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浏览/检索结果: 共380条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Discovery of Novel PROTAC Degraders of p300/CBP as Potential Therapeutics for Hepatocellular Carcinoma 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 4, 页码: 2466-2486 作者:  Chang, Qi;  Li, Jiayi;  Deng, Yue;  Zhou, Ruilin;  Wang, Bingwei   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/03/25 Discovery, Structure-Activity Relationship and In Vitro Anticancer Activity of Small-Molecule Inhibitors of the Protein-Protein Interactions between AF9/ENL and AF4 or DOT1L 期刊论文  OAI收割 CANCERS, 2023, 卷号: 15, 期号: 21, 页码: 28 作者:  Li, Xin;  Wu, Xiaowei;  Nie, Shenyou;  Zhao, Jidong;  Yao, Yuan   |  收藏  |  浏览/下载：7/0  |  提交时间：2023/12/19 MLL-rearranged leukemia  super elongation complexes  small-molecule inhibitor  protein-protein interaction  cancer therapeutics   Discovery of ARD-1676 as a Highly Potent and Orally Efficacious AR PROTAC Degrader with a Broad Activity against AR Mutants for the Treatment of AR plus Human Prostate Cancer 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 18, 页码: 13280-13303 作者:  Xiang, Weiguo;  Zhao, Lijie;  Han, Xin;  Xu, Tianfeng;  Kregel, Steven   |  收藏  |  浏览/下载：9/0  |  提交时间：2023/12/08 Preclinical Evaluation of 9MW2821, a Site-Specific Monomethyl Auristatin E-based Antibody-Drug Conjugate for Treatment of Nectin-4-expressing Cancers 期刊论文  OAI收割 MOLECULAR CANCER THERAPEUTICS, 2023, 卷号: 22, 期号: 8, 页码: 913-925 作者:  Zhou, Wei;  Fang, Peng;  Yu, Dongan;  Ren, Hongyuan   |  收藏  |  浏览/下载：11/0  |  提交时间：2023/10/17 YTHDF2 inhibition potentiates radiotherapy antitumor efficacy 期刊论文  OAI收割 CANCER CELL, 2023, 卷号: 41, 期号: 7, 页码: 1294-+ 作者:  Wang, Liangliang;  Dou, Xiaoyang;  Chen, Shijie;  Yu, Xianbin;  Huang, Xiaona   |  收藏  |  浏览/下载：21/0  |  提交时间：2023/10/17 Selective degradation of cellular BRD3 and BRD4-L promoted by PROTAC molecules in six cancer cell lines 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 254, 页码: 17 作者:     |  收藏  |  浏览/下载：25/0  |  提交时间：2023/10/17 Optimization of carbazole carboxamide RORγt agonists: Challenges in improving the metabolic stability and maintaining the agonistic activity 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 251, 页码: 115213 作者:  Sun, Nannan;  Yu, Mingcheng;  Jiang, Zhengyuan;  Yang, Feng;  Lu, Lixue   |  收藏  |  浏览/下载：1/0  |  提交时间：2024/03/27 ROR?t agonists  Carbazole carboxamide  Agonistic activity  Metabolic stability  Co-crystallization  Molecular docking   Living Cells and Cell-Derived Vesicles: A Trojan Horse Technique for Brain Delivery 期刊论文  OAI收割 PHARMACEUTICS, 2023, 卷号: 15, 期号: 4, 页码: 1257 作者:  Ou, Ante;  Wang, Yuewei;  Zhang, Jiaxin;  Huang, Yongzhuo   |  收藏  |  浏览/下载：2/0  |  提交时间：2024/03/27 brain drug delivery  blood-brain barrier (BBB)  Trojan horse delivery systems  cells  extracellular vesicles  cell membranes   Covalent inhibitor targets KRasG12C: A new paradigm for drugging the undruggable and challenges ahead 期刊论文  OAI收割 GENES & DISEASES, 2023, 卷号: 10, 期号: 2, 页码: 403-414 作者:  Li, Hui-yu;  Qi, Wei-liang;  Wang, Yu-xiang;  Meng, Ling-hua   |  收藏  |  浏览/下载：117/0  |  提交时间：2023/10/17 Biomarkers  Covalent KRasG12Cinhibitors  Drug resistance  Human cancers  KRASG12Cmutation   Evaluation of unimodal and multimodal information in health communication on GGO-related lung cancer screening: An eye-tracking study 期刊论文  OAI收割 JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 2023, 卷号: 19, 期号: 1, 页码: 124-+ 作者:  Li, Yuan;  Peng, Yue;  Zhang, Xiaoyu;  Lyu, Baihan;  Zhang, Xiaoxiao   |  收藏  |  浏览/下载：16/0  |  提交时间：2024/01/02 Eye-tracking  health communication  information modality  lung cancer screening