中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [34]
大连化学物理研究所 [12]
西北高原生物研究所 [10]
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Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal
期刊论文
OAI收割
CELL STEM CELL, 2022, 卷号: 29, 期号: 9, 页码: 1366-+
作者:
Chen, Li
;
Jiao, Tingying
;
Liu, Weiwei
;
Luo, Yuhong
;
Wang, Jue
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2023/04/10
Liquorice Extract and 18 beta-Glycyrrhetinic Acid Protect Against Experimental Pyrrolizidine Alkaloid-Induced Hepatotoxicity in Rats Through Inhibiting Cytochrome P450-Mediated Metabolic Activation
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13, 页码: 14
作者:
Wang, Zhangting
;
Ma, Jiang
;
Yao, Sheng
;
He, Yisheng
;
Miu, Kai-Kei
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/06/15
18 beta-glycyrrhetinic acid
pyrrolizidine alkaloid
cytochrome P450
metabolic activation
competitive inhibition
Furmonertinib (Alflutinib, AST2818) is a potential positive control drug comparable to rifampin for evaluation of CYP3A4 induction in sandwich-cultured primary human hepatocytes
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Wu, Ya-li
;
Xue, Ya-ru
;
Guo, Zi-tao
;
Chen, Zhen-dong
;
Ge, Xin-yu
  |  
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2021/08/17
furmonertinib (alflutinib
AST2818)
quantitative proteomics
sandwich-cultured human hepatocytes
Functional Proliferating Human Hepatocytes: In Vitro Hepatocyte Model for Drug Metabolism, Excretion, and Toxicity
期刊论文
OAI收割
DRUG METABOLISM AND DISPOSITION, 2021, 卷号: 49, 期号: 4, 页码: 305-313
作者:
Qiao, Shida
;
Feng, Sisi
;
Wu, Zhitao
;
He, Ting
;
Ma, Chen
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/05/24
Exposure to 2,3,3 ',4,4 ',5-hexachlorobiphenyl promotes nonalcoholic fatty liver disease development in C57BL/6 mice
期刊论文
OAI收割
ENVIRONMENTAL POLLUTION, 2020, 卷号: 263, 页码: 1-10
作者:
Shan, Qiuli
;
Chen, Ningning
;
Liu, Wei
;
Qu, Fan
;
Chen, Anhui
  |  
收藏
  |  
浏览/下载:79/0
  |  
提交时间:2021/09/14
NAFLD
PCB 156
Transcriptomics
Lipid accumulation
Oxidative stress
Exposure to 2,3,3 ',4,4 ',5-hexachlorobiphenyl promotes nonalcoholic fatty liver disease development in C57BL/6 mice
期刊论文
OAI收割
ENVIRONMENTAL POLLUTION, 2020, 卷号: 263, 页码: 1-10
作者:
Shan, Qiuli
;
Chen, Ningning
;
Liu, Wei
;
Qu, Fan
;
Chen, Anhui
  |  
收藏
  |  
浏览/下载:80/0
  |  
提交时间:2021/09/14
NAFLD
PCB 156
Transcriptomics
Lipid accumulation
Oxidative stress
Matrix stiffness and shear stresses modulate hepatocyte functions in a fibrotic liver sinusoidal model
期刊论文
OAI收割
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 3, 2020, 卷号: 320, 页码: G272-G282
作者:
Li W(李旺)
;
Li PW(李培文)
;
Li N(李宁)
;
Du Y(杜宇)
;
Lv SQ(吕守芹)
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2022/10/25
hepatocytes
liver fibrosis
matrix stiffness
shear flow
three-dimensional liver sinusoidal model
Intravenous formulation of Panax notoginseng root extract: human pharmacokinetics of ginsenosides and potential for perpetrating drug interactions
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 10, 页码: 1351-1363
作者:
Pintusophon, Salisa
;
Niu, Wei
;
Duan, Xiao-na
;
Olaleye, Olajide E.
;
Huang, Yu-hong
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/07/01
ginsenoside
cytochrome P450 3A
organic anion-transporting polypeptide 1B3
herbal medicine-drug interactions
XueShuanTong
Panax notoginseng
Intestinal and hepatic biotransformation of pyrrolizidine alkaloid N-oxides to toxic pyrrolizidine alkaloids
期刊论文
OAI收割
ARCHIVES OF TOXICOLOGY, 2019, 卷号: 93, 期号: 8, 页码: 2197-2209
作者:
Yang, Mengbi
;
Ma, Jiang
;
Ruan, Jianqing
;
Ye, Yang
;
Fu, Peter Pi-Cheng
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/07/01
Pyrrolizidine alkaloid N-oxides
Pyrrolizidine alkaloids
Pyrrolizidine alkaloid N-oxide toxicity
Biotransformation of pyrrolizidine alkaloid N-oxides
Microbiota biotransformation
Induction of Cytochrome P450 Involved in the Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomes In Vivo
期刊论文
OAI收割
DRUG METABOLISM AND DISPOSITION, 2019, 卷号: 47, 期号: 4, 页码: 364-376
作者:
Wang, Fengling
;
Wu, Yifan
;
Zhang, Jiwen
;
Wang, Huihui
;
Xie, Xiaoting
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/07/01