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SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors 期刊论文  OAI收割
CELL RESEARCH, 2022, 页码: 21
作者:  Wang, Xiaomin;  Chen, Ziqi;  Xu, Jun;  Tang, Shuai;  An, Nan
  |  收藏  |  浏览/下载：39/0  |  提交时间：2022/06/15
Synthesis and Evaluation of 3-(Indol-3-yl)-4-(Pyrazolo[3,4-c]Pyridazin-3-yl)-Maleimides as Potent Mutant Isocitrate Dehydrogenase-1 Inhibitors 期刊论文  OAI收割
PHARMACEUTICAL CHEMISTRY JOURNAL, 2021, 卷号: 55, 期号: 7, 页码: 655-664
作者:  Xu, Jianghong;  Hu, Yuanyuan;  Liu, Xiaoqi;  Gao, Anhui;  Gao, Lixin
  |  收藏  |  浏览/下载：47/0  |  提交时间：2021/12/01
Reprogramming the immunosuppressive microenvironment of IDH1 wild-type glioblastoma by blocking Wnt signaling between microglia and cancer cells 期刊论文  OAI收割
ONCOIMMUNOLOGY, 2021, 卷号: 10, 期号: 1, 页码: 13
作者:  Fan, Dandan;  Yue, Qi;  Chen, Jian;  Wang, Cong;  Yu, Ruilin
  |  收藏  |  浏览/下载：34/0  |  提交时间：2021/08/17
Discovery of Novel IDH1 Inhibitor Through Comparative Structure-Based Virtual Screening 期刊论文  OAI收割
FRONTIERS IN PHARMACOLOGY, 2020, 卷号: 11, 页码: 11
作者:  Wang, Yuwei;  Tang, Shuai;  Lai, Huanling;  Jin, Ruyi;  Long, Xu
  |  收藏  |  浏览/下载：52/0  |  提交时间：2020/12/24
Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells 期刊论文  OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 19
作者:  Che, Jinxin;  Huang, Feng;  Zhang, Mengmeng;  Xu, Gaoya;  Qu, Bingxue
  |  收藏  |  浏览/下载：41/0  |  提交时间：2020/12/21
Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells 期刊论文  OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 19
作者:  Che, Jinxin;  Huang, Feng;  Zhang, Mengmeng
  |  收藏  |  浏览/下载：26/0  |  提交时间：2020/12/21
Identification and characterization of isocitrate dehydrogenase 1 (IDH1) as a functional target of marine natural product grincamycin B 期刊论文  OAI收割
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 13
作者:  Wang, Zheng;  Li, Zeng-xia;  Zhao, Wen-cao;  Huang, Hong-bo;  Wang, Jia-qi
  |  收藏  |  浏览/下载：54/0  |  提交时间：2020/12/24
Mutant isocitrate dehydrogenase driven metabolic reprogramming results in therapeutic vulnerability to lactate dehydrogenase inhibition 期刊论文  OAI收割
CANCER RESEARCH, 2020, 卷号: 80, 期号: 16, 页码: 2
作者:  Bi, Aiwei;  Xu, Jun;  Jin, Nan;  Lan, Xiaojing;  Tang, Shuai
  |  收藏  |  浏览/下载：18/0  |  提交时间：2021/05/24
Pharmacological characterization of TQ05310, a potent inhibitor of isocitrate dehydrogenase 2 R140Q and R172K mutants 期刊论文  OAI收割
CANCER SCIENCE, 2019, 页码: 9
作者:  Gao, Mingzhao;  Zhu, Hongmei;  Fu, Li;  Li, Yun;  Bao, Xubin
  |  收藏  |  浏览/下载：28/0  |  提交时间：2020/07/01
AG-221  IDH2  leukemia  R140Q  R172K  
Discovery of DC_H31 as potential mutant IDH1 inhibitor through NADPH-based high throughput screening 期刊论文  OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 15, 页码: 3229-3236
作者:  Duan, Zhe;  Liu, Jingqiu;  Niu, Liping;  Wang, Jun;  Feng, Mingqian
  |  收藏  |  浏览/下载：24/0  |  提交时间：2020/07/01