中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [16]
大连化学物理研究所 [3]
过程工程研究所 [3]
中国科学院大学 [2]
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Discovery of 5-(3-bromo-2-(2,3-dibromo-4,5-dimethoxybenzyl)-4,5-dimethoxybenzylidene)thiazolidine-2,4-dione as a novel potent protein tyrosine phosphatase 1B inhibitor with antidiabetic properties
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2021, 卷号: 108, 页码: 13
作者:
Jiang, Bo
;
Luo, Jiao
;
Guo, Shuju
;
Wang, Lijun
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2021/05/11
Type 2 diabetes mellitus
Protein tyrosine phosphatase 1B inhibitors
Thiazolidinedione
Insulin signaling
Anti-diabetic activities
Design, synthesis, and cytotoxic activities of novel hybrids of parthenolide and thiazolidinedione via click chemistry
期刊论文
OAI收割
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2019, 页码: 9
作者:
Qiu, Jie
;
Yuan, Chun-Mao
;
Wen, Min
;
Li, Ya-Nan
;
Chen, Juan
  |  
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2019/07/29
Parthenolide-thiazolidinedione hybrids
click chemistry
cytotoxic activities
Peroxisome Proliferator-Activated Receptor gamma and Its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated Insulin Sensitization
期刊论文
OAI收割
MOLECULAR AND CELLULAR BIOLOGY, 2018, 卷号: 38, 期号: 10, 页码: UNSP e00677
作者:
Wang, Qiong A.
;
Zhang, Fang
;
Ye, Risheng
;
An, Yu
;
Shao, Mengle
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/12/09
C/EBP alpha
insulin sensitization
PPAR gamma
thiazolidinedione
adipocyte
adipose tissue
inducible knockout
mouse model
obesity
A DFT/TD-DFT study of thiazolidinedione derivative in dimethylformamide: Cooperative roles of hydrogen bondings;electronic and vibrational spectra
期刊论文
OAI收割
spectrochimica acta part a-molecular and biomolecular spectroscopy, 2014, 卷号: 125, 期号: 1, 页码: 131
作者:
Wang DD(王丹丹)
;
Lv R(吕锐)
;
Yuan MH(袁明虎)
;
Fu AP(傅爱萍)
;
Chu TS(楚天舒)
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2015/11/16
Photoinduced coupled twisted intramolecular charge transfer and excited-state proton transfer via intermolecular hydrogen bonding: A DFT/TD-DFT study
期刊论文
OAI收割
chemical physics letters, 2014, 卷号: 610, 页码: 179-185
作者:
Wang, Dandan
;
Lu, Rui
;
Yuan, Minghu
;
Chen, Junsheng
;
Feng, Liqiang
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2015/11/17
A DFT/TD-DFT study of thiazolidinedione derivative in dimethylformamide: Cooperative roles of hydrogen bondings, electronic and vibrational spectra
期刊论文
OAI收割
spectrochimica acta part a-molecular and biomolecular spectroscopy, 2014, 卷号: 125, 页码: 131-137
作者:
Wang, Dandan
;
Lu, Rui
;
Yuan, Minghu
;
Fu, Aiping
;
Chu, Tianshu
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2015/11/13
The time-dependent density functional theory
Hydrogen bonding dynamics
Hydrogen-bonding strengthening and weakening
Excited state
Spectral shift
Photoexcitation
Rosiglitazone Causes Cardiotoxicity via Peroxisome Proliferator-Activated Receptor gamma-Independent Mitochondrial Oxidative Stress in Mouse Hearts
期刊论文
OAI收割
TOXICOLOGICAL SCIENCES, 2014, 卷号: 138, 期号: 2, 页码: 468-481
作者:
He, Huamei
;
Tao, Hai
;
Xiong, Hui
;
Duan, ShengZhong(段胜仲)
;
McGowan, Francis X., Jr.
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2015/09/02
Rosiglitazone
PPAR gamma
energy metabolism
cardiac function
mitochondria
oxidative stress
Identification and Mechanism of 10-Carbon Fatty Acid as Modulating Ligand of Peroxisome Proliferator-activated Receptors
期刊论文
OAI收割
JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 卷号: 287, 期号: 1, 页码: 183-195
作者:
Malapaka, Raghu R. V.
;
Khoo, SokKean
;
Zhang, Jifeng
;
Choi, Jang H.
;
Zhou, X. Edward
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/01/08
Discovery of novel dual functional agent as PPAR gamma agonist and 11 beta-HSD1 inhibitor for the treatment of diabetes
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 卷号: 17, 期号: 15, 页码: 5722-5732
作者:
Ye, Yang-liang
;
Zhou, Zhou
;
Zou, Han-jun
;
Shen, Yu
;
Xu, Ti-fei
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
Type 2 diabetes
PPAR gamma agonists
11 beta-HSD1 inhibitors
Molecular modeling