中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [5]
上海营养与健康研究所 [3]
过程工程研究所 [2]
海洋研究所 [2]
合肥物质科学研究院 [2]
昆明植物研究所 [1]
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OAI收割 [18]
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期刊论文 [16]
学位论文 [2]
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2024 [2]
2022 [3]
2021 [2]
2020 [2]
2019 [4]
2018 [3]
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Biochemist... [1]
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Paralichthys olivaceus
MLKL-mediated necroptosis is activated by RIPK1/3 and involved in anti-microbial immunity
期刊论文
OAI收割
FRONTIERS IN IMMUNOLOGY, 2024, 卷号: 15, 页码: 11
作者:
Hao, Kangwei
;
Xu, Hang
;
Jiang, Shuai
;
Sun, Li
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/04/07
Paralichthys olivaceus
necroptosis
RIPK1
RIPK3
MLKL
immune defense
Structure-based development of potent and selective type-II kinase inhibitors of RIPK1
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 1, 页码: 319-334
作者:
Qin, Ying
;
Li, Dekang
;
Qi, Chunting
;
Xiang, Huaijiang
;
Meng, Huyan
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/03/06
RIPK1
Necroptosis
Type-II kinase inhibitors
Rational design
Lead optimization
Structure-activity relationship
Anti-inflammation
Preclinical drug discovery
Repurposing of the FGFR inhibitor AZD4547 as a potent inhibitor of necroptosis by selectively targeting RIPK1
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022
作者:
Wang, Zuo-wei
;
Zou, Feng-ming
;
Wang, Ao-li
;
Yang, Jing
;
Jin, Rui
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2022/12/22
AZD4547
RIPK1
inhibitors
SIRS model
anti-necroptosis
The pathogenesis of organ fibrosis: Focus on necroptosis
期刊论文
OAI收割
BRITISH JOURNAL OF PHARMACOLOGY, 2022
作者:
Hao, Min
;
Han, Xin
;
Yao, Zhouhui
;
Zhang, Han
;
Zhao, Mengting
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2022/12/22
liver fibrosis
lung fibrosis
MLKL
necroptosis
RIPK1
3
tissue fibrosis
Alteration of intestinal microecology by oral antibiotics promotes oral squamous cell carcinoma development
期刊论文
OAI收割
MOLECULAR IMMUNOLOGY, 2022, 卷号: 149, 期号: 0, 页码: 94-106
作者:
Wei, Wei
;
Li, Jia
;
Liu, Fan
;
Wu, Miaomiao
;
Xiong, Kaixin
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2022/11/09
CANCER
TYROSINE
METABOLISM
OPPORTUNITIES
NECROPTOSIS
MICROBIOME
DISEASE
VACCINE
HEAD
Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 6
作者:
Yang, Xiangbo
;
Lu, Huimin
;
Xie, Hang
;
Zhang, Binbin
;
Nie, Tianqing
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2022/01/18
Binding studies
Drug discovery
Necroptosis
RIPK1 inhibitors
Sepsis
调控神经胶质细胞生物功能治疗阿尔茨海默病的研究
学位论文
OAI收割
: 中国科学院过程工程研究所, 2021
作者:
张伦
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2023/06/25
阿尔茨海默病,小胶质细胞,星形胶质细胞,Aβ寡聚体,嵌合抗原受体
A Conditionally Releasable "Do not Eat Me" CD47 Signal Facilitates Microglia-Targeted Drug Delivery for the Treatment of Alzheimer's Disease
期刊论文
OAI收割
ADVANCED FUNCTIONAL MATERIALS, 2020, 页码: 10
作者:
Zhang, Lun
;
Liu, Xiao-ge
;
Liu, Dong-qun
;
Yu, Xiao-lin
;
Zhang, Ling-xiao
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/06/15
Alzheimer's Disease
Brain Delivery
Cd47
Microglia
Ripk1
RIPK1 inhibitor ameliorates colitis by directly maintaining intestinal barrier homeostasis and regulating following IECs-immuno crosstalk
期刊论文
OAI收割
BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 172, 页码: 16
作者:
Lu, Huimin
;
Li, Heng
;
Fan, Chen
;
Qi, Qing
;
Yan, Yuxi
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/07/01
RIPK1 inhibitor
Colitis
Barrier homeostasis
IECs-immunocytes crosstalk
Necroptosis
NF-kappa B
Microglia-derived TNF-alpha mediates endothelial necroptosis aggravating blood brain-barrier disruption after ischemic stroke
期刊论文
OAI收割
CELL DEATH & DISEASE, 2019, 卷号: 10, 页码: 18
作者:
Chen, An-Qi
;
Fang, Zhi
  |  
收藏
  |  
浏览/下载:73/0
  |  
提交时间:2019/10/14