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浏览/检索结果: 共692条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers 期刊论文  OAI收割 CANCER LETTERS, 2024, 卷号: 582, 页码: 15 作者:  Lu, Xuxiu;  Yu, Rilei;  Li, Zhen;  Yang, Mengke;  Dai, Jiajia   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/04/07 Acquired resistance  Cancer  NSCLC  JC-010a  SHP2   Discovery of hematopoietic progenitor kinase 1 inhibitors using machine learning-based screening and free energy perturbation 期刊论文  OAI收割 JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2024, 页码: 13 作者:  Feng, Dazhi;  Liu, Bo;  Chen, Zhiwei;  Xu, Jinyi;  Geng, Meiyu   |  收藏  |  浏览/下载：25/0  |  提交时间：2024/02/27 HPK1 inhibitor  machine learning  virtual screening  free energy perturbation  structural modification   Tumor-Associated Macrophage Targeting of Nanomedicines in Cancer Therapy 期刊论文  OAI收割 PHARMACEUTICS, 2024, 卷号: 16, 期号: 1, 页码: 28 作者:  Kang, Xuejia;  Huang, Yongzhuo;  Wang, Huiyuan;  Jadhav, Sanika;  Yue, Zongliang   |  收藏  |  浏览/下载：6/0  |  提交时间：2024/02/27 tumor-associated macrophage  suppressive immune environment  tumor proliferation and metastasis  nanomedicine  targeted delivery systems   Synthesis, evaluation and molecular dynamics study of human toll-like receptor 2/6 specific monoacyl lipopeptides as candidate immunostimulants 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2023, 卷号: 141, 页码: 17 作者:  Zhu, Yueyue;  Liu, Bo;  Chen, Zonglong;  Wang, Xianyang;  Wang, Yujie   |  收藏  |  浏览/下载：8/0  |  提交时间：2023/12/08 Toll -like receptor 2/6 agonists  PamCS  Structure-activity relationship  Lipopeptide  Immunostimulants   Design, Synthesis, and Pharmacological Evaluation of Isoindoline Analogues as New HPK1 Inhibitors 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 23, 页码: 16201-16221 作者:  Xie, Chenghu;  Liu, Bo;  Song, Zilan;  Yang, Ye;  Dai, Mengdi   |  收藏  |  浏览/下载：17/0  |  提交时间：2024/02/27 Design and synthesis of 1H-pyrazolo[3,4-d]pyrimidine derivatives as hematopoietic progenitor kinase 1 (HPK1) inhibitors 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2023, 卷号: 140, 页码: 18 作者:  Zhang, Junjie;  Li, Yan;  Tang, Haotian;  Zhou, Qianqian;  Tong, Linjiang   |  收藏  |  浏览/下载：8/0  |  提交时间：2023/12/08 Cancer immunotherapy  HPK1  Structure -based design  HPK1 inhibitor   Development, methodological evaluation and application of a cell-based TRF assay for analysis of ADCC activity 期刊论文  OAI收割 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023, 卷号: 235, 页码: 7 作者:  Zhu, Xiao;  Gong, Likun;  Qin, Qiuping   |  收藏  |  浏览/下载：12/0  |  提交时间：2023/10/17 Antibody-dependent cell-mediated cytotoxicity  Time-resolved fluorescence  Monoclonal antibody  Antibody-Drug Conjugate  Eu  NK-92 cells   Functional evidence that FGFR regulates MAPK signaling in organizer specification in the gastropod mollusk Lottia peitaihoensis 期刊论文  OAI收割 MARINE LIFE SCIENCE & TECHNOLOGY, 2023, 页码: 12 作者:  Tan, Sujian;  Huan, Pin;  Liu, Baozhong   |  收藏  |  浏览/下载：8/0  |  提交时间：2023/11/30 FGF signaling  Organizer specification  BMP signaling gradient  DV patterning  Mollusk   Breaking Tumor Immunosuppressive Network by Regulating Multiple Nodes with Triadic Drug Delivery Nanoparticles 期刊论文  OAI收割 ACS NANO, 2023, 卷号: 17, 期号: 18, 页码: 17826-17844 作者:  Yan, Wenlu;  Li, Yu;  Zou, Yiting;  Zhu, Runqi;  Wu, Ting   |  收藏  |  浏览/下载：8/0  |  提交时间：2023/12/08 triple-negative breast cancer  antitumor immunity  tumor-associated macrophages  myeloid-derived suppressorcells  immune network  nanoparticle   Discovery and Structural Optimization of Covalent ZAP-70 Kinase Inhibitors against Psoriasis 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 15 作者:  Rao, Danni;  Yang, Tao;  Feng, Huixu;  An, Qi;  Zhang, Shaofeng   |  收藏  |  浏览/下载：9/0  |  提交时间：2023/10/17