中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [113]
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期刊论文 [273]
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NIR-II fluorescence-guided liver cancer surgery by a small molecular HDAC6 targeting probe
期刊论文
OAI收割
EBIOMEDICINE, 2023, 卷号: 98, 页码: 18
作者:
Wang, Bo
;
Tang, Chu
;
Lin, En
;
Jia, Xiaohua
;
Xie, Ganyuan
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/02/22
Hepatocellular carcinoma
Second near-infrared window
Molecular imaging
HDAC6
Fluorescence guided surgery
TI17, a novel compound, exerts anti-MM activity by impairing Trip13 function of DSBs repair and enhancing DNA damage
期刊论文
OAI收割
CANCER MEDICINE, 2023, 页码: 14
作者:
Chang, Shuaikang
;
Xiao, Wenqin
;
Xie, Yongsheng
;
Xu, Zhijian
;
Li, Bo
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2023/12/11
DNA damage
DSBs repair
myeloma
TI17
Trip13
Design, synthesis of auristatins-glucuronide conjugates targeting the β-glucuronidase in tumor microenvironment
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023, 卷号: 95, 页码: 5
作者:
Wang, Yujie
;
Xu, Keshi
;
Liu, Hongchun
;
Zhang, Wei
;
Hu, Chun
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2023/12/19
Auristatin E
beta-Glucuronidase
Antiproliferation
Tumor microenvironment
Design, synthesis, and biological evaluation of novel spirocyclic compounds as potential anti-glioblastoma agents
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 258, 页码: 22
作者:
Zhu, Heping
;
Song, Xiaomin
;
Pan, Yihui
;
Li, Ming
;
Chen, Liang
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/10/17
Glioblastoma
Spirocyclic compounds
Drug design
Antiproliferation
[
68
Ga]Ga-AUNP-12 PET imaging to assess the PD-L1 status in preclinical and first-in-human study
期刊论文
OAI收割
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2023, 页码: 11
作者:
Zhou, Ming
;
Xiang, Shijun
;
Zhao, Yajie
;
Tang, Yongxiang
;
Yang, Jinhui
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2023/11/16
PD-1/PD-L1
Immune checkpoints
PET/CT imaging
Immunotherapy
Discovery of ARD-1676 as a Highly Potent and Orally Efficacious AR PROTAC Degrader with a Broad Activity against AR Mutants for the Treatment of AR plus Human Prostate Cancer
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 18, 页码: 13280-13303
作者:
Xiang, Weiguo
;
Zhao, Lijie
;
Han, Xin
;
Xu, Tianfeng
;
Kregel, Steven
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2023/12/08
Discovery, structural optimization, and anti-tumor bioactivity evaluations of betulinic acid derivatives as a new type of ROR & gamma; antagonists
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 257, 页码: 15
作者:
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2023/10/17
Betulinic acid
ROR & gamma
Target identification
Rationale structure optimization
Anti-tumor effects
antagonists
Discovery of 2-Aminopyrimidine Derivatives as Potent Dual FLT3/CHK1 Inhibitors with Significantly Reduced hERG Inhibitory Activities
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 23
作者:
Li, Xuemei
;
Wang, Peipei
;
Wang, Chang
;
Jin, Tingting
;
Xu, Ran
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2023/10/17
Novel thieno[2,3-b]quinoline-procaine hybrid molecules: A new class of allosteric SHP-1 activators evolved from PTP1B inhibitors
期刊论文
OAI收割
CHINESE CHEMICAL LETTERS, 2023, 卷号: 34, 期号: 8, 页码: 6
作者:
Xu, Lei
;
Xuyan, Xuyang
;
Minmi, Minmin
;
Wang, Zhiji
;
Shee, Chao
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2023/10/17
Activator
PTPs
Inhibitor
Thieno[2
b ]quinoline derivatives
Diffuse large B-cell lymphoma
Fibroblast Activation Protein Targeting Probe with Gly-Pro Sequence for PET of Glioblastoma
期刊论文
OAI收割
MOLECULAR PHARMACEUTICS, 2023, 卷号: 20, 期号: 8, 页码: 4120-4128
作者:
Lai, Chaoquan
;
Cao, Rui
;
Li, Renda
;
He, Chunfeng
;
Wang, Xiao
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2023/10/17
glioblastoma
fibroblast activation protein
FAPI
PET imaging