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Chinese Academy of Sciences Institutional Repositories Grid
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Design and synthesis of cantharidin derivative DCZ5418 as a TRIP13 inhibitor with anti-multiple myeloma activity
in
vitro
and
in
vivo
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 98, 页码: 7
作者:
Dong, Sanfeng
;
Hu, Ke
;
Shi, Yulong
;
Wang, Guanli
;
Yu, Dandan
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/02/19
Multiple myeloma
TRIP13 inhibitor
Cantharidin
DCZ5418
DCZ0415
Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC Degraders of Oncogenic KRAS
G12D
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2, 页码: 1147-1167
作者:
Zhou, Chuan
;
Fan, Zisheng
;
Gu, Yuejiao
;
Ge, Zhiming
;
Tao, Zhaofan
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/02/27
Design, Synthesis, and Pharmacological Evaluation of Isoindoline Analogues as New HPK1 Inhibitors
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 23, 页码: 16201-16221
作者:
Xie, Chenghu
;
Liu, Bo
;
Song, Zilan
;
Yang, Ye
;
Dai, Mengdi
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/02/27
Design, synthesis and biological evaluation of chalcone derivatives as potent and orally active hCYP3A4 inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023, 卷号: 95, 页码: 9
作者:
Lu, Shiwei
;
Zhang, Feng
;
Gong, Jiahao
;
Huang, Jian
;
Zhu, Guanghao
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/12/08
Cytochrome P450 3A4 (CYP3A4)
Inhibitors
Isoquinoline chalcones
Orally active
Adaptive structure evolution and biologically plausible synaptic plasticity for recurrent spiking neural networks
期刊论文
OAI收割
SCIENTIFIC REPORTS, 2023, 卷号: 13, 期号: 1, 页码: 13
作者:
Pan, Wenxuan
;
Zhao, Feifei
;
Zeng, Yi
;
Han, Bing
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2023/12/21
Multi-objective optimization on bionic fractal structure for heat exchanging of two fluids by genetic algorithm
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 2023, 卷号: 212, 页码: 124298
作者:
Pan LS(潘利生)
;
Yao ZK(姚子康)
;
Yao W(姚卫)
;
Wei XL(魏小林)
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/07/17
Bionic fractal structure
Thermo-hydraulic performance
Heat transfer enhancement
Genetic algorithm optimization
Discovery, structural optimization, and anti-tumor bioactivity evaluations of betulinic acid derivatives as a new type of ROR & gamma; antagonists
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 257, 页码: 15
作者:
Mei, Lianghe
;
Xu, Lansong
;
Wu, Sanan
;
Wang, Yafang
;
Xu, Chao
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2023/10/17
Betulinic acid
ROR & gamma
Target identification
Rationale structure optimization
Anti-tumor effects
antagonists
Discovery and Structural Optimization of Covalent ZAP-70 Kinase Inhibitors against Psoriasis
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 15
作者:
Rao, Danni
;
Yang, Tao
;
Feng, Huixu
;
An, Qi
;
Zhang, Shaofeng
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2023/10/17
Numerical simulation and optimization of construction: Product prototyping of new raw earth-based energy-saving hollow bricks
期刊论文
OAI收割
JOURNAL OF BUILDING ENGINEERING, 2023, 卷号: 70, 期号: -, 页码: -
作者:
Chen, Ronglin
;
Liu, Haifeng
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/08/02
Mechanical performance
Thermal performance
Hollow bricks
Energy -saving wall materials
Design and Simulation Analysis of Piezoelectric Ceramic Tube-Based Fiber Optic Nutator Applied to an Intersatellite Laser Communication System
期刊论文
OAI收割
PHOTONICS, 2023, 卷号: 10, 期号: 7
作者:
Peng, Bo
;
Ruan, Ping
;
Han, Junfeng
;
Li, Xiangyu
;
Chang, Zhiyuan
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2023/08/18
fiber-optic nutator
piezoelectric ceramic tube
laser communication
lightweight design
simulation
APT system