中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [11]
昆明植物研究所 [8]
中国科学院大学 [3]
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期刊论文 [31]
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Discovery of pseudolaric acid A as a new Hsp90 inhibitor uncovers its potential anticancer mechanism
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2021, 卷号: 112, 页码: 104963
作者:
Liu,Jiangxin
;
Wu,Xing-De
;
Li,Wenyan
;
Yuan,Zaifeng
;
Yang,Kun
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2022/04/02
Pseudolaric acid A
Hsp90 inhibitor
Apoptosis
NMR
Structure-activity relationship
Photoaffinity-based probe
Protein-ligand interaction
MOLECULAR CHAPERONE
PROTEIN
TARGET
CANCER
KINASE
NMR
IDENTIFICATION
SELECTIVITY
BINDING
DESIGN
Synthesis of nigranoic acid and manwuweizic acid derivatives as HDAC inhibitors and anti-inflammatory agents
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2021, 卷号: 109, 页码: 104728
作者:
Ni,Dong-Xuan
;
Wang,Qi
;
Li,Yi-Ming
;
Cui,Yi-Man
;
Shen,Tian-Ze
  |  
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2022/04/02
Natural products modification
HDAC inhibition
Inflammasome
Triterpenoid
SCHISANDRA-PROPINQUA
TRITERPENOIDS
MECHANISM
INJURY
Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton's tyrosine kinase inhibitors
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 3, 页码: 415-422
作者:
Lai, Meng-zhen
;
Song, Pei-ran
;
Dou, Dou
;
Diao, Yan-yan
;
Tong, Lin-jiang
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
B cell receptor
Bruton's tyrosine kinase
ibrutinib
small-molecule inhibitor
B cell malignancies
Efficient synthesis, biological evaluation, and docking study of isatin based derivatives as caspase inhibitors
期刊论文
OAI收割
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2020, 卷号: 35, 期号: 1, 页码: 1674-1684
作者:
Firoozpour, Loghman
;
Gao, Lixin
;
Moghimi, Setareh
;
Pasalar, Parvin
;
Davoodi, Jamshid
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/12/24
Caspase inhibitor
Isatin sulphonamides
docking studies
Pharmacophore
apoptosis
Development of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates containing piperazine as inhibitors of PI3K alpha
会议论文
OAI收割
作者:
Yin, Yong
;
Zhou, Yang
;
Sha, Shao
;
Wu, Xun
;
Wang, She-Feng
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/12/02
EMBRYONIC LETHALITY
PATHWAY
KINASE
PI3K
DISCOVERY
3-KINASES
SUBUNIT
GROWTH
POTENT
TARGET
MiR-155 affects osteosarcoma cell proliferation and invasion through regulating NF-kappa B signaling pathway
期刊论文
OAI收割
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2018, 卷号: 22, 期号: 22, 页码: 7633-7639
作者:
Lu, S.
;
Liao, Q-S
;
Tang, L.
  |  
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2019/01/22
Mir-155
Nf-kappa b
Osteosarcoma
Proliferation
Invasion
Vitamin E deficiency depressed gill immune response and physical barrier referring to NF-kB, TOR, Nrf2 and MLCK signalling in grass carp (Ctenopharyngodon idella) under infection of Flavobacterium columnare
期刊论文
OAI收割
AQUACULTURE, 2018, 卷号: 484, 期号: 1, 页码: 13-27
作者:
Pan, Jia-Hong
;
Feng, Lin
;
Jiang, Wei-Dan
;
Wu, Pei
;
Kuang, Sheng-Yao
  |  
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2019/07/03
Vitamin E
Grass carp (Ctenopharyngodon idella)
Immunity
Antioxidant capacity
Apoptosis
Tight junction
Gill
Synthesis and inhibitory effect of 10-chlorocanthin-6-one on ovarian cancer HO8910PM cells
期刊论文
OAI收割
BIOTECHNOLOGY LETTERS, 2018, 卷号: 40, 期号: 1, 页码: 23-30
作者:
Li, Wenhua
;
Chen, Yuwen
;
Sheng, Yuwen
;
Xie, Zeyu
;
Tang, Yaxiong
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/12/24
Bim
Cell apoptosis
10-Chlorocanthin-6-one
Cytotoxicity
Ovarian cancer cell line
Discovery of Novel Bromophenol Hybrids as Potential Anticancer Agents through the Ros-Mediated Apoptotic Pathway: Design, Synthesis and Biological Evaluation
期刊论文
OAI收割
MARINE DRUGS, 2017, 卷号: 15, 期号: 11, 页码: 18
作者:
Wang, Li-Jun
;
Guo, Chuan-Long
;
Li, Xiang-Qian
;
Wang, Shuai-Yu
;
Jiang, Bo
  |  
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2019/07/15
bromophenol hybrids
anticancer
structure-activity relationships
ROS
apoptotic pathway
Isoliquiritigenin suppresses IL-1 beta induced apoptosis and inflammation in chondrocyte-like ATDC5 cells by inhibiting NF-kappa B and exerts chondroprotective effects on a mouse model of anterior cruciate ligament transection
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2017, 卷号: 40, 期号: 6, 页码: 1709-1718
作者:
Ji, BC (Ji, Baochao)
;
Guo, WT (Guo, Wentao)
;
Ma, HR (Ma, Hairong)
;
Xu, BY (Xu, Boyong)
;
Mu, WB (Mu, Wenbo)
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2018/01/08
Isoliquiritigenin
Osteoarthritis
Chondrocytes
Anti-apoptosis
Anti-catabolic