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Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
西北高原生物研究所 [76]
上海药物研究所 [19]
昆明植物研究所 [17]
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OAI收割 [137]
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期刊论文 [126]
学位论文 [9]
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Discovery of betulinic acid derivatives as gut-restricted TGR5 agonists: Balancing the potency and physicochemical properties
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 144, 页码: 18
作者:
Zhuo, Ning
;
Yun, Ying
;
Zhang, Chenlu
;
Guo, Shimeng
;
Yin, Jianpeng
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/03/25
Type 2 Diabetes
TGR5 agonist
Betulinic acid
Gut-restricted
Gallbladder-filling effects
Kinetophores
Design, synthesis and biological evaluation of betulinic acid derivatives as potential inhibitors of 3CL-protease of SARS-CoV-2
期刊论文
OAI收割
STEROIDS, 2024, 卷号: 202, 页码: 8
作者:
Liu, Yaowen
;
Nie, Tianqing
;
Hou, Jinjun
;
Long, Huali
;
Zhang, Zijia
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/03/13
3CLpro
SARS-CoV-2
Betulinic acid
Natural product
Inhibitory activity
Discovery, structural optimization, and anti-tumor bioactivity evaluations of betulinic acid derivatives as a new type of ROR & gamma; antagonists
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 257, 页码: 15
作者:
Mei, Lianghe
;
Xu, Lansong
;
Wu, Sanan
;
Wang, Yafang
;
Xu, Chao
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2023/10/17
Betulinic acid
ROR & gamma
Target identification
Rationale structure optimization
Anti-tumor effects
antagonists
Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXV. Structurally diverse triterpenoids and diterpenoids from two endangered Pinaceae plants endemic to the Chinese Qinling Mountains and their bioactivities
期刊论文
OAI收割
PHYTOCHEMISTRY, 2022, 卷号: 203, 页码: 14
作者:
Jiang, Wei
;
Zhao, Ze-Yu
;
Tong, Ying-Peng
;
Ma, Guang-Lei
;
Zang, Yi
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2022/09/30
Picea neoveitchii
Larix potaninii var. chinensis
Pinaceae
Endangered plants
Terpenoids
Neoveitchins
Potalarxins
PTP1B
ACC1
Discovery of Betulinic Acid Derivatives as Potent Intestinal Farnesoid X Receptor Antagonists to Ameliorate Nonalcoholic Steatohepatitis
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 21
作者:
Zhang, Chenlu
;
Liu, Yameng
;
Wang, Ying
;
Ge, Xie
;
Jiao, Tingying
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2022/11/11
Synthesis and Biological Evaluation of C-17-Amino-Substituted Pyrazole-Fused Betulinic Acid Derivatives as Novel Agents for Osteoarthritis Treatment
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 18, 页码: 13676-13692
作者:
Wang, Jie
;
Wei, Wenhui
;
Zhang, Xiaofei
;
Cao, Shiqi
;
Hu, Bintao
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/03/21
Identification of Betulinic Acid Derivatives as Potent TGR5 Agonists with Antidiabetic Effects via Humanized TGR5(H88Y) Mutant Mice
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12181-12199
作者:
Yun, Ying
;
Zhang, Chenlu
;
Guo, Shimeng
;
Liang, Xiaoying
;
Lan, Yuan
  |  
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2021/11/04
A review on biomass-derived levulinic acid for application in drug synthesis
期刊论文
OAI收割
CRITICAL REVIEWS IN BIOTECHNOLOGY, 2021, 页码: 34
作者:
Zhang, Mingyue
;
Wang, Nan
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2021/10/27
Biomass
levulinic acid
drug
linkers
medicinal materials
reducing cost
Synthesis of a Hexavalent Betulinic Acid Derivative as a Hemagglutinin-Targeted Influenza Virus Entry Inhibitor
期刊论文
OAI收割
MOLECULAR PHARMACEUTICS, 2020
作者:
Chen, Yingying
;
Wang, Xinchen
;
Zhu, Yinbiao
;
Si, Longlong
;
Zhang, Bo
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2021/01/05
A New 28-Nor-oleanane Triterpene from Excoecaria agallocha
期刊论文
OAI收割
NATURAL PRODUCT COMMUNICATIONS, 2018, 卷号: 13, 期号: 1, 页码: 21-22
作者:
Mo, DJ (Mo, De-Juan)
;
Li, J (Li, Jun)
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2018/02/25
Mangrove
Excoecaria Agallocha
Oleanane Triterpene
28-nor-olean-2 Alpha
3 Beta-dihydroxy-14
17-diene-16-one