中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [74]
采集方式
OAI收割 [74]
内容类型
期刊论文 [73]
会议论文 [1]
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2024 [1]
2023 [10]
2022 [9]
2021 [7]
2020 [9]
2019 [4]
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浏览/检索结果:
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专题:上海药物研究所
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Proteomics analysis of histone deacetylase inhibitor-resistant solid tumors reveals resistant signatures and potential drug combinations
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 11
作者:
Hao, Bing-bing
;
Ma, Ke
;
Xu, Jun-yu
;
Fan, Ru-feng
;
Zhao, Wen-si
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/03/25
solid tumor
histone deacetylase inhibitor
vorinostat (SAHA)
drug resistance
proteomics
A first-in-human phase 1 study of simnotrelvir, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects
期刊论文
OAI收割
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023, 卷号: 191, 页码: 9
作者:
Yang, Xin-Mei
;
Yang, Yang
;
Yao, Bu-Fan
;
Ye, Pan-Pan
;
Xu, Yan
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/12/11
COVID-19
Simnotrelvir
Safety
Pharmacokinetics
Healthy subjects
Anxiolytic effect of antidiabetic metformin is mediated by AMPK activation in mPFC inhibitory neurons
期刊论文
OAI收割
MOLECULAR PSYCHIATRY, 2023, 页码: 11
作者:
Zhang, Yong-mei
;
Zong, Hai-chao
;
Qi, Ying-bei
;
Chang, Liu-liu
;
Gao, Ya-nan
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/12/08
Deciphering the functional landscape of phosphosites with deep neural network
期刊论文
OAI收割
CELL REPORTS, 2023, 卷号: 42, 期号: 9, 页码: 23
作者:
Liang, Zhongjie
;
Liu, Tonghai
;
Li, Qi
;
Zhang, Guangyu
;
Zhang, Bei
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2023/12/08
Structure-Based Ligand Discovery Targeting the Transmembrane Domain of Frizzled Receptor FZD7
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 14
作者:
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2023/10/17
Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors
期刊论文
OAI收割
CELL DISCOVERY, 2023, 卷号: 9, 期号: 1, 页码: 15
作者:
Feng, Wenbo
;
Zhou, Qingtong
;
Chen, Xianyue
;
Dai, Antao
;
Cai, Xiaoqing
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2023/10/17
Chloroquine enhances the efficacy of chemotherapy drugs against acute myeloid leukemia by inactivating the autophagy pathway
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 11
作者:
Wang, Han-lin
;
Li, Jia-nan
;
Kan, Wei-juan
;
Xu, Gao-ya
;
Luo, Guang-hao
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2023/10/17
acute myeloid leukemia
cytarabine
daunorubicin
idarubicin
drug resistant
multi-omics
autophagy
chloroquine phosphate
Hypsochromic Shift Donor-Acceptor NIR-II Dye for High-Efficiency Tumor Imaging
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 14
作者:
Li, Jiafeng
;
Ji, Aiyan
;
Lei, Meiling
;
Xuan, Liwen
;
Song, Ruihu
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2023/10/17
Rhodium(III)-Catalyzed C-H/O2 Dual Activation and Macrocyclization: Synthesis and Evaluation of Pyrido[2,1-a]isoindole Grafted Macrocyclic Inhibitors for Influenza H1N1
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2023, 卷号: 62, 期号: 15
作者:
Song, Bichao
;
Guo, Xueying
;
Yang, Li
;
Yu, Haiyue
;
Zong, Xinlei
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/03/27
C-H Activation
Macrocyclization
Multicomponent Coupling
O-2 Activation
Rh Catalysis
Improved 2α-Hydroxylation Efficiency of Steroids by CYP154C2 Using Structure-Guided Rational Design
期刊论文
OAI收割
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2023, 卷号: 89, 期号: 3
作者:
Gao, Qilin
;
Ma, Bingbing
;
Wang, Qianwen
;
Zhang, Hao
;
Fushinobu, Shinya
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/03/27
P450
testosterone
androstenedione
crystal structure
rational design