中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [64]
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Pharmacology and anti-addiction effects of the novel kappa opioid receptor agonist Mesyl Sal B, a potent and long-acting analogue of salvinorin A
期刊论文
OAI收割
出版物, 3111, 期号: 0, 页码: 1-53
作者:
B Simonson
;
A S Morani
;
A W M Ewald
;
L Walker
;
N Kumar
  |  
收藏
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浏览/下载:136/0
  |  
提交时间:2017/07/24
The claustrum-prelimbic cortex circuit through dynorphin/κ-opioid receptor signaling underlies depression-like behaviors associated with social stress etiology
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 17
作者:
Wang, Yu-Jun
;
Zan, Gui-Ying
;
Xu, Cenglin
;
Li, Xue-Ping
;
Shu, Xuelian
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/02/19
Reversal of subtype-selectivity and function by the introduction of a para-benzamidyl substituent to N-cyclopropylmethyl nornepenthone
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 258, 页码: 15
作者:
Kong, Linghui
;
Ning, Kuan
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/10/17
N-cyclopropylmethyl nornepenthone derivatives
derivatives
Structure-activity relationship
MOR antagonist
Functional reversal
Reversal of subtype-selectivity
Opioid use disorder
Prelimbic cortex dynorphin/& kappa; opioid receptor system modulates methamphetamine-induced cognitive impairment
期刊论文
OAI收割
ADDICTION BIOLOGY, 2023, 卷号: 28, 期号: 9, 页码: 12
作者:
Cheng, Ying-jie
;
Deng, Ying-zhi
;
Deng, Di
;
Wu, Man-qing
;
Chai, Jing-rui
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2023/10/17
cognitive impairment
dynorphin
methamphetamine
prelimbic cortex
& kappa
opioid receptor
Upregulation of dynorphin/kappa opioid receptor system in the dorsal hippocampus contributes to morphine withdrawal-induced place aversion
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 8
作者:
Chen, Yan
;
Wang, Chen-yao
;
Zan, Gui-ying
;
Yao, Song-yu
;
Deng, Ying-zhi
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2022/11/11
morphine withdrawal
conditioned place aversion
kappa opioid receptor
p38 MAPK
norBNI
dorsal hippocampus
SLL-627 Is a Highly Selective and Potent ? Opioid Receptor (KOR) Agonist with an Unexpected Nonreduction in Locomotor Activity
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 16
作者:
Kong, Linghui
;
Shu, Xuelian
;
Tang, Siyuan
;
Ye, Rongrong
;
Sun, Huijiao
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收藏
  |  
浏览/下载:42/0
  |  
提交时间:2022/08/30
Antinociceptive activities and mechanism of action of Cepharanthine
期刊论文
OAI收割
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2022, 卷号: 614, 页码: 219-224
作者:
Wei, Xiang-Yan
;
Long, Jian-Dong
;
Chai, Jing-Rui
;
Chen, Jing
;
Gao, Jian-Ping
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2022/08/16
Cepharanthine
Antinociception
mu opioid receptors
Constipation
Novel selective kappa agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Wei, Yuan-yuan
;
Ma, Yan
;
Yao, Song-yu
;
Kong, Ling-hui
;
Liu, Xiao
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收藏
  |  
浏览/下载:36/0
  |  
提交时间:2021/11/04
kappa-opioid receptor agonist
4,5-expoxymorphinan
antinociception
conditioned place aversion
sedation
U50,488H
morphine
Nor-BNI
beta-FNA
Discovery of an M-Substituted N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active kappa-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12414-12433
作者:
He, Qian
;
Wei, Yuanyuan
;
Liu, Xiao
;
Ye, Rongrong
;
Kong, Linghui
  |  
收藏
  |  
浏览/下载:83/0
  |  
提交时间:2021/11/04
Amygdala dynorphin/kappa opioid receptor system modulates depressive-like behavior in mice following chronic social defeat stress
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Zan, Gui-ying
;
Sun, Xiang
;
Wang, Yu-jun
;
Liu, Rui
;
Wang, Chen-yao
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2021/08/17
depression
social defeat stress
amygdala
κ
opioid receptor
dynorphin
c-fos
ERK
norBNI