中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [160]
自动化研究所 [102]
合肥物质科学研究院 [93]
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OAI收割 [978]
内容类型
期刊论文 [892]
会议论文 [61]
学位论文 [21]
专利 [2]
预印本 [2]
发表日期
2022 [978]
学科主题
Plant Sci... [12]
天文学 [7]
Energy & F... [5]
Engineerin... [5]
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浏览/检索结果:
共978条,第1-10条
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发表日期:2022
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Design and synthesis of chromone-nitrogen mustard derivatives and evaluation of anti-breast cancer activity
期刊论文
OAI收割
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 卷号: 37, 期号: 1, 页码: 431-444
作者:
Sun, Jianan
;
Mu, Jiahui
;
Wang, Shenglin
;
Jia, Cai
;
Li, Dahong
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2022/06/15
Chromone
nitrogen mustard
breast cancer
apoptosis
Design, synthesis, and biological evaluation of novel carbazole derivatives as potent DNMT1 inhibitors with reasonable PK properties
期刊论文
OAI收割
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 卷号: 37, 期号: 1, 页码: 1537-1555
作者:
Li, Ennian
;
Wang, Kai
;
Zhang, Bei
;
Guo, Siqi
;
Xiao, Senhao
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2022/08/16
DNMT1 inhibitor
A549 cell lines
HCT116 cell lines
antitumor activity
pharmacokinetic
Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as novel and potent TBK1 inhibitors: design, synthesis, biological evaluation, and molecular docking study
期刊论文
OAI收割
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 卷号: 37, 期号: 1, 页码: 1411-1425
作者:
Sun, Yin
;
Tang, Haotian
;
Wang, Xiaoyan
;
Feng, Fang
;
Fan, Tiantian
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2022/08/16
TBK1 inhibitors
1H-pyrazolo[3
4-b]pyridine
structure-activity relationships (SARs)
immune response
cancer therapy
Linking genetic markers with an eco-physiological model to pyramid favourable alleles and design wheat ideotypes
期刊论文
OAI收割
PLANT CELL AND ENVIRONMENT, 2022, 页码: 16
作者:
Li, Yibo
;
Tao, Fulu
;
Hao, Yuanfeng
;
Tong, Jingyang
;
Xiao, Yonggui
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2023/01/30
eco-physiological modelling
gene-based modelling
genotype-phenotype relationships
GWAS
ideotyping
Linking genetic markers with an eco-physiological model to pyramid favourable alleles and design wheat ideotypes
期刊论文
OAI收割
PLANT CELL AND ENVIRONMENT, 2022, 页码: 16
作者:
Li, Yibo
;
Tao, Fulu
;
Hao, Yuanfeng
;
Tong, Jingyang
;
Xiao, Yonggui
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2023/01/30
eco-physiological modelling
gene-based modelling
genotype-phenotype relationships
GWAS
ideotyping
Ligand recognition and activation of neuromedin U receptor 2
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2022, 卷号: 13, 期号: 1, 页码: 7955
作者:
Zhao, Wenli
;
Zhang, Wenru
;
Wang, Mu
;
Lu, Minmin
;
Chen, Shutian
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/03/21
Discovery of Highly Potent Nicotinamide Phosphoribosyltransferase Degraders for Efficient Treatment of Ovarian Cancer
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 15
作者:
Bi, Kaijian
;
Cheng, Junfei
;
He, Shipeng
;
Fang, Yuxin
;
Huang, Min
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2023/04/10
A self-powered flexible gas-sensing system based on single-wall carbon nanotube films
期刊论文
OAI收割
CELL REPORTS PHYSICAL SCIENCE, 2022, 卷号: 3, 期号: 12, 页码: 12
作者:
Guo, Shu-Yu
;
Hu, Xian-Gan
;
Hou, Peng-Xiang
;
Liu, Zhu
;
Zhzo, Yi-Min
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2023/05/09
Optimized Synthesis of a Key Intermediate of Nirmatrelvir
期刊论文
OAI收割
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2022, 页码: 6
作者:
Qin, Hongjian
;
Jin, Chen
;
Odilov, Abdullajon
;
Bonku, Emmanuel Mintah
;
Zhu, Fuqiang
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/04/10
alpha-cyanomethylation
neodymium chloride
hydrogenation
one-pot
cyclic glutamine analog
Nirmatrelvir
Discovery of 10H-Benzo[b]pyrido[2,3-e][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 15
作者:
Zhan, Zhengsheng
;
Ji, Yinchun
;
Su, Haixia
;
Fang, Chen
;
Peng, Xia
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2023/04/10