haixia;  Shao, Qiang;  Zhao, Wenfeng   |  收藏  |  浏览/下载：11/0  |  提交时间：2023/04/10 Allosteric Modulator  Cysteine 270  Drug Design  Papain-Like Protease  SARS-CoV-2   The allosteric gating mechanism of the MthK channel 期刊论文  OAI收割 NATIONAL SCIENCE REVIEW, 2022, 卷号: 9, 期号: 8, 页码: 12 作者:  Guan, Fenghui;  Li, Tianyu;  Dong, Wei;  Guo, Rui;  Chai, Hao   |  收藏  |  浏览/下载：25/0  |  提交时间：2022/09/30 ion channel  allosteric gating mechanism  protein structural data analysis   The allosteric gating mechanism of the MthK channel 期刊论文  OAI收割 NATIONAL SCIENCE REVIEW, 2022, 卷号: 9 作者:  Guan, Fenghui;  Li, Tianyu;  Dong, Wei;  Guo, Rui;  Chai, Hao   |  收藏  |  浏览/下载：23/0  |  提交时间：2022/12/23 ion channel  allosteric gating mechanism  protein structural data analysis   Parthenolide reveals an allosteric mode to inhibit the deISGylation activity of SARS-CoV-2 papain-like protease 期刊论文  OAI收割 ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2022, 卷号: 54, 期号: 8, 页码: 1133-1139 作者:  Zou, Zhihui;  Shan, Huizhuang;  Sun, Demeng;  Xia, Li;  Shi, Yulong   |  收藏  |  浏览/下载：33/0  |  提交时间：2022/11/11 COVID-19  SARS-CoV-2  PLpro  Parthenolide  deISGylation