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化学研究所 [24]
上海药物研究所 [9]
武汉物理与数学研究所 [3]
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期刊论文 [46]
会议论文 [1]
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Chemistry [1]
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Reversal of subtype-selectivity and function by the introduction of a para-benzamidyl substituent to N-cyclopropylmethyl nornepenthone
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 258, 页码: 15
作者:
Kong, Linghui
;
Ning, Kuan
;
Liu, Xiao
;
Lu, Jiashuo
;
Chen, Baiyu
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/10/17
N-cyclopropylmethyl nornepenthone derivatives
derivatives
Structure-activity relationship
MOR antagonist
Functional reversal
Reversal of subtype-selectivity
Opioid use disorder
PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 1, 页码: 157-173
作者:
Sun, Mingming
;
Li, Leilei
;
Niu, Yujia
;
Wang, Yingzhi
;
Yan, Qi
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/03/27
Lung cancer
Metabolic reprogramming
Post-translational modification
PRMT6
Pentose phosphate pathway flux
Glycolysis
6-Phospho-gluconate dehydrogenase
a-enolase
ENO1
SLL-627 Is a Highly Selective and Potent ? Opioid Receptor (KOR) Agonist with an Unexpected Nonreduction in Locomotor Activity
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 16
作者:
Kong, Linghui
;
Shu, Xuelian
;
Tang, Siyuan
;
Ye, Rongrong
;
Sun, Huijiao
  |  
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2022/08/30
Coupled Simulation of Hydrate-Bearing and Overburden Sedimentary Layers to Study Hydrate Dissociation and Methane Leakage
期刊论文
OAI收割
JOURNAL OF MARINE SCIENCE AND ENGINEERING, 2022, 卷号: 10, 期号: 5, 页码: 19
作者:
Xie, Yan
;
Feng, Jingchun
;
Sun, Liwei
;
Wang, Junwen
;
Hu, Weiqiang
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/11/21
natural gas hydrate
methane leakage
CH4 hydrate dissociation
simulator
dynamic separation
Deep-Sea Sediment and Water Simulator for Investigation of Methane Seeping and Hydrate Formation
期刊论文
OAI收割
JOURNAL OF MARINE SCIENCE AND ENGINEERING, 2022, 卷号: 10, 期号: 4, 页码: 17
作者:
Xie, Yan
;
Feng, Jingchun
;
Hu, Weiqiang
;
Zhang, Mingrui
;
Wang, Junwen
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2023/11/21
methane seeping
hydrate formation
cold seep
simulator
Two hydrothermal events associated with Au mineralization in the Youjiang Basin, southwestern China
期刊论文
OAI收割
Ore Geology Reviews, 2022, 卷号: 144, 页码: 104816
作者:
Lujing Zheng
;
Qinping Tan
;
Yujun Zuo
;
Yong Xia
;
Zhuojun Xie
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2023/05/04
Mineralization
carlin-type Au Deposit
lannigou
youjiang Basin
The methyltransferase METTL3 negatively regulates nonalcoholic steatohepatitis (NASH) progression
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2021, 卷号: 12, 期号: 1, 页码: 17
作者:
  |  
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2022/01/18
Parallel attention-based LSTM for building a prediction model of vehicle emissions using PEMS and OBD
期刊论文
OAI收割
MEASUREMENT, 2021, 卷号: 185
作者:
Xie, Hao
;
Zhang, Yujun
;
He, Ying
;
You, Kun
;
Fan, Boqiang
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2021/11/29
PEMS
Time series prediction
Deep learning
Early warning of high emissions
Outliers elimination
Discovery of an M-Substituted N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active kappa-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12414-12433
作者:
He, Qian
;
Wei, Yuanyuan
  |  
收藏
  |  
浏览/下载:83/0
  |  
提交时间:2021/11/04
Discovery, Structure-Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 13, 页码: 9458-9483
作者:
Huang, Huoming
;
Li, Xueping
;
Xie, Peng
;
Li, Xinwei
;
Xu, XueJun
  |  
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2021/08/17