中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [13]
采集方式
OAI收割 [13]
内容类型
期刊论文 [13]
发表日期
2024 [2]
2023 [1]
2022 [5]
2016 [2]
2015 [1]
2013 [1]
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专题:上海药物研究所
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Rational design and discovery of novel oxalate-like derivatives as aphid-repellent candidates based on odorant-binding protein 3
期刊论文
OAI收割
JOURNAL OF MOLECULAR STRUCTURE, 2024, 卷号: 1301, 页码: 11
作者:
Zhu, Ziwei
;
Li, Jianing
;
Liu, Chong
;
Li, Huilin
;
Lu, Xingxing
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/04/09
Odorant-binding protein
Oxalate-like derivatives
Rational design
Repellent activity
Behavioural control agents
Development and validation of a sensitive liquid chromatography-tandem mass spectrometry method for the assay of 12 substances in rat plasma and its application to rat pharmacokinetics of
Epimedium
and
Psoraleae Fructus
herb pair after oral administration
期刊论文
OAI收割
JOURNAL OF SEPARATION SCIENCE, 2024, 卷号: 47, 期号: 1, 页码: 17
作者:
Wang, Linwei
;
Yin, Xiaoying
;
Liu, Huan
;
Wang, Yangyang
;
Li, Zhixiong
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/02/27
compatibility behaviors
Epimedium
LC-MS/MS
pharmacokinetics
Psoraleae Fructus
Discovery of 7H-Pyrrolo[2,3-d]pyrimidine Derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 254, 页码: 15
作者:
Wu, Feifei
;
Li, Huiyu
;
An, Qi
;
Sun, Yaoliang
;
Yu, Jinghua
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2023/10/17
Hematopoietic progenitor kinase 1 (HPK1)
Cancer immunotherapy
Inhibitor
T cell
A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1 beta and IL-6
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2022, 卷号: 12, 期号: 11, 页码: 4180-4192
作者:
Liao, Liping
;
Dang, Wenzhen
;
Lin, Tingting
;
Yu, Jinghua
;
Liu, Tonghai
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2023/04/10
Glycolysis
Phosphoglycerate kinase 1
Macrophages
NRF2
Inflammation
A Traceless Site-Specific Conjugation on Native Antibodies Enables Efficient One-Step Payload Assembly
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 页码: 11
作者:
Zeng, Yue
;
Shi, Wei
;
Dong, Qian
;
Li, Wanzhen
;
Zhang, Jianxin
  |  
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2022/08/30
Acyl Transfer
Anti-Tumor
One-Step Synthesis
Site-Specific ADCs
Thioester
Mechanistic Study on the Species Differences in Excretion Pathway of HR011303 in Humans and Rats
期刊论文
OAI收割
DRUG METABOLISM AND DISPOSITION, 2022, 卷号: 50, 期号: 6, 页码: 809-818
作者:
Guo, Zitao
;
Liu, Mengling
;
Meng, Jian
;
Xue, Yaru
;
Huang, Qi
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/08/16
Pharmacokinetics, Mass Balance, and Metabolism of the Novel Urate Transporter 1 Inhibitor [14C]HR011303 in Humans: Metabolism Is Mediated Predominantly by UDP-Glucuronosyltransferase
期刊论文
OAI收割
DRUG METABOLISM AND DISPOSITION, 2022, 卷号: 50, 期号: 6, 页码: 798-808
作者:
Zheng, Yuandong
;
Zhang, Hua
;
Liu, Mengling
;
Li, Guangze
;
Ma, Sheng
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/08/16
Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 5, 页码: 3923-3942
作者:
Zhou, Chuan
;
Fan, Zisheng
;
Zhou, Zehui
;
Li, Yupeng
;
Cui, Rongrong
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2022/06/15
Metabolic characterization of pyrotinib in humans by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry
期刊论文
OAI收割
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2016, 卷号: 1033, 页码: 117-127
作者:
Zhu, Yunting
;
Li, Liang
;
Zhang, Ge
;
Wan, Hong
;
Yang, Changyong
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Pyrotinib
UPLC/Q-TOF MS
Metabolism
Human
CYP3A4
Drug-drug interaction
Effect of N-methyl deuteration on metabolism and pharmacokinetics of enzalutamide
期刊论文
OAI收割
DRUG DESIGN DEVELOPMENT AND THERAPY, 2016, 卷号: 10, 页码: 2181-2191
作者:
Jiang, Jinfang
;
Pang, Xuehai
;
Li, Liang
;
Dai, Xiaojian
;
Diao, Xingxing
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
enzalutamide
N-methyl deuteration
deuterium kinetic isotope effect
pharmacokinetics