中国科学院机构知识库网格
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上海药物研究所 [100]
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期刊论文 [127]
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New chromone derivatives bearing thiazolidine-2,4-dione moiety as potent PTP1B inhibitors: Synthesis and biological activity evaluation
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 143, 页码: 9
作者:
Zheng, Yingying
;
Lu, Li
;
Li, Mengyue
;
Xu, Dehua
;
Zhang, Laishun
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/01/26
Chromone
Thiazolidine-2
4-dione
Protein tyrosine phosphatase 1B
Inhibitors
Exploring the mechanism of the PTP1B inhibitors by molecular dynamics and experimental study
期刊论文
OAI收割
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2023, 卷号: 125, 页码: 12
作者:
Zhao, Tian-Tian
;
Hu, Hao-Jie
;
Gao, Li-Xin
;
Zhou, Yu-Bo
;
Zhu, Yun-Long
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/10/17
Protein tyrosine phosphatases inhibitors
PTP1B inhibitors
Mechanism study
Molecular dynamics
Root-Extracted lignanamides from Limonium gmelinii (Willd.) Kuntze with a potential PTP1B inhibitory activity by regulating PI3K/AKT signaling pathway
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 132, 页码: 9
作者:
Tuohongerbieke, Amanguli
;
Liu, Liu
;
Li, Jun
;
Xin, Xuelei
;
Aisa, Haji Akber
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/10/17
Limonium gmelinii (Willd
) Kuntze
Plumbaginaceae
Lignanamides
Protein tyrosine phosphatase 1B inhibitors
PI3K
AKT Signaling Pathway
Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXV. Structurally diverse triterpenoids and diterpenoids from two endangered Pinaceae plants endemic to the Chinese Qinling Mountains and their bioactivities
期刊论文
OAI收割
PHYTOCHEMISTRY, 2022, 卷号: 203, 页码: 14
作者:
Jiang, Wei
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2022/09/30
Picea neoveitchii
Larix potaninii var. chinensis
Pinaceae
Endangered plants
Terpenoids
Neoveitchins
Potalarxins
PTP1B
ACC1
Macrocephatriolides A and B: Two Guaianolide Trimers from Ainsliaea macrocephala as PTP1B Inhibitors and Insulin Sensitizers
期刊论文
OAI收割
JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 86, 期号: 24, 页码: 17782-17789
作者:
Ren, Yong-Mei
;
Zhang, Rui
;
Feng, Zheling
;
Ke, Chang-Qiang
;
Yao, Sheng
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/06/15
Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 13
作者:
Meng, Xiang-Dong
;
Gao, Li-Xin
;
Wang, Zhi-Jia
;
Feng, Bo
;
Zhang, Chun
  |  
收藏
  |  
浏览/下载:61/0
  |  
提交时间:2021/12/01
2,5-diphenyl-1,3,4-oxadiazole derivatives
SHP2
Inhibitors
Structure-activity relationships (SAR)
Synthesis and Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Activity Evaluation of Novel N-Acylhydrazone Derivatives Containing Carbazole and Aromatic Ring/Aromatic Fused Heterocycle
期刊论文
OAI收割
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 9, 页码: 3593-3607
作者:
Li Yingjun
;
Lin Ledi
;
Liu Jihong
;
Gao Lixin
;
Sheng Li
  |  
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/12/01
PTP1B inhibitor
carbazole
N-actylhydrazone
synthesis
molecular docking
Rearranged Diels-Alder Adducts and Prenylated Flavonoids as Potential PTP1B Inhibitors from Morus nigra
期刊论文
OAI收割
JOURNAL OF NATURAL PRODUCTS, 2021, 卷号: 84, 期号: 8, 页码: 2303-2311
作者:
Qu, Ke-Jun
;
Wang, Bin
;
Jiang, Chang-Sheng
;
Xie, Bao-Gang
;
Liu, Ai-Hong
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/11/04
Synthesis and Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Activity Evaluation of Novel Arylaminoacetylhydrazone Derivatives Containing Carbazole Moiety
期刊论文
OAI收割
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3157-3170
作者:
Li Yingjun
;
Lin Ledi
;
Jin Kun
;
Gao Lixin
;
Sheng Li
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2021/11/04
protein tyrosine phosphatase 1B (PTP1B) inhibitor
carbazole
arylaminoacetylhydrazone
synthesis
molecular docking
多花蒿烯内酯H等三种萜类化合物 衍生物合成与抗肝癌和降血糖活性
学位论文
OAI收割
2021
作者:
杨晓烔
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2024/03/20