中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [45]
采集方式
OAI收割 [45]
内容类型
期刊论文 [45]
发表日期
2024 [1]
2023 [4]
2022 [14]
2021 [4]
2020 [3]
2019 [7]
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专题:上海药物研究所
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Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses
期刊论文
OAI收割
NATURE CHEMICAL BIOLOGY, 2024, 页码: 29
作者:
Zhou, Xiaoyu
;
Zhao, Cheng
;
Xu, Haiyan
;
Xu, Yixiang
;
Zhan, Li
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/03/25
Diterpenoids from Euphorbia lactea and their anti-HIV-1 activity
期刊论文
OAI收割
PHYTOCHEMISTRY, 2023, 卷号: 213, 页码: 11
作者:
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/10/17
Euphorbia lactea Haw
Euphorbiaceae
Diterpenoid
Ingol
Ent -pimarane
Anti-HIV-1
The PIWI-specific insertion module helps load longer piRNAs for translational activation essential for male fertility
期刊论文
OAI收割
SCIENCE CHINA-LIFE SCIENCES, 2023, 页码: 23
作者:
Wang, Xin
;
Lin, Di-Hang
;
Yan, Yue
;
Wang, An-Hui
;
Liao, Jiaoyang
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/10/17
PIWI
piRNAs
PIWI-Ins
translational activation
spermatid development
male fertility
Suadimins D-J, Monoterpenoid Indole-Quinoline and Bisindole Alkaloids from Melodinus suaveolens
期刊论文
OAI收割
CHINESE JOURNAL OF CHEMISTRY, 2023, 页码: 2296-2304
作者:
Gao, Xin-Hua
;
Wu, Pei-Qian
;
Fan, Yao-Yue
;
Zhou, Bin
;
Yue, Jian-Min
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2023/10/17
Melodinus suaveolens
Alkaloids
Dimerization
Structure elucidation
ECD calculations
Cytotoxic activity
Conjugation site characterization of antibody-drug conjugates using electron-transfer/higher-energy collision dissociation (EThcD)
期刊论文
OAI收割
ANALYTICA CHIMICA ACTA, 2023, 卷号: 1251, 页码: 7
作者:
Song, Yuanli
;
Gao, Jing
;
Meng, Qian
;
Tang, Feng
;
Wang, Yuqiu
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/10/17
Antibody -drug conjugates
EThcD
Conjugation site
Peptide mapping
Quality control
Design, synthesis and in vitro biological evaluation of marine phidianidine derivatives as potential anti-inflammatory agents
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2022, 卷号: 71, 页码: 116936
作者:
Xu, Quan
;
Zhao, Ning
;
Liu, Jin
;
Song, Jin-Qian
;
Huang, Li-Hua
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/03/21
Indole alkaloids
Marine natural products
Phidianidines
Anti-inflammatory activities
Molecular docking
Multi-omics analysis reveals the pathogenesis of db/db mice diabetic kidney disease and the treatment mechanisms of multi-bioactive compounds combination from Salvia miltiorrhiza
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13, 页码: 16
作者:
Xu, Zhuo
;
Xiang, Xiang
;
Su, Shulan
;
Zhu, Yue
;
Yan, Hui
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2022/12/13
multi-bioactive compounds combination
diabetic kidney disease
multi-omics
Salvia miltiorrhiza
PI3K/Akt/FoxO signaling pathways
Loss of SIRT5 promotes bile acid-induced immunosuppressive microenvironment and hepatocarcinogenesis
期刊论文
OAI收割
JOURNAL OF HEPATOLOGY, 2022, 卷号: 77, 期号: 2, 页码: 453-466
作者:
Sun, Renqiang
;
Zhang, Zhiyong
;
Bao, Ruoxuan
;
Guo, Xiaozhen
;
Gu, Yuan
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/03/21
SIRT5
bile acid
macrophage polarization
immunosuppressive tumor microenvironment
liver cancer
SCN8A epileptic encephalopathy mutations display a gain-of-function phenotype and divergent sensitivity to antiepileptic drugs
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 10
作者:
Guo, Qian-bei
;
Zhan, Li
;
Xu, Hai-yan
;
Gao, Zhao-bing
;
Zheng, Yue-ming
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2022/08/30
early infantile epileptic encephalopathy type 13
SCN8A
gain-of-function mutation
antiepileptic drugs
phenytoin
carbamazepine
A Traceless Site-Specific Conjugation on Native Antibodies Enables Efficient One-Step Payload Assembly
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 页码: 11
作者:
Zeng, Yue
;
Shi, Wei
;
Dong, Qian
;
Li, Wanzhen
;
Zhang, Jianxin
  |  
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2022/08/30
Acyl Transfer
Anti-Tumor
One-Step Synthesis
Site-Specific ADCs
Thioester