中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [1885]
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Eliminating drug target interference with specific antibody or its F(ab′)
2
fragment in the bridging immunogenicity assay
期刊论文
OAI收割
BIOANALYSIS, 2024, 页码: 14
作者:
Deng, Xiaojie
;
Hou, Yingying
;
Yuan, Wenyi
;
Yang, Hongzhou
;
Guo, Ruowen
  |  
收藏
  |  
浏览/下载:135/0
  |  
提交时间:2024/04/09
anti-drug antibody
IgE
immunogenicity
mitigation
target interference
Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses
期刊论文
OAI收割
NATURE CHEMICAL BIOLOGY, 2024, 页码: 29
作者:
Zhou, Xiaoyu
;
Zhao, Cheng
;
Xu, Haiyan
;
Xu, Yixiang
;
Zhan, Li
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/03/25
Meta-MolNet: A Cross-Domain Benchmark for Few Examples Drug Discovery
期刊论文
OAI收割
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS, 2024, 页码: 15
作者:
Lv, Qiujie
;
Chen, Guanxing
;
Yang, Ziduo
;
Zhong, Weihe
;
Chen, Calvin Yu-Chian
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/04/09
Benchmark platform
cross-domain meta-learning
drug discovery
few examples
Meta-MolNet
molecular property
Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G
s
proteins
期刊论文
OAI收割
CELL DISCOVERY, 2024, 卷号: 10, 期号: 1, 页码: 13
作者:
Cong, Zhaotong
;
Zhao, Fenghui
;
Li, Yang
;
Luo, Gan
;
Mai, Yiting
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2024/03/13
Nanobodies as negative allosteric modulators for human calcium sensing receptor
期刊论文
OAI收割
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2024, 卷号: 695, 页码: 9
作者:
Cui, Qianqian
;
Wang, Lu
;
Wang, Haonan
;
Chen, Xiaochen
;
Han, Li
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/04/09
G-protein-coupled receptor
Extracellular calcium sensing receptor
Nanobody
Cryo-electron microscope
Systemic Ca 2+homoeostasis
Intelligent design and construction of novel APN-based theranostic probe driven by advanced computational methods
期刊论文
OAI收割
CHINESE CHEMICAL LETTERS, 2024, 卷号: 35, 期号: 2, 页码: 6
作者:
Zhu, Yingli
;
Qian, Jie
;
Yu, Kunqian
;
Hou, Jing
;
Ma, Yeshuo
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/01/26
Theranostic probe
Artificial intelligence
Conformational restriction
Fluorescence restoration
Design strategy
pH-responsive nanogels with enhanced antioxidant and antitumor activities on drug delivery and smart drug release
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 卷号: 257, 页码: 16
作者:
Ma, Bing
;
Li, Qing
;
Mi, Yingqi
;
Zhang, Jingjing
;
Tan, Wenqiang
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/01/26
Benzimidazole-chitosan quaternary ammonium
salt
Nanogels
pH-responsive
Antioxidant activity
Antitumor activity
Application of ensemble learning for predicting GABA
A
receptor agonists
期刊论文
OAI收割
COMPUTERS IN BIOLOGY AND MEDICINE, 2024, 卷号: 169, 页码: 13
作者:
Xiao, Fu
;
Ding, Xiaoyu
;
Shi, Yan
;
Wang, Dingyan
;
Wang, Yitian
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/03/25
GABA(A )receptor
Benzodiazepine
Agonist
Machine learning
Classification
Discovery of a potent and selective covalent threonine tyrosine kinase (TTK) inhibitor
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 143, 页码: 16
作者:
Sun, Yaoliang
;
Chen, Zhiwen
;
Liu, Guobin
;
Chen, Xiaoai
;
Shi, Zihan
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/03/25
Inhibitor
Cancer
Threonine tyrosine kinase (TTK)
Covalent
Recent advances in antibody glycoengineering for the of functions
期刊论文
OAI收割
CURRENT OPINION IN CHEMICAL BIOLOGY, 2024, 卷号: 78, 页码: 10
作者:
Liu, Zhi
;
Zou, Xiangman
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/03/06
Antibody glycoengineering
Endoglycosidase
Chemo-enzymatic
Glycosyltransferase
Antibody-drug conjugates