机构

• 上海药物研究所 [8]
• 中国科学院大学 [1]

采集方式

• OAI收割 [8]
• iSwitch采集 [1]

内容类型

• 期刊论文 [9]

发表日期

• 2023 [2]
• 2018 [3]
• 2017 [1]
• 2016 [3]

学科主题

筛选

浏览/检索结果: 共9条，第1-9条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Discovery, Structure-Activity Relationship and In Vitro Anticancer Activity of Small-Molecule Inhibitors of the Protein-Protein Interactions between AF9/ENL and AF4 or DOT1L 期刊论文  OAI收割 CANCERS, 2023, 卷号: 15, 期号: 21, 页码: 28 作者:  Li, Xin;  Wu, Xiaowei;  Nie, Shenyou;  Zhao, Jidong;  Yao, Yuan   |  收藏  |  浏览/下载：7/0  |  提交时间：2023/12/19 MLL-rearranged leukemia  super elongation complexes  small-molecule inhibitor  protein-protein interaction  cancer therapeutics   Design, synthesis of novel benzimidazole derivatives as ENL inhibitors suppressing leukemia cells viability via downregulating the expression of MYC 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 248, 页码: 14 作者:  Guo, Siqi;  Jia, Tongguan;  Xu, Xiaoming;  Yang, Feng;  Xiao, Senhao   |  收藏  |  浏览/下载：20/0  |  提交时间：2023/04/10 ENL Inhibitor  YEATS domain  Histone lysine acetylation  Benzimidazole derivatives  Acute myeloid leukemia   Design, synthesis and anti leukemia cells proliferation activities of pyrimidylaminoquinoline derivatives as DOT1L inhibitors 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2018, 卷号: 80, 页码: 649-654 作者:  Zhang, Li;  Chen, Yantao;  Liu, Na;  Li, Linjuan;  Xiao, Senhao   |  收藏  |  浏览/下载：37/0  |  提交时间：2019/01/08 Pyrimidylaminoquinoline  Nonnucleoside DOT1L inhibitors  Amino side chains  Mixed-linage leukemia  Histone lysine methyltransferase   Discovery of potent DOT1L inhibitors by AlphaLISA based High Throughput Screening assay 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 8, 页码: 1751-1758 作者:  Song, Yakai;  Li, Linjuan;  Chen, Yantao;  Liu, Jingqiu;  Xiao, Senhao   |  收藏  |  浏览/下载：42/0  |  提交时间：2019/01/08 DOT1L  MLL-rearranged leukemia  AlphaLISA  HTS  Novel inhibitors   Piribedil disrupts the MLL1-WDR5 interaction and sensitizes MLL-rearranged acute myeloid leukemia (AML) to doxorubicin-induced apoptosis 期刊论文  OAI收割 CANCER LETTERS, 2018, 卷号: 431, 页码: 150-160 作者:  Zhang, Xiong;  Zheng, Xingling;  Yang, Hong;  Yan, Juan;  Fu, Xuhong   |  收藏  |  浏览/下载：37/0  |  提交时间：2019/01/08 MLL leukemia  Piribedil  H3K4 methylation  Cell cycle  Apoptosis   Discovery of Novel Disruptor of Silencing Telomeric 1-Like (DOTI L) Inhibitors using a Target-Specific Scoring Function for the (S)-Adenosyl-L-methionine (SAM)-Dependent Methyltransferase Family 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 5, 页码: 2026-2036 作者:  Wang, Yulan;  Li, Linjuan;  Zhang, Bidong;  Xing, Jing;  Chen, Shijie   |  收藏  |  浏览/下载：23/0  |  提交时间：2019/01/08 Discovery of novel inhibitors targeting the menin-mixed lineage leukemia interface using pharmacophore- and docking-based virtual screening 期刊论文  iSwitch采集 Journal of chemical information and modeling, 2016, 卷号: 56, 期号: 9, 页码: 1847-1855 作者:  Xu, Yuan;  Yue, Liyan;  Wang, Yulan;  Xing, Jin;  Chen, Zhifeng 收藏  |  浏览/下载：35/0  |  提交时间：2019/05/09 Discovery of Novel Inhibitors Targeting the Menin-Mixed Lineage Leukemia Interface Using Pharmacophore- and Docking-Based Virtual Screening 期刊论文  OAI收割 JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2016, 卷号: 56, 期号: 9, 页码: 1847-1855 作者:  Xu, Yuan;  Yue, Liyan;  Wang, Yulan;  Xing, Jin;  Chen, Zhifeng   |  收藏  |  浏览/下载：20/0  |  提交时间：2019/01/08 Identification of Novel Disruptor of Telomeric Silencing 1-like (DOT1L) Inhibitors through Structure-Based Virtual Screening and Biological Assays 期刊论文  OAI收割 JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2016, 卷号: 56, 期号: 3, 页码: 527-534 作者:  Chen, Shijie;  Li, Linjuan;  Chen, Yantao;  Hu, Junchi;  Liu, Jingqiu   |  收藏  |  浏览/下载：19/0  |  提交时间：2019/01/08