中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [15]
采集方式
OAI收割 [15]
内容类型
期刊论文 [15]
发表日期
2023 [2]
2022 [2]
2021 [2]
2019 [2]
2017 [1]
2016 [2]
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专题:上海药物研究所
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Discovery of novel isopropanolamine inhibitors against MoTPS1 as potential fungicides with unique mechanisms
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 260, 页码: 14
作者:
Jiang, Zhiyang
;
Shi, Dongmei
;
Chen, Yitong
;
Li, Huilin
;
Wang, Jin 'e
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/12/08
Rice blast
Trehalose-6-phosphate synthase
Isopropanolamine compounds
Inhibitor
Fungicidal mechanism
Selective PPAR gamma modulator diosmin improves insulin sensitivity and promotes browning of white fat
期刊论文
OAI收割
JOURNAL OF BIOLOGICAL CHEMISTRY, 2023, 卷号: 299, 期号: 4, 页码: 14
作者:
Yu, Jian
;
Hu, Yepeng
;
Sheng, Maozheng
;
Gao, Mingyuan
;
Guo, Wenxiu
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2023/10/17
Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as novel and potent TBK1 inhibitors: design, synthesis, biological evaluation, and molecular docking study
期刊论文
OAI收割
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 卷号: 37, 期号: 1, 页码: 1411-1425
作者:
Sun, Yin
;
Tang, Haotian
;
Wang, Xiaoyan
;
Feng, Fang
;
Fan, Tiantian
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2022/08/16
TBK1 inhibitors
1H-pyrazolo[3
4-b]pyridine
structure-activity relationships (SARs)
immune response
cancer therapy
Comprehensive Transcriptome Profiling of NAFLD- and NASH-Induced Skeletal Muscle Dysfunction
期刊论文
OAI收割
FRONTIERS IN ENDOCRINOLOGY, 2022, 卷号: 13, 页码: 14
作者:
Guo, Mingwei
;
Xiang, Liping
;
Yao, Jing
;
Zhang, Jun
;
Zhu, Shuangshuang
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2022/08/30
NAFLD
NASH
quadriceps muscle
lipid deposition
insulin resistance
myokines
Discovery of a series of 1H-pyrrolo[2,3-b]pyridine compounds as potent TNIK inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 33, 页码: 127749
作者:
Yang, Bowen
;
Wu, Qian
;
Huan, Xiajuan
;
Wang, Yingqing
;
Sun, Yin
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/03/21
TNIK inhibitor
1H-pyrrolo[2,3-b]pyridine
IL-2 secretion inhibitory
Divalent tranylcypromine derivative as lysine-specific demethylase 1 inhibitor
期刊论文
OAI收割
MEDICINAL CHEMISTRY RESEARCH, 2021, 页码: 8
作者:
Sun, Yin
;
Li, Na
;
Su, Mingbo
;
Wang, Xiaowen
;
Zhao, Dongmei
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/05/24
Divalent tranylcypromine
LSD1 inhibitor
MV4-11 antiproliferative activity
CD86 mRNA expression
Linker
Selectivity
Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure-activity relationship, crystal structural characterization and and in vivo study
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 2, 页码: 351-368
作者:
Wei, Peng
;
Liu, Bo
;
Wang, Ruifeng
;
Gao, Yinglei
;
Li, Lanlan
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/07/01
Fibroblast growth factor
Tyrosine kinase receptor
Structure-based
Crystallography
Selectivity
Hybrid
5-Hydrosulfonyl-5H- pyrrolo[2.3-b]pyrazine
Inhibitor
Stereoselective N-glycosylation with N-4-acyl cytosines and efficient synthesis of gemcitabine
期刊论文
OAI收割
TETRAHEDRON, 2019, 卷号: 75, 期号: 9, 页码: 1203-1213
作者:
Liu, Tongchao
;
Tang, Jiadeng
;
Liang, Jianpeng
;
Chen, Yabin
;
Wang, Xiaowen
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2020/07/01
Stereoselective
N-glycosylation
N-4-acyl cytosine
Nucleoside
Gemcitabine
Discovery and Biological Evaluation of a Series of Pyrrolo[2,3-b]pyrazines as Novel FGFR Inhibitors
期刊论文
OAI收割
MOLECULES, 2017, 卷号: 22, 期号: 4
作者:
Zhang, Yan
;
Liu, Hongchun
;
Zhang, Zhen
;
Wang, Ruifeng
;
Liu, Tongchao
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
FGFR1
inhibitor
kinase inhibitor
pyrazine
hinge binder
bufalinderivativebf211inhibitsproteasomeactivityinhumanlungcancercellsinvitrobyinhibiting1subunitexpressionanddisruptingproteasomeassembly
期刊论文
OAI收割
actapharmacologicasinica, 2016, 卷号: 000, 期号: 007, 页码: 908
作者:
Pengsun
;
Feng Lixing
;
Zhang Dongmei
;
Liu Miao
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/07/01
26S蛋白酶体
肺癌细胞
活性肽
衍生物
亚基
体外抑制
蟾酥
A549细胞